About
HubMOL is a Marie Skłodowska-Curie Actions Doctoral Network funded by Horizon Europe.
The hub molecules of life comprise a set of cofactors that are crucial for all cellular functions. They are well known for their central roles in both metabolism and signalling. Still, our limited knowledge of the crosstalk and the reciprocal connectivity between key metabolic and signal transduction pathways and the dynamic interplay of hub molecules is currently hampering their exploitation. Imbalances in hub molecule levels have been associated with a wide range of disease states such as diabetes, obesity, cancer, and neurodegenerative syndromes. Since maintenance of hub molecules requires the intake of essential nutritional precursors, promising opportunities for therapies, including targeted nutritional supplementation, are envisaged. To address the demand for competence in this topical area, HubMOL will train the next generation of specialists in the latest enabling technologies in metabolomics, protein modification analysis and molecular organismal physiology to develop novel hub molecule supplementation strategies and pharmacological approaches targeting hub molecule-dependent signalling and gene regulation. Our systems medicine approach will include latest computational modelling approaches thereby further boosting the employability of HubMOL trained researchers as future leaders in clinical nutritional intervention strategies, new biotechnological approaches for and in pharmacological translation, namely, from drug target identification to clinical validation.
