Past Project

The effect of acute stressors on the diabetic heart, and the cardioprotective effect of exercise training (2008-2020)

This project was a continuation of research activity focusing on understanding the underlying mechanism of heart failure associated with obesity and diabetes. We have previously focused on the role of systemic factors - lipid oversupply, insulin resistance and inflammation - and how they can be attenuated by pharmacologic and lifestyle interventions (exercise, dietary supplementation).  The objectives of this project were to study the metabolic and mechanoenergetic changes in the diabetic heart during acute stresses (such as a high lipid load and/or ischemia-reperfusion), as well as the cardiopotective effect of exercise training.

Members: Ellen Aasum, Terje Larsen, Neoma Boardman, Anne Hafstad

Financial/grant information:

The Research Council of Norway (Post Doc/Hafstad), UiT- The Arctic University of Norway (PhD/Lund), NASAT-Unikard (Researcher/Boardman), Norwegian Health Association (PhD/Pedersen and Post Doc/Boardman). Running cost: UiT- The Arctic University of Norway, Helse Nord, Norwegian Health Association, NovoNordic Foundation, Norwegian Diabetes Association.

The project has led to 10 research publications, one review and 2 PhD thesis: doi:10.1152/ajpheart.00284.2020;  doi:10.3389/fphys.2019.01274; doi:10.1371/journal.pone.0204843; dio:10.1152/ajpheart.00382.2017; doi:10.1089/ars.2015.6304; doi:10.1152/ajpheart.00734.2014; doi:10.2337/db12-1580; doi:10.1152/ajpheart.01190.2010; doi:10.1152/japplphysiol.00594.2011; doi:10.1152/ajpheart.01264.2008; doi:10.1161/CIRCRESAHA.109.199810

PhD thesis: Tina Pedersen (2017); Jim Lund (2015)