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Vår 2020
KJE-3106 Biomolecular modelling - 10 stp
The course is administrated by
Institutt for kjemi
Type of course
Theoretical and practical course. The course is available as a singular or elective course independent of study program, also to exchange students. The course is offered on condition that a minimum number of students register for the course.
Course overlap
KJE-3001 Interdisciplinary molecular sciences: From quantum mechanics to medicine 10 stp
Course contents
Computer modeling and simulations have now become important tools to study complex systems in many areas of chemistry and biology. With todays high performance computers and advanced software it is possible to study the atomic level details of ribosomes and virus capsids, and to explore biological function with computational modeling. Computational modeling is frequently used to obtain novel insights into ligand binding and design, protein folding, enzyme catalysis and protein-membrane interactions. The course will introduce the basic concepts of computer modeling techniques with main focus on molecular interactions:
- Intermolecular forces
- Molecular mechanics
- Energy minimization
- Molecular dynamics simulations
- Monte Carlo simulations
- Solvation models
- Free energy calculations and ligand binding
- Enzyme catalysis
Application deadline
Applicants from Nordic countries: 1 December for the spring semester. Exchange students and Fulbright students: 1 October for the spring semester
Admission requirements
Required:
- A bachelor degree in chemistry or equivalent, with a grade C or better in the Norwegian grading system
Recommended:
- KJE-1005, or equivalent
Objective of the course
The candidate will have acquired a solid and broad theoretical basis to understand and carry out biomolecular modelling chemistry. This means that the student:
Knowledge:
- Understands the principles of biomolecular modelling
- Has knowledge of how to apply biomolecular modelling methods
- Understands the limitation of biomolecular modelling
Skills:
- Can discuss and evaluate theoretical predictions with experimental data
- Can conduct independent modeling of binding affinities
- Can make models of biological complexes
- Can analyze the results from the biomolecular modelling data
Competence:
- Understands the relationship between molecular structure and function in biological systems
- Can apply his/her knowledge and skills to solve relevant problems
- Has knowledge to search the literature to present a chosen subject at the research front both written and orally
- Can write concise reports
- Can communicate both in writing and orally terms, theories and problems related to the methods
Language of instruction
The language of instruction is English and all of the syllabus material is in English.
Teaching methods
Lectures: 30 h
Seminars/exercises: 40 h
Assessment
A final oral exam at the end of the course. Passed/not-passed.
Candidates who receive the grade F can repeat the oral exam the following semester.
Coursework requirements: Five approved practical exercises
Date for examination
Oral examination 04.06.2020
The date for the exam can be changed. The final date will be announced at your faculty early in May and early in November.