Tissue engineering, organ-on-a-chip and inflammation resolution

Our research interest is mainly focused on regenerative medicine with different combination of biomaterials and cells, we are establishing an organ-on-a-chip platform for many possible applications.

Tissue engineering brings the concept of combination of different biomaterials, cells and growth factor under different culture conditions.  Several factors have been tested during the past years, however, there are still many conditions to be optimized with the development of new biomaterials before clinical application. Inflammation during the regeneration procedure is one of our goals. Resolvins are biosynthesized from omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in vivo by means of enzymatic activities, and these factors can attenuate inflammation and promote tissue regeneration. We have performed several studies recently about the application of Resolvins and effects on different cells that related to oral diseases.

Now we are mainly focused on establishing of different organ-on-a-chip models with a pump system for different applications, such as establishing of different oral tissue and cancer models.  We are testing different membrane and gel materials for application in organ-on-a-chip technology.

Together with our group members,  we also study the oral manifestations of systemic lupus erythematosus.


Zhe Xing (Principal investigator)
Premasany Kanapathippillai