Epithelial-mesenchymal transition (EMT) in mammary epithelial cells

The aim of this project is to identify and characterize long non-coding RNAs (lncRNAs) with regulatory functions in epithelial-mesenchymal transition (EMT). We have performed whole-transcriptome RNA sequencing of 3 mammary EMT cell models (MCF10A, HMLE, and D492). Several EMT-associated lncRNAs have been identified that are abnormally expressed in breast cancer. We are particularly interested in the role of NEAT1 and paraspeckles in EMT and mammary gland biology. 


Maria Perander (Principal investigator)
Stephanie Rose Nielsen