Tromsø Endocrine Research Group focuses on a variety of endocrinologic research questions. A main focus area is steroid hormones, historically through a combined approach of epidemiological, laboratory and RCT studies on effects of vitamin D. In recent years the focus has been expanded to include adrenal hormones and sex hormones with a goal of building up a platform for studies on reproductive health, based on data collections like Fit Futures. We have a strong laboratory platform when it comes to both mass spectrometric methods for hormone measurements as well as endocrine disruptive chemicals (EDCs) through the collaboration with The Environmental Pollutant Laboratory at the Department of Laboratory Medicine, UNN Tromsø, which facilitates studies on effects of EDCs on endocrine health.
Oyeyemi SO, Averina M, Huber S, Charles D, Furberg AS, Yigzaw KY, Wilsgaard T, Nielsen CS, Grimnes G. Per- and polyfluoroalkyl substances and associated proteomic biomarker patterns of immuno-suppression and cell-proliferation in an adolescent population from Northern Norway: The Fit Futures Study. Environ Res. 2025:122096. doi: 10.1016/j.envres.2025.122096. Epub ahead of print. PMID: 40482803.
Jorde R. Vitamin D kan forebygge diabetes. Tidsskr Nor Laegeforen. 2025 Apr 4;145(5). doi: 10.4045/tidsskr.25.0119. Print 2025 Apr 22.PMID: 40272138
Joakimsen HL, Brendlien A, Furberg AS, Nielsen CS, Grimnes G, Evensen EK Age at menarche and its association with preschool BMI among girls in Northern Norway. PLoS One. 2025 May 13;20(5):e0322986. doi: 10.1371/journal.pone.0322986. eCollection 2025.PMID: 40359425
Andreasen C, Dahl C, Frihagen F, Borgen TT, Basso T, Gjertsen JE, Figved W, Wisløff T, Hagen G, Apalset EM, Stutzer JM, Lund I, Hansen AK, Nissen FI, Joakimsen RM, Syversen U, Eriksen EF, Nordsletten L, Omsland TK, Bjørnerem Å, Solberg LB. Fracture liaison service (FLS) is associated with lower subsequent fragility fracture risk and mortality: NoFRACT (the Norwegian capture the fracture initiative). Osteoporos Int. 2025 Mar;36(3):501-512. doi:10.1007/s00198-024-07376-y. Epub 2025 Jan 14. PMID: 39808195; PMCID: PMC11882684.
Fosse, G.Ø., Huber, S., Brox, J., Grimnes, G., Averina, M. (2025, May 11-15). Per- and Polyfluoroalkyl Substance (PFAS) Exposure, Cardiovascular Disease Risk, and Cardiometabolic Health Effects in the Arctic Population of Norway. The Tromsø Study [Poster presentation]. SETAC Europe 35th Annual Meeting, Vienna, Austria.
Jenssen M, Arora N, Løset M, Åsvold BO, Thomas L, Bekkevold Vassmyr O-J, Mai X-M, Yi-Qian Sun, Sofie Furberg A-S, Jorde R, Wilsgaard T, Danielsen K, Brumpton BM. Exploring Interaction between Genetically Predicted Body Mass Index and Serum 25-Hydroxyvitamin D Levels on the Odds for Psoriasis in UK Biobank and the HUNT Study: A Factorial Mendelian Randomization Study. JID Innovations 2025;5:100336 doi:10.1016/j.xjidi.2024.100336
Wang Q, Akdeniz C, Heck A, Bjørk MB, Theisen OR, Eggesbø HB, Krüger TB, Reseland JE, Pihlstrøm HK, Åsvold BO, Grimnes G, Grytaas MA, Rafaelsen SH, Thorsby PM, Wekre LL, Finnes TE. X-linked hypophosphataemia. Tidsskr Nor Laegeforen. 2025 Feb 26;145(3). doi: 10.4045/tidsskr.24.0476. Print 2025 Mar 4.PMID: 40042024
Sagelv EH, Emaus N, Evensen E, Christoffersen T, Dennison E, Furberg AS, Grimnes G, Johansson J, Nielsen CS, Nilsen OA, Winther A.Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010-2022. Arch Osteoporos. 2024 Jul 3;19(1):58. doi: 10.1007/s11657-024-01414-2.PMID: 38960953
Holvik K, Dahl C, Samuelsen SO, Søgaard AJ, Solbakken SM, Tell GS, Hoff M, Schei B, Kjeldgaard HK, Apalset EM, Morseth B, Grimnes G, Meyer HE, Omsland TK.Educational gradient in hip fracture incidence in Norway. The Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). Osteoporos Int. 2024 Nov;35(11):2047-2053. doi: 10.1007/s00198-024-07133-1. Epub 2024 Jun 25.PMID: 38918222
Averina M, Huber S, Almås B, Brox J, Jacobsen BK, Furberg AS, Grimnes G. Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study. Environ Red 2024: 10.1016/j.envres.2023.117703
Allaoui G, Rylander C, Fuskevåg OM, Grimnes G, Averina M, Wilsgaard T, Berg V. Longitudinal assessment of classic and 11-oxygenated androgen concentrations and their association with type 2 diabetes mellitus development: the Tromsø study. Acta Diabetol. 2024 Jul;61(7):847-857.
