MitoLUPUS
Systemic lupus erythematosus (SLE) is a complex autoimmune disease primarily affecting young women, leading to diverse symptoms and serious complications, including cardiovascular diseases which are a major cause of death among SLE patients. The link between SLE and heart failure (HF), particularly the metabolic aspects, is not well understood. Whether early changes in cardiac and skeletal muscle function and metabolism occur in SLE, setting the stage for HF development before severe kidney issues arise is not known.
This project explores the cardiovascular and muscular changes in SLE using a mouse model, focusing on heart function and mitochondrial health in both cardiac and skeletal muscles. The goal is to identify early changes that may contribute to HF in SLE patients.
The research aims to enhance our understanding of how SLE affects the heart and muscles, potentially leading to new treatments. It also seeks to improve symptom management in SLE, particularly fatigue and heart issues, thus improving patient quality of life and reducing healthcare costs. Additionally, the study addresses gender differences in cardiovascular health, aiming to improve outcomes for women affected by SLE.
Collaboration with the RAMP group and the project: Lupus Nephritis-disease mechanisms, detection and therapy https://uit.no/research/ramp/project?pid=792372