Gene expression signatures in mammary EMT
We have performed whole transcriptome sequencing of 3 mammary EMT cell line models (MCF10A, HMLE, and D492) and substracted a core mammary EMT siganture that separates basal-like breast cancers into subclasses. We are currently studying lncRNAs with potential regulatory roles in EMT and breast cancer.
Key publications:
Knutsen, E., Das Sajib, S., Fiskaa, T., Lorens, J., Gudjonsson, T., Mælandsmo, G. M., Johansen S. D., Seternes O., Perander, M. 2023. Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes. Front Oncol. 13:1249895. doi: 10.3389/fonc.2023.1249895
Gabriel, M. T., Tekpli, X., Reine T. M., Hegge, B., Nielsen, S. R., Chen, M., Moi, L., Normann L. S., Busund L. T. R., Calin, G. A, Mælandsmo, G., M., Perander, M., Theocharis, A. D., Kolset S. O., and E Knutsen. 2022. Serglycin is involved in TGF-β induced epithelial-mesenchymal transition and is highly expressed by immune cells in breast cancer tissue. Front Oncol.12:868868. doi: 10.3389/fonc.2022.868868
Tellez-Gabriel, M., Knutsen, E., and M. Perander. 2020. Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies. Int J Mol Sci 21:9457. doi: 10.3390/ijms21249457