ASTI is a capacity-building project to establish UiT as a centre of excellence for research into seasonal timekeeping mechanisms. This fills a strategic gap in chronobiology research worldwide, and is an excellent fit to UiT as the world’s northernmost research university.
ASTI will combine excellence in genome-enabled approaches to define the genetic basis of seasonal timer mechanisms (transcriptomics, comparative genomics, epigenomics, gene targeting), with state of the art approaches to in-vivo analysis of seasonal changes in physiology and behaviour (microdialysis, metabolomics, endocrinology, telemetry), and integration of complementary approaches through data processing capacity (mathematical network modelling, database management and data sharing).
ASTI will cover three overlapping themes spanning both basic and applied / societally important aspects: ‘Core seasonal timer mechanisms’, ‘Comparative seasonal chronobiology’ and ‘One seasonal health’.
ASTI will enhance awareness and understanding of the importance of seasonal timekeeping mechanisms for the health and wellbeing of humans and animals living in the Arctic region.
The centre project period is 1st April 2021 to 31st March 2025. The centre director is Professor David Hazlerigg and deputy director is Dr. Shona Wood. The centre is based within the research group Arctic chronobiology and physiology at the Department of Arctic and Marine biology.
ASTI LAUNCH 1st April 2021
Winter/Spring 2021 seminar program
Fredrik Markussen, Arctic chronobiology and physiology, UiT
New PhD project description: Torpor-arousal cycling during hibernation
Shona Wood, Arctic chronobiology and physiology, UiT
Laura van Rosmalen, Institute for evolutionary life science, University of Groningen
Guest speaker: Seasonal modifiers of reproduction and ultradian behaviour in voles
Jayme Van Dalum, Arctic chronobiology and physiology, UiT
Paper in preparation: Photoperiodic responses in voles
List of key publications from 2020 onwards:
Neuroendocrine Clocks and Calendars, Editors: Ebling, Francis J. P., Piggins, Hugh D. (Eds.)
- An up-to-date and authoritative textbook explaining the mechanisms by which biological rhythms affect physiology and behaviour major contributions from key members of ASTI: Shona Wood, David Hazlerigg and Alex West
Markussen, F.A., Melum, V.J., Bothorel, B. et al. A refined method to monitor arousal from hibernation in the European hamster. BMC Vet Res 17, 14 (2021). https://doi.org/10.1186/s12917-020-02723-7
Striberny, A., (...) Hazlerigg, D.G., Jørgensen, E.H., Author links open overlay panelStriberny, A., … Hazlerigg, D.G, Jørgensen, E.H.Striberny, A., … Hazlerigg, D.G, Jørgensen, E.More than one way to smoltify a salmon? Effects of dietary and light treatment on smolt development and seawater growth performance in Atlantic salmon. Aquaculture 532, 15 (2021), 736044 (2021). https://doi.org/10.1016/j.aquaculture.2020.736044
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Laura van Rosmalen, Jayme van Dalum, David G. Hazlerigg, Roelof A. Hut
bioRxiv 2020.06.12.147777; doi: https://doi.org/10.1101/2020.06.12.147777
Alexander C. West, Yasutaka Mizoro, Shona H. Wood, Louise M. Ince, Marianne Iversen, Even H. Jørgensen, Torfinn Nome, Simen Rød Sandve, Andrew S. I. Loudon, David G. Hazlerigg
bioRxiv 2020.09.03.281337; doi: https://doi.org/10.1101/2020.09.03.281337
Daniel Appenroth, Gabriela C. Wagner, David G. Hazlerigg, Alexander C. West
bioRxiv 2020.08.17.254011; doi: https://doi.org/10.1101/2020.08.17.254011
Fredrik A. S. Markussen, Vebjørn J. Melum, Béatrice Bothorel, David G. Hazlerigg, Valérie Simonneaux, Shona H. Wood
bioRxiv 2020.04.20.009712; doi: https://doi.org/10.1101/2020.04.20.009712
Alexander C. West, Marianne Iversen, Even H. Jørgensen, Simen R. Sandve, David G. Hazlerigg, Shona H. Wood
bioRxiv 2020.03.22.002162; doi: https://doi.org/10.1101/2020.03.22.002162
Daniel Appenroth, Vebjørn J. Melum, Alexander C. West, Hugues Dardente, David G. Hazlerigg, Gabriela C. Wagner
bioRxiv 2020.06.19.160721; doi: https://doi.org/10.1101/2020.06.19.160721
Marianne Iversen, Teshome Mulugeta, Alexander West, Even Jørgensen, Samuel A. M. Martin, Simen Rød Sandve, David Hazlerigg
bioRxiv 2020.03.24.006510; doi: https://doi.org/10.1101/2020.03.24.006510
Elsa Denker, Lars O. E. Ebbesson, David G. Hazlerigg, Daniel J. Macqueen
bioRxiv 574384; doi: https://doi.org/10.1101/574384
S.H. Wood, M.M. Hindle, Y. Mizoro, Y. Cheng, B.R.C. Saer, K. Miedzinska, H.C. Christian, N. Begley, J. McNeilly, A.S. McNeilly, S.L. Meddle, D.W. Burt, A.S.I. Loudon
bioRxiv 2020.05.19.102194; doi: https://doi.org/10.1101/2020.05.19.102194