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Høst 2019
KJE-3402 Protein Structure - 10 stp
The course is administrated by
Type of course
Course overlap
Course contents
Application deadline
Applicants from Nordic countries: 1 June for the autumn semester
Exchange students and Fulbright students: 15 April for the autumn semester.
Admission requirements
Formal prerequisites:
- A bachelor degree in chemistry, biochemistry or equivalent, with a grade C or better in the Norwegian grading system.
Objective of the course
The student will have acquired a solid and broad theoretical basis to understand protein structure. This means that the student:
Knowledge:
Properties of amino acids
- has extensive knowledge about the molecular structure of the natural amino acids
- has in-depth knowledge about the chemical and structural properties of the individual amino acids both in their free form and in a protein
- has insight into the properties of the peptide and the peptide bond and how these properties influence the folding and structure of a protein
- has knowledge about the main intramolecular forces involved in the stabilization of proteins; their origin, magnitude and role in proteins
Structural hierarchy and structural diversity
- has knowledge about the main structural levels in proteins; primary, secondary, tertiary and quaternary
- has insight into how structural elements like secondary structures, motives and folds are built and stabilized
- knows about and can distinguish between globular, membrane bound and fiber proteins and can relate the classes to structural features
- has knowledge about classification of proteins based on both function and structure
- has insight into the main functional protein classes and has detailed knowledge about structure-function relationships for typical example proteins for every functional class
Binding sites and intramolecular interactions
- has knowledge about general mechanisms for ligand binding and intermolecular interactions; enzymes active sites and enzyme catalysis, antibody binding sites, protein-DNA interactions, receptor binding responses in signalling etc.
Methods for obtaining structural information
- knows the most important techniques for determination and analyses of 3-dimentional structures at atomic resolutions; their major strengths and limitations and the interpretation of deposited structural information in the relevant data banks
Skills:
- can describe the properties of the amino acids, peptides, secondary structure elements and motifs, and are able to evaluate their impact and role at various placements in a protein structure
- can outline in details the structure and stabilizing factors of frequently occurring secondary structure elements, motives and folds
- can describe key features of proteins belonging to various functional classes in general terms and describe such features specifically for example proteins for each functional class
- has acquired the basic knowledge to understand how the atomic resolved protein structure is determined and is able to sketch and understand the main steps in the procedure for determine structures by the use of NMR and X-ray crystallography
- can outline the main steps in a molecular modelling procedure and understands the pitfalls and limitations of a modelled structure
- can interpret and manipulate electronic three-dimensional models from a PDB file
Competence:
- understands the relation between chemical/structural properties of a protein and the function, and can use this knowledge to discuss and interpret structure-function relations
- has the ability to read and understand in general terms, research papers where the structure-function relationships of a protein are discussed
Language of instruction
Teaching methods
Assessment
A final 4h written exam counting 100%. Lettergrades A-E, F-Fail.
Coursework requirements: Compulsory attendance for five practical exercises. One approved project report.
There will not be arranged a re-sit exam for this course.
Date for examination
The date for the exam can be changed. The final date will be announced at your faculty early in May and early in November.