DC14
Liver on-a-chip models for liver metabolic dysregulation research
Background: Imbalances in metabolic networks are increasingly recognized as potential targets in various liver diseases, including NAFLD and NASH, offering novel avenues for therapeutic interventions. Utilizing liver-on-a-chip models to investigate metabolic dysregulation in the liver offer a unique platform to simulate liver metabolism and study its dysregulation, providing critical insights for targeted treatments and drug development.
Objectives: (1) Develop 3D human (disease specific) models to mimic liver architecture and the NAFLD and NASH environment. (2) Develop liver-on-a-chip model-based readouts for hub molecules suitable for high-throughput screening; (3) Validate the model with tool compounds including nutraceuticals on 3D liver disease models.