Investigating the Role of Lactate in Cardiac Function and Signaling

In this project we explore the multifaceted role of lactate in the heart, focusing on its dual function as a metabolic substrate and a signaling molecule. Traditionally viewed as a byproduct of anaerobic metabolism, lactate is now recognized as a key player in energy metabolism and intercellular communication. 

In this study we will investigate both lactate enantiomers L-lactate and D-lactate as an energy source for the heart and their role in supporting cardiac function during exercise and stress.

Additionally, we explore lactate’s signaling properties, particularly through the hydroxycarboxylic acid receptor 1 (HCAR-1), to understand how it influences cardiac adaptation and function. 

Methods include high-resolution respirometry (Oroboros), Langendorff perfusion experiments, working heart models, and RNA sequencing (RNA-seq). 

By integrating physiological and molecular approaches, this project seeks to provide a comprehensive understanding of lactate’s role in the heart, and the findings could have significant implications for improving our understanding of exercise physiology, cardiac adaptation, and potential therapeutic strategies targeting lactate metabolism and signaling in cardiovascular health and disease.

Members:

AD Hafstad (Co-PI)

OJ How (Co-PI)

A Fabrizius, GER  (Co-PI)

T Lund

S Wood (BFE).

UiT

Blix Fond