ViVaAct: Comparing the protection of attenuated and inactivated virus vaccines against PD and HSMB


In Norwegian salmon farming, about 20% of the fish that are released in the sea do not reach the slaughter age.  Two  of the diseases causing outbreaks in Norwegian  farms are  Pancreatic Disease (PD) and Cardiovascular Muscle Inflammation (HSMI). In experimental immunization and challenge trials of short (min 6 weeks) and long (min 6 months) duration, we will investigate the protective effect of live and inactivated vaccines  against these diseases. A main focus for the NFH team is to characterise specific humoral and cellular responses to these vaccines.  We will specifically investigate B cells, that is, antibody producing cells, and the type of long-term protective effects these cells have. One important aim is to compare B cell responses in the systemic organs (head kidney and spleen) versus  the local response in the peritoneum,,wshere the vaccines are administered. In ViVaAct, methods including ELISpot, Flow cytometry analysis, RNAseq and epigenomics will be included.

Project ID Cristin: 642051

   



Members:

Espen Rimstad
Henriette Nordli
Ingvill Jensen
Guro Strandskog
Linn Greiner-Tollersrud
Jorunn Jørgensen


Financial/grant information:

 The Research Council of Norway:  Project No 200847