Master of Science Amudha Deepalakshmi Maharajan will Friday January the 27th 2023 at 11:15 hold her disputas for the PhD degree in Science:
"AHL-mediated quorum sensing regulation: Role in controlling cytotoxicity, T6SSs and CRISPR-Cas systems in Aliivibrio wodanis"
Aliivibrio wodanis has been associated with winter ulcer disease outbreaks. It