Interplay between metabolism and signalling
It has long been known that metabolism is influencing signal transduction and gene regulation, but the underlying mechanisms are still poorly understood. Protein modifications are the basis for both signal transduction and gene regulation and their addition and removal require central metabolites that we call Hub Molecules of Life (HubMOL). Measuring the dynamics of protein modifications and metabolites allows to analyse the interplay between protein modifications and metabolism. We develop mathematical modelling approaches that allow data deconvolution and support mechanistic understanding of the interconnections between metabolism and signal transduction/gene regulation.
The models shall also be used to predict dietary responses as well as the impact of nutrition on treatments targeting respective pathways and thus help to develop new nutritional strategies to improve health and combat diseases.
Major publications
- Lena Elise Høyland, Magail vanLinden, Marc Niere, ... , Heiland, I, Ziegler, M Chronic depletion of subcellular NAD pools reveals their interconnectivity and a buffering function for mitochondria Nature Metabolism 2024 (6), 2319–
- Panitz et al. Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma Theranostics 2021 https://pubmed.ncbi.nlm.nih.gov/34646367/
- Prentzell et al. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signalling Cell 2021 184 (3), 655-674. e27
- Bockwoldt, M, Houry, D, Niere, Gossmann, TI, M, Reinhartz, I, Schug, A, Ziegler, M, Heiland, I Identification of evolutionary and kinetic drivers of NAD-dependent signalling PNAS 2019, 116 (32) 15957-15966
- Heberle, AM2, Razquin Navas, P2, … Heiland, I, Sascha Schäuble, Kathrin Thedieck The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner Life Science Alliance 2019 2 (2) e20180025
Members:
Financial/grant information:
Funded by the European union H2020-SC1 programm and Horizon Europe MSCA-DN programm