The significance of novel adrenal androgens for polycystic ovary syndrome (PCOS) traits, metabolic regulation, and bone mineral density in young adults
In this project, we aim to investigate the 11-OxyA in healthy young adults from the third Fit Futures Study, in order to broaden the knowledge surrounding these 11-OxyA.
The 11-oxygenated androgens (11-OxyA) are a novel group of C19 steroids originating from the adrenal gland. These androgens are synthesized through the 11-oxygenated pathway from testosterone and androstenedione, the end-products of the classical pathway. Evidence suggests that the adrenal gland only secretes 11β-hydroxyandrostenedione (11OHA4), and subsequent conversions occur in peripheral tissues.
Notably, 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT) are endocrinologically active androgens with similar affinity to the androgen receptor as testosterone and dihydrotestosterone. The 11-OxyA have been found to vary across age, sex, BMI, fat mass, and pregnancy. Additionally, 11-OxyA are elevated in hyperandrogenic conditions such as polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia (CAH).
We will explore the associations of 11-OxyA with body composition, metabolic markers, contraception use, and hyperandrogen features in a population-based cohort of young men and women.
Members:
Financial/grant information:
Grant form Institute of Clinical Medicine, UiT