Shedding light on Atlantic salmon Rab GTPases through various imaging approaches including conventional light and super resolution microscopy techniques as well as electron microscopy.
Rab GTPases comprise a multigene family of proteins which participate in regulation of almost all membrane trafficking processes in eukaryotic cells. Due to their implication in various biological processes and pathological conditions, Rab GTPases have been extensively studied in mammals; however, information about these proteins in lower vertebrates and, in particular, teleosts is scant.
The current project is aimed at shedding light on the properties of Atlantic salmon Rab5C, Rab7A and Rab27A. The research is focused on the potential of the salmon homologs to serve as markers for specific intracellular compartments, the regulation of their expression by immune stimuli and viral infections and their involvement in unconventional secretory pathways, including the generation and secretion of extracellular vesicles.
UiT Strategic Funding