Human Lupus Nephritis

We do translational and clinical research on the autoimmune disease Systemic Lupus Erythematosus (SLE) aimed at identifying novel biomarkers and therapy targets 

SLE is a systemic autoimmune chronic inflammatory disease that is characterized by prolonged morbidity and substantial mortality. It has a predominant occurrence in females compared to men (9:1), and over 80% of SLE cases occur in women in their childbearing age. Lupus nephritis is a chronic kidney disease and a serious manifestation of SLE. We aim to develop new therapeutic tools and ways to monitor the disease based on novel and precise knowledge of the disease initiation and development. Since the expression of both DNase I and neutrophil extracellular traps (NETs) are abnormal in SLE, we hypothesize that they can be utilized in therapy and as biomarkers. To explore this, we will investigate the expression pattern and regulation of DNase I and NETs.


Hege Lynum Pedersen (Principal investigator)
Susannah von Hofsten
Aud-Malin Karlsson Hovd
Kristin Andreassen Fenton
Premasany Kanapathippillai
Anita Ursvik