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Vår 2023

KJE-3201 Bioinorganic Chemistry - 10 stp


The course is administrated by

Institutt for kjemi

Type of course

Theoretical subject. The course is available as an elective independent of study program, and also to exchange students. The course is offered on condition that there is a minimum number of registered students.

Course overlap

KJE-8201 Bioinorganic chemistry 10 stp

Course contents

The course will present a mechanistic perspective of the role of metals and metalloids in biology. After a short introduction to metal ion storage, transport, and homeostasis, the course will progress to a detailed discussion of redox metalloenzymes, particularly dioxygen metabolism. Early discussions will focus on dioxygen transport (myoglobin, hemoglobin, hemerythrin, hemocyanin), superoxide metabolism (superoxide dismutase and superoxide reductase), enzymes utilizing peroxide (peroxidases and catalases), dioxygen-activating enzymes (monooxygenases and dioxygenases), and cytochrome P450. Subsequent topics for discussion will include selected redox cofactors, particularly those present in various copper proteins, cytochromes b and c, iron-sulfur clusters, cobalamins, and molybdenum cofactors. Particular emphasis will be placed throughout on electronic-structural and mechanistic insights afforded by synthetic model systems. The course will conclude with a discussion of special topics, which will vary from year to year, depending on the interests of course participants and on recent happenings in the field. Examples of such topics include NO biology, arsenic toxicity, metallodrugs such as platinum anticancer drugs and technetium radiopharmaceuticals, aspects of the origin of life, etc.

Application deadline

Applicants from Nordic countries: 1 June for the autumn semester and 1 December for the spring semester. Exchange students and Fulbright students: 1 October for the spring semester and 15 April for the autumn semester.

Admission requirements

Admission requires a Bachelor`s degree (180 ECTS) in Chemistry or equivalent. A thorough knowledge of elementary university-level organic and inorganic chemistry, corresponding to a grade of C or better in KJE-1002 and KJE-1004, will be assumed, as will a modest exposure to elementary biochemistry and NMR spectroscopy. A reasonable knowledge of elementary ligand field theory and organic reaction mechanisms will be assumed

Local admission, application code 9371 - singular courses at Master's level.


Objective of the course

The student should acquire the following knowledge, skills and competencies.

Knowledge

Skills

General competencies


Language of instruction

The language of instruction is English and course material will be in English.

Teaching methods

Formal lectures: 24 h; Group discussions: 12 h; self-study of assigned reading material, including book chapters and review articles.