Microalgae & Microbiomes

The M2 Research Group

The M2 Research Group (M2RG) specializes in using multi-omics, ecology and advanced cultivation for translating fundamental biology into new engineering design principles related to carbon capture, bioproducts and other sustainability issues.

We study marine microalgae, complex microbial communities and non-traditional hosts for the purposes of biodesign and control.

Founded in 2019, the M2RG is in the Norwegian College of Fishery Sciences within the Faculty of Biosciences, Fisheries and Economics. Our team also coordinates activities related to greenhouse gas managment, within the Arctic Centre for Sustainable Energy - ARC.





Svenning, J.B.*, Vaskog, T., Campbell, K., Bæverud, A.H., Myhre, T.N., Dalheim, L., Forgereau, Z.L., Osanen, J.E., Hansen, E.H., Bernstein, H.C. (2024). Lipidome plasticity enables unusual photosynthetic flexibility in Arctic vs. temperate diatoms. Marine Drugs. https://doi.org/10.3390/md22020067


Chan, D.T.C., Baldwin, G.S., Bernstein, H.C.* (2023). Revealing the host-dependent nature of an engineered genetic inverter in concordance with physiology. BioDesign Research. https://doi.org/10.34133/bdr.0016

Aalto, N.J., Schweizer, H., Grann-Meyer, E., Krsmanovic, S., Svenning, J.B., Dalheim, L., Petters, S., Ingebrigtsen, R., Hulatt, C.J., and Bernstein, H.C.* (2023). Microbial community dynamics during a harmful Chrysochromulina leadbeateri bloom. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.01895-22 

Moran, J.J.*, Bernstein, H.C., Mobberley, J.M., Thompson, A.M., Kim, Y.M., Dana, K.L., Cory, A.B., Courtney, S., Renslow, R.S., Fredrickson, J.K., Kreuzer, H.W., and Lipton, M.S. (2023). Daylight-driven carbon exchange through a vertically structured microbial community. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2023.1139213

Sert, M.F.*, de Grot, T.R., Kekäläinen, T., Jänis, J., Schweitzer, H., Bernstein, H.C., Ferré, B., Gründger, F., Niemann, H. (2023). Elevated methane alters dissolved organic matter composition in the Arctic Ocean cold seeps. Frontiers in Earth Science. https://doi.org/10.3389/feart.2023.1290882


Aalto, N. J., Schweitzer, H.D., Krsmanovic, S., Campbell, K.C., Bernstein, H. C.* (2022). Diversity and selection of surface marine microbiomes in the Atlantic-influenced Arctic. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2022.892634

Phalak, P., Bernstein, H. C., Lindemann, S.R., Renslow, R.S., Thomas, D.G., Henson, M.A., Song, H-S.* (2022). Spatiotemporal metabolic network models reveal complex autotroph-heterotroph biofilm interactions governed by photon incidences. IFAC-PapersOnLinehttps://doi.org/10.1016/j.ifacol.2022.07.430

Lima, S., Lokesh, J., Schulze, P.S.C., Wijffels, R.H., Viswanath, K., Scargiali, F., Petters, S., Bernstein, H.C., Morales-Sanchez, D.,* (2022). Flashing lights affect the photophysiology and expression of carotenoid and lipid synthesis genes in Nannochloropsis gaditana. Journal of Biorechnology. https://doi.org/10.1016/j.jbiotec.2022.11.012

Beck, A.E., Pintar, K., Schepens, D., Schrammeck, A., Johnson, T., Bleem, A., Du, M., Harcombe, W.R.,  Bernstein, H. C., Heys, J.J., Gedeon, T., Carlson, R.P.* (2022). Environment constrains fitness advantages of division of labor in microbial consortia engineered for metabolite push or pull interactions. bioRxiv pre-printhttps://doi.org/10.1101/2022.01.19.477024 


Aalto, N. J., Campbell, K., Eilertsen, H. C., Bernstein, H. C.* (2021). Drivers of Atmosphere-Ocean CO2 Flux in Northern Norwegian Fjords. Frontiers in Marine Science. https://doi.org/10.3389/fmars.2021.692093

Schweitzer, H.D., Aalto, N.J., Busch, W., Chan, D.T.C., Chiesa, M., Elvevoll, E.O., Gerlach, R., Krause, K., Mocaer, K., Moran, J.J., Noel, J.P., Patil, S.K., Schwab, Y., Wijffels, R.H., Wulff, A., Øvreås, L., Bernstein, H.C.* (2021) Innovating carbon capture biotechnologies through ecosystem inspired solutions. One Earth. https://doi.org/10.1016/j.oneear.2020.12.006

Dalheim, L.*, Svenning, J.B., Olsen, R.L. (2021) In vitro intestinal digestion of lipids from the marine diatom Porosira glacialis compared to commercial LC n-3 PUFA productsPlos one. https://doi.org/10.1371/journal.pone.0252125

Dalheim, L.*, Svenning, J.B., Eilertsen, H.C., Vasskog, T. and Olsen, R.L. (2021). Stability of lipids during wet storage of the marine diatom Porosira glacialis under semi-preserved conditions at 4 and 20 C. Journal of Applied Phycologyhttps://doi.org/10.1007/s10811-020-02292-0

