ASTI

Arctic Seasonal Timekeeping Initiative - a UiT Aurora Centre

About

ASTI is a capacity-building project to establish UiT as a centre of excellence for research into seasonal timekeeping mechanisms. This fills a strategic gap in chronobiology research worldwide, and is an excellent fit to UiT as the world’s northernmost research university.

ASTI will combine excellence in genome-enabled approaches to define the genetic basis of seasonal timer mechanisms (transcriptomics, comparative genomics, epigenomics, gene targeting), with state of the art approaches to in-vivo analysis of seasonal changes in physiology and behaviour (microdialysis, metabolomics, endocrinology, telemetry), and integration of complementary approaches through data processing capacity (mathematical network modelling, database management and data sharing).

ASTI will cover three overlapping themes spanning both basic and applied / societally important aspects: ‘Core seasonal timer mechanisms’, ‘Comparative seasonal chronobiology’ and ‘One seasonal health’.

ASTI will enhance awareness and understanding of the importance of seasonal timekeeping mechanisms for the health and wellbeing of humans and animals living in the Arctic region.

The centre project period is 1st April 2021 to 31st March 2025. The centre director is Professor David Hazlerigg and deputy director is Dr. Shona Wood. The centre is based within the research group Arctic chronobiology and physiology at the Department of Arctic and Marine biology.

Research themes


Specific research projects



News




People


Scientific advisory board


Events

ASTI LAUNCH 1st April 2021

Winter/Spring 2021 seminar program

Join seminar by zoom

19/02/2021 13:15

Fredrik Markussen, Arctic chronobiology and physiology, UiT

New PhD project description: Torpor-arousal cycling during hibernation

26/02/2021 13:15

Shona Wood, Arctic chronobiology and physiology, UiT

New paper: The circadian and epigenetic basis of photoperiodic time measurement in mammals

05/03/2021 12:15

Laura van Rosmalen, Institute for evolutionary life science, University of Groningen

Guest speaker: Seasonal modifiers of reproduction and ultradian behaviour in voles

09/04/2021 12:15

Jayme Van Dalum, Arctic chronobiology and physiology, UiT

Paper in preparation: Photoperiodic responses in voles

Publications 

List of key publications from 2020 onwards:

Neuroendocrine Clocks and Calendars, Editors: Ebling, Francis J. P., Piggins, Hugh D. (Eds.)

- An up-to-date and authoritative textbook explaining the mechanisms by which biological rhythms affect physiology and behaviour major contributions from key members of ASTI: Shona Wood, David Hazlerigg and Alex West

Markussen, F.A., Melum, V.J., Bothorel, B. et al. A refined method to monitor arousal from hibernation in the European hamster. BMC Vet Res 17, 14 (2021). https://doi.org/10.1186/s12917-020-02723-7

Striberny, A., (...) Hazlerigg, D.G., Jørgensen, E.H., Author links open overlay panelStriberny, A., … Hazlerigg, D.G, Jørgensen, E.H.Striberny, A., … Hazlerigg, D.G, Jørgensen, E.More than one way to smoltify a salmon? Effects of dietary and light treatment on smolt development and seawater growth performance in Atlantic salmon. Aquaculture 532, 15 (2021), 736044 (2021). https://doi.org/10.1016/j.aquaculture.2020.736044 

Laura van RosmalenJayme van DalumDavid G. HazleriggRoelof A. Hut Gonads or body? Differences in gonadal and somatic photoperiodic growth response in two vole species 

West AC, Iversen M, Jørgensen EH, Sandve SR, Hazlerigg DG, Wood SH (2020) Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genet 16(10): e1009097. https://doi.org/10.1371/journal.pgen.1009097

Wood, S.H., Hindle, M.M., Mizoro, Y. et al. Circadian clock mechanism driving mammalian photoperiodism. Nat Commun 11, 4291 (2020). https://doi.org/10.1038/s41467-020-18061-z

Daniel AppenrothVebjørn J. Melumet. al Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird 

https://doi.org/10.1371/journal.pone.0227496

Cristina Sáenz de Miera (...) David G. HazleriggValerie Simonneaux, Photoperiodic regulation in a wild-derived mouse strain 

Pre-prints

Gonads or body? Differences in gonadal and somatic photoperiodic growth response in two vole species

Laura van Rosmalen, Jayme van Dalum, David G. Hazlerigg, Roelof A. Hut 

bioRxiv 2020.06.12.147777; doi: https://doi.org/10.1101/2020.06.12.147777

 

A single nuclei transcriptomic analysis of the Atlantic salmon gill through smoltification and seawater transfer

Alexander C. West, Yasutaka Mizoro, Shona H. Wood, Louise M. Ince, Marianne Iversen, Even H. Jørgensen, Torfinn Nome, Simen Rød Sandve, Andrew S. I. Loudon, David G. Hazlerigg

bioRxiv 2020.09.03.281337; doi: https://doi.org/10.1101/2020.09.03.281337

 

Adaptive value of circadian rhythms in High Arctic Svalbard ptarmigan

Daniel Appenroth, Gabriela C. Wagner, David G. Hazlerigg, Alexander C. West

bioRxiv 2020.08.17.254011; doi: https://doi.org/10.1101/2020.08.17.254011

 

A refined method to monitor arousal from hibernation in the European hamster

Fredrik A. S. Markussen, Vebjørn J. Melum, Béatrice Bothorel, David G. Hazlerigg, Valérie Simonneaux, Shona H. Wood

bioRxiv 2020.04.20.009712; doi: https://doi.org/10.1101/2020.04.20.009712

 

Diversified regulation of circadian clock gene expression following whole genome duplication

Alexander C. West, Marianne Iversen, Even H. Jørgensen, Simen R. Sandve, David G. Hazlerigg, Shona H. Wood

bioRxiv 2020.03.22.002162; doi: https://doi.org/10.1101/2020.03.22.002162

 

Photoperiodic induction without light-mediated circadian entrainment in a high arctic resident bird

Daniel Appenroth, Vebjørn J. Melum, Alexander C. West, Hugues Dardente, David G. Hazlerigg, Gabriela C. Wagner

bioRxiv 2020.06.19.160721; doi: https://doi.org/10.1101/2020.06.19.160721

 

Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)

Marianne Iversen, Teshome Mulugeta, Alexander West, Even Jørgensen, Samuel A. M. Martin, Simen Rød Sandve, David Hazlerigg

bioRxiv 2020.03.24.006510; doi: https://doi.org/10.1101/2020.03.24.006510

 

Phylogenetic reclassification of vertebrate melatonin receptors to include Mel1d

Elsa Denker, Lars O. E. Ebbesson, David G. Hazlerigg, Daniel J. Macqueen

bioRxiv 574384; doi: https://doi.org/10.1101/574384

 

Circadian clock mechanism driving mammalian photoperiodism

S.H. Wood, M.M. Hindle, Y. Mizoro, Y. Cheng, B.R.C. Saer, K. Miedzinska, H.C. Christian, N. Begley, J. McNeilly, A.S. McNeilly, S.L. Meddle, D.W. Burt, A.S.I. Loudon

bioRxiv 2020.05.19.102194; doi: https://doi.org/10.1101/2020.05.19.102194

 

 

ASTI – Arctic Seasonal Timekeeping Initiative - a UiT Aurora Centre


ASTI
AAB building, Department of Arctic and Marine Biology
UiT – The Arctic University of Norway Tromsø, NO-9037, Norway
david.hazlerigg@uit.no

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