Lupus Nephritis-disease mechanisms, detection and therapy


This translational and clinical project aims to obtain profound knowledge of the mechanisms behind SLE and LN in order to develop new and better disease monitoring, biomarkers and therapies. The project has a primary focus with three connected objectives each presented with its hypothesis, theory and aims:

 



Primary focus:

To develop new diagnostic and treatment strategies for SLE and LN patients

Objectives:

1.      We will elucidate the role of glomerular (endothelial and mesangial) damage during the development of LN

2.      We will determine the effect of tubular cells, macrophages, dendritic cells and intrinsic immune cells in interstitial inflammation

3.      We will determine the initiation of tertiary lymphoid structures in LN

 

We use lupus prone and inducible mouse models and biopsies from SLE patients to investigate the mechanisms of lupus nephritis in SLE. We analyze autoantibody composition, immune complex deposition, activation of both innate and adaptive immune cells, and the effect of inflammation on tissue specific cells. We use flow cytometry, immunohistochemical and fluorescent analyses, and immune electron microscopic analyses of cells and tissue in addition to gene expression analyses. Foto: Kristin Fenton


Medlemmer:

Kristin Andreassen Fenton (Principal investigator)
Simin Jamaly
Hege Lynum Pedersen (Principal investigator)
Premasany Kanapathippillai
Anita Ursvik
Aud-Malin Karlsson Hovd
Almudena Tello Martin
Thea Ekrem Skagen


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