Oral cancer is a heterogeneous and aggressive disease with poor survival rates. Current treatments include surgery and radiotherapy, and few targeted treatments exist today. Treatment-related side effects are often serious and life-long, including dry mouth, speech impairment, challenges with eating and drinking, changes in the taste and smell sensation, dental problems as well as disfiguring defects after surgery. There is a clear need for better treatment options that improve survival and reduce the treatment-related side effects.