Osvik, R. D.*, Andersen, J.H., Eilertsen, H.C., Geneviere, A.-M., Hansen, E. H. (2021). Bioactivity of a Marine Diatom (Porosira glacialis [Grunow] Jörgensen 1905) Cultivated With and Without Factory Smoke CO2. Industrial Biotechnology. http://doi.org/10.1089/ind.2020.0031

Osvik, R. D.*, Ingebrigtsen, R.A., Norrbin, M.F., Andersen, J.H., Eilertsen, H.C., Hansen, E.H. (2021). Adding Zooplankton to the OSMAC Toolkit: Effect of Grazing Stress on the Metabolic Profile and Bioactivity of a Diatom. Marine Drugs. https://doi.org/10.3390/md19020087


Morales-Sánchez, D.*, Schulze, P.S., Kiron, V. and Wijffels, R.H. 2020. Temperature-dependent lipid accumulation in the polar marine microalga Chlamydomonas malina RCC2488. Frontiers in plant science. https://doi.org/10.3389/fpls.2020.619064

Svenning, J.B.*, Dalheim, L., Vasskog, T., Matricon, L., Vang, B., Olsen, R. L Lipid yield from the diatom Porosira glacialis is determined by solvent choice and number of extractions, independent of cell disruption. (2020) Scientific reports. https://doi.org/10.1038/s41598-020-79269-z

Khan, N., Yeung, E., Farris, Y., Fansler, S. J., & Bernstein, H. C.* (2020). A broad-host-range event detector: expanding and quantifying performance between Escherichia coli and Pseudomonas species. Synthetic Biologyhttps://doi.org/10.1093/synbio/ysaa002

Kessell, A.K., McCullough, H.C., Auchtung, J.M., Bernstein, H.C., Song, H-S.* (2020). Predictive interactome modelling for precision microbiome engineering. Current Opinion in Chemical Engineeringhttps://doi.org/10.1016/j.coche.2020.08.003

Zupanic, A., Bernstein, H. C., & Heiland, I. (2020). Systems biology: current status and challenges. Cellular and Molecular Life Scienceshttps://doi.org/10.1007/s00018-019-03410-z

Lee, J-Y, Haruta, S., Kato, S., Bernstein, H.C., Lindemann, S.R., Lee, D-Y., Fredrickson, J.K., & Song, H-S.* (2020). Prediction of Neighbor-dependent Microbial Interactions from Limited Population Data. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2019.03049


Bernstein, H.C.* (2019). Reconciling engineering and ecological design principles for building microbiomes. mSystems. https://doi.org/10.1128/mSystems.00106-19

Svenning, J. B.*, Dalheim, L., Eilertsen, H. C., & Vasskog, T. (2019). Temperature dependent growth rate, lipid content and fatty acid composition of the marine cold-water diatom Porosira glacialis. Algal researchhttps://doi.org/10.1016/j.algal.2018.10.009

Zengler, K., Hofmockel, K., Baliga, N.S., Behie, S.W., Bernstein, H.C., Brown, J.B., Dinney, J.R., Folge, S.A., Forry, S.P., Hess, M., Jackson, S.A., Jansson, C., Lindemann, S.R., Pett-Ridge, J., Maranas, C., Venturelli, O.S., Wallenstein, M.D., Shank, E.A., Northen, T.R.* (2019) EcoFABS: advancing microbiome science through standardized fabricated ecosystems. Nature Methods. https://doi.org/10.1038/s41592-019-0465-0 

Zegeye, E.K., Brislawn, J.C., Farris, Y., Fansler, S.J., Hofmockel, K.S., Jansson, J.K., Wright, A.T., Graham, E.B., Naylor, D., McClure, R.S.*, Bernstein, H.C.* (2019). Selection, succession and stabilization of soil microbial consortia. mSystems. https://doi.org/10.1128/mSystems.00055-19

Song, H-S.*, Lee, J-Y, Haruta, S., Nelson, W.C., Lee, D-Y., Lindemann, S.R., Fredrickson, J.K., Bernstein, H.C. (2019). Minimal Interspecies Interaction Adjustment (MIIA): inference of member-dependent interactions in microbiomes. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2019.01264

Brislawn, J.C., Graham, E.B., Dana, K., Ihardt, P., Fansler, S.J., Chrisler, W.B., Cliff, J.B., Stegen, J.C., Moran, J.J.*, Bernstein, H.C.* (2019). Forfeiting the priority effect: turnover defines biofilm community succession. The ISME Journal. https://doi.org/10.1038/s41396-019-0396-x

 Linn, V.S., Volk, R.F., DeLeon, A.J., Anderson, L.N., Purvine, S.O., Shukla, A.K., Bernstein, H.C., Smith, J.N., Wright, A.T.* (2019). Structure dependent determination of organophosphate targets in mammalian tissues using activity-based protein profiling. Chemical Research in Toxicology. https://doi.org/10.1021/acs.chemrestox.9b00344


Group Leader:
Hans Christopher Bernstein

The Arctic Centre for Sustainable Energy - ARC
Norwegian College of Fishery Sciences
Factuly of Biosciences, Fisheries and Economics - BFE

email: hans.c.bernstein(@)uit.no 
Twitter: @microbe_angler

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