KJE-8403 Crystallography I - 10 stp

Starting in 1901, and including 2003, 2006, 2009, 2011, and 2012, more than 15 scientific Nobel Prizes have substantially advanced or involved X-ray crystallography and its ability to determination the three dimensional structures of molecules of any size at atomic resolution. This reflects the central role crystallography continues to play in revealing the structural origins of molecular properties, enabling practical applications ranging broadly, from semiconductor design to drug discovery.

This course gives students both a theoretical foundation of, and practical experience with, modern crystallography. The content involves both theory and experiment, spanning technologies from the generation of X-rays and crystallization of compounds and macromolecules to the determination and evaluation of their molecular structures. Lectures are accompanied by a one week intensive course in crystallization and a research project designed to complement the student's research interests.

The course will be presented in 3 sections: (i) Practical and theoretical introduction to methods for the crystallisation of small molecules and biological macromolecules. (3 credits). (ii) Basic crystallography, diffraction and the measurement and processing of diffraction data. (4 credits). (iii) Structure determination. (3 credits).

The first section of the course can be offered as a separate unit of 3 credits (KJE-8703).

Registration deadline for PhD students at UiT - The Arctic University of Norway: September 1st

Application deadline for other applicants: June 1st

PhD students or holders of a Norwegian master´s degree of five years or 3+ 2 years (or equivalent) may be admitted. Valid documentation is a statement from your institution that you are a registered PhD student, or a Master´s Diploma with Diploma Supplement / English translation of the diploma. PhD students are exempt from semester fee.

Holders of a Master´s degree must upload a Master´s Diploma with Diploma Supplement / English translation of the diploma. Applicants from listed countries must document proficiency in English. To find out if this applies to you see the following list:

Proficiency in English must be documented - list of countries

For more information on accepted English proficiency tests and scores, as well as exemptions from the English proficiency tests, please see the following document:

Proficiency in english - PhD level studies

Students should have basic knowledge in chemistry (atomic and molecular structure), biochemistry (protein structure), and mathematics (calculus). Basic knowledge in physics (electromagnetic radiation, wave mechanics) is recommended.

PhD students at UiT The Arctic University of Norway register for the course through StudentWeb .

Other applicants apply for admission through SøknadsWeb. Application code 9303.

Applicants who are not PhD students at UiT must attach a confirmation of their status as a PhD student from their home institution. Students who hold a Master of Science degree, but are not yet enrolled as a PhD-student have to attach a copy of their master's degree diploma. These students are also required to pay the semester fee.

More information regarding PhD courses at the Faculty of Science and Technology is found here.

The candidate will acquire a solid and broad theoretical and practical basis to understand and perform modern crystallographic structure determination. This will be accompanied by focussed topical studies from a practical lab project in crystallization and an additional project, either experimental or computational, chosen to match specific research interests and goals of the student.

The successful student will:

Knowledge

Fundamentals of crystallography

• Understands the phase problem of crystallography
• Can develop an intuitive understanding of the Fourier transform as applied in crystallography
• Understands the basis of X-ray diffraction based on Bragg's law
• Knows the symmetries and point groups of periodic crystals
• Knows the mathematical relationships between the spatial distribution of electron density, crystal lattices, Miller planes, and experimentally observed diffraction patterns.
• Knows how to evaluate the accuracy of X-ray crystal structure models

Practical structure determination

• Has thorough knowledge of the structure determination process from start to finish
• Has thorough insight into the information required for successful structure solution
• Has thorough experience with relevant software and webservers.

Crystallization

• Has basic knowledge and experience regarding crystallization methods and necessary prerequisites

Skills

• Knows how to design advanced crystallization experiments
• Is trained to independently carry out X-ray data collection experiments
• Knows how to run a crystallographic structure solution software suite to perform all necessary structure solution steps.
• Has extensive knowledge of key informational and service webservers in crystallography.

General competence

• Has a thorough overview of the entire structure solution process
• Has a thorough understanding of the accuracy and relevance of crystal structures, and how this can be applied in a scientific context
• Knows how to interpret, analyse and present crystallographic research results

Grades based on a final, oral examination. Lettergrades (A-F). Coursework requirements: Admission to the examination requires that the practical parts of the course have been completed and reported satisfactorily. 

There will not be arranged a re-sit exam for this course.