Öberg J, Jorde R, Almås B, Nielsen CS, Gerds TA, Cashman KD, Grimnes G. Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years' Follow-up From the Fit Futures Study. J Clin Endocrinol Metab. 2024 Feb 20;109(3):e1029-e1039. doi: 10.1210/clinem/dgad655. PMID: 37955862; PMCID: PMC10876399.
Jenssen M, Furberg AS, Jorde R, Wilsgaard T, Danielsen K. The association between serum 25-hydroxyvitamin D levels and psoriasis in a large population-based cohort, a cross-sectional analysis of The Tromsø Study 2015-16. Br J Dermatol 2024 Apr 17;190(5):680-688. doi:10.1093/bjd/ljad472
Charles D, Berg V, Nøst TH, Wilsgaard T, Bergdahl IA, Huber S, Ayotte P, Averina M, Sandanger T, Rylander C. Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis. Int J Hyg Environ Health. 2023 Apr;249:114148. doi: 10.1016/j.ijheh.2023.114148. Epub 2023 Mar 5.PMID: 36881976
Allaoui G, Rylander C, Fuskevåg OM, Averina M, Wilsgaard T, Brustad M, Jorde R, Berg V. Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study. Acta Diabetol. 2023 Feb;60(2):293-304.
Kiessling C, Perron NJ, van Nuland M, Bujnowska-Fedak MM, Essers G, Joakimsen RM, Pype P, Tsimtsiou Z. Does it make sense to use written instruments to assess communication skills? Systematic review on the concurrent and predictive value of written assessment for performance. Patient Educ Couns. 2023 Mar;108:107612.doi: 10.1016/j.pec.2022.107612. Epub 2022 Dec 23. PMID: 36603470.
Pittas AG, Kawahara T, Jorde R, Dawson-Hughes B, Vickery EM, Angellotti E, Nelson J, Trikalinos TA, Balk EM. Vitamin D and Risk for Type 2 Diabetes in People with Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials. Ann Intern Med. 2023 Mar;176(3):355-363. doi: 10.7326/M22-3018. Epub 2023 Feb 7. PMID: 36745886
Pittas AG, Kawahara T, Jorde R, Dawson-Hughes B, Balk EM. Vitamin D and Risk for Type 2 Diabetes in People with Prediabetes. Ann Intern Med. 2023 Aug;176(8): eL230202. doi: 10.7326/L23-0202.PMID: 37579334
Jenssen M, Furberg AS, Jorde R, Wilsgaard T, Danielsen K. Effect of Vitamin D Supplementation on Psoriasis Severity in Patients with Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial. JAMA Dermatol. 2023 May 1;159(5):518-525. doi: 10.1001/jamadermatol.2023.0357.PMID: 36988936
Omsland TK, Solberg LB, Bjørnerem Å, Borgen TT, Andreasen C, Wisløff T, Hagen G, Basso T, Gjertsen JE, Apalset EM, Figved W, Stutzer JM, Nissen FI, Hansen AK, Joakimsen RM, Figari E, Peel G, Rashid AA, Khoshkhabari J, Eriksen EF, Nordsletten L, Frihagen F, Dahl C. Validation of forearm fracture diagnoses in administrative patient registers. Arch Osteoporos. 2023 Aug 24;18(1):111. doi:10.1007/s11657-023-01322-x. PMID: 37615791; PMCID: PMC10449697.
Sævik ÅB, Ueland G, Åkerman AK, Methlie P, Quinkler M, Jørgensen AP, Höybye C, Debowska AWJ, Nedrebø BG, Dahle AL, Carlsen S, Tomkowicz A, Sollid ST, Nermoen I, Grønning K, Dahlqvist P, Grimnes G, Skov J, Finnes T, Valland SF, Wahlberg J, Holte SE, Kämpe O, Bensing S, Husebye ES, Øksnes M. Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study. Eur J Endocrinol 2023: doi: 10.1093/ejendo/lvad136
Åkerman AK, Sævik ÅB, Thorsby PM, Methlie P, Quinkler M, Jørgensen AP, Höybye C, Debowska AJ, Nedrebø BG, Dahle AL, Carlsen S, Tomkowicz A, Sollid ST, Nermoen I, Grønning K, Dahlqvist P, Grimnes G, Skov J, Finnes T, Wahlberg J, Holte SE, Simunkova K, Kämpe O, Husebye ES, Øksnes M, Bensing S. Plasma-Metanephrines in Patients with Autoimmune Addison's Disease with and without Residual Adrenocortical Function. J Clin Med 2023: doi: 10.3390/jcm12103602
Holvik K, Ellingsen CL, Solbakken SM, Finnes TE, Talsnes O, Grimnes G, Tell GS, Søgaard AJ, Meyer HE. Cause-specific excess mortality after hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). BMC Geriatr. 2023 Mar 31;23(1):201. doi: 10.1186/s12877-023-03910-5
Allaoui G, Rylander C, Averina M, Wilsgaard T, Fuskevåg OM, Berg V. Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus-The Tromsø study. Endocrinol Diabetes Metab. 2022 Mar;5(2).
Öberg J, Jorde R, Figenschau Y, Thorsby PM, Dahl SR, Winther A, Grimnes G. 100 YEARS OF VITAMIN D: Combined hormonal contraceptives and vitamin D metabolism in adolescent girls. Endocr Connect. 2022 Mar 31;11(3):e210395. doi: 10.1530/EC-21-0395. PMID: 35213326; PMCID: PMC9002185.
Perron NJ, Pype P, van Nuland M, Bujnowska-Fedak MM, Dohms M, Essers G, Joakimsen R, Tsimtsiou Z, Kiessling C. What do we know about written assessment of health professionals' communication skills? A scoping review. Patient Educ Couns. 2022 May;105(5):1188-1200. doi: 10.1016/j.pec.2021.09.011. Epub 2021 Sep15. PMID: 34602334.
Larsen AU, Hopstock LA, Jorde R, Grimnes G. Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study. Sleep Med X. 2022 Sep 6;4: 100056. doi: 10.1016/j.sleepx.2022.100056. eCollection 2022 Dec.
Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Ericson JU, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general male population. Epidemiol Infect 2022:doi: 10.1017/S0950268822000735.
Lund CI, Engdahl B, Rosseland LA, Stubhaug A, Grimnes G, Furberg AS, Steingrímsdóttir ÓA, Nielsen CS. The association between age at menarche and chronic pain outcomes in women: the Tromsø Study, 2007 to 2016. Pain, 2022: doi: 10.1097/j.pain.0000000000002579.
Linkas J, Ahmed LA, Csifcsak G, Emaus N, Furberg AS, Grimnes G, Pettersen G, Rognmo K, Christoffersen T. C-reactive protein and TGF-alfa predict psychological distress at two years of follow-up in healthy adolescent boys: The Fit Futures Study. Front Psychol, 2022 doi: 10.3389/fpsyg.2022.823420.
Linkas J, Ahmed LA, Csifcsak G, Emaus N, Furberg AS, Grimnes G, Pettersen G, Rognmo K, Christoffersen T. Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15-17 years of age? The Fit Futures study. BMC Psychol, 2022;10(1):65.
Berg V, Charles D, Bergdahl IA, Nøst TH, Sandanger TM, Tornevi A, Huber S, Fuskevåg OM, Rylander C. Pre- and post-diagnostic blood profiles of chlorinated persistent organic pollutants and metabolic markers in type 2 diabetes mellitus cases and controls; a pilot study. Environ Res. 2021 Apr;195:110846
Averina M, Brox J, Huber S, Furberg AS Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents. The Fit Futures study. Environ Res. 2021 Apr;195:110740. doi: 10.1016/j.envres.2021.110740. Epub 2021 Jan 15.PMID: 33460636
Nordvåg SK, Solbu MD, Melsom T, Nissen FI, Andreasen C, Borgen TT, Eriksen BO, Joakimsen RM, Bjørnerem Å. Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study. Bone. 2021 Jul;148:115960. doi: 10.1016/j.bone.2021.115960. Epub 2021 Apr14. PMID: 33864977.
Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Response to Letter to the Editor from Dalan: "Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?". J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1928-e1929. doi: 10.1210/clinem/dgaa971.PMID: 33377909
Ruiz PL, Hopstock LA, Eggen AE, Njølstad I, Grimnes G, Stene LC, Gulseth HL. Undiagnosed diabetes base don HbA1c by sosioeconomic status and healthcare consumption in the Tromsø Study 1994-2016. BMJ Open Diabetes Res Care, 2021 doi: 10.1136/bmjdrc-2021-002423.
Larsen AU, Hopstock LA, Jorde R, Grimnes G. No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial. Sleep Med X. 2021 Oct 19;3:100040. doi: 10.1016/j.sleepx.2021.100040. eCollection 2021 Dec.PMID: 34881361
Langholz PL, Wilsgaard T, Njølstad I, Jorde R, Hopstock LA. Trends in known and undiagnosed diabetes, HbA1c levels, cardiometabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys: the population-based Tromsø Study 1994-2016. BMJ Open. 2021 Mar 23;11(3):e041846. doi: 10.1136/bmjopen-2020-041846.PMID: 33757943
Nilsen OA, Emaus N, Christoffersen T, Winther A, Evenesen E, Thrane G, Furberg AS, Grimnes G, Ahmed LA. The influence of snuff and smoking on bone accretion in late adolescence. The Tromsø Study, Fit Futures. Arch Osteoporos, 2021: doi: 10.1007/s11657-021-01003-7
Kubiak J, Kamycheva E, Jorde R. Tracking of serum 25-hydroxyvitamin D during 21 years. Eur J Clin Nutr. 2021 Jul;75(7):1069-1076. doi: 10.1038/s41430-020-00814-0. Epub 2020 Dec 11.PMID: 33311556
Stensen DB, Småbrekke L, Olsen K, Grimnes G, Nielsen CS, Sollid JUE, Simonsen GS, Almås B, Furberg AS. Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol 2021;184:337-346.
Jorde R, Grimnes G. Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study. BMC Nutr. 2020 Nov 2;6(1):49. doi: 10.1186/s40795-020-00381-4.PMID: 33292616
Fleet JC, Bernal-Mizrachi C, Hewison M, Jorde R, White J, Cantorna M, Schoenmakers I, Erben R. Highlights from the 22nd workshop on vitamin D in New York City, May 2019. J Steroid Biochem Mol Biol. 2020 Oct;203:105747. doi: 10.1016/j.jsbmb.2020.105747.
Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? J Clin Endocrinol Metab. 2020 Dec 1;105(12):3721-33. doi:10.1210/clinem/dgaa594.PMID: 32844212
Bjorke-Monsen AL, Varsi K, Averina M, Brox J, Huber S.Perfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: association with fish consumption and unfavorable lipid profile. BMJ Nutr Prev Health 2020 Nov 4;3(2):277-284. doi: 10.1136/bmjnph-2020-000131. eCollection 2020 Dec.PMID: 33521539
Averina M, Hervig T, Huber S, Kjaer M, Kristoffersen EK, Bolann B. Environmental pollutants in blood donors: The multicentre Norwegian donor study. Transfus Med 2020 Jun;30(3):201-209. doi: 10.1111/tme.12662. Epub 2020 Jan 11.PMID: 31926037 Clinical Trial.
Estrogen replacement therapy (ERT) for treatment of adolescent anorexia nervosa – A randomized controlled pilot study.
P.I. Per Aslaksen, IPS, UiT
Grant from HN
Collaborators: Guri Grimnes, Yngve Figenschau, Ole-Martin Fuskevåg
FENDURA – ernæring, beinhelse, hormoner, og prestasjon hos kvinnelige idrettsutøvere
P.I. Boye Welde, Idrettshøgskolen, UiT
Grant from TFS
Collaborators: Ole-Martin Fuskevåg, Guri Grimnes
Dynamic hormone diagnostic in adrenal disease
P.I. Eystein Husebye, Helse Vest
Grant from NFR
Collaborators: Guri Grimnes
RCT – type of cortisone substitution in Addison disease
P.I. Eystein Husebye, Helse Vest
Grant from NFR
Steroid hormone levels and diabetes in the Tromsø Study
P.I. Vivian Berg, IMB, UiT
Grant from HN
Collaborators: Ole-Martin Fuskevåg, Rolf Jorde, Guri Grimnes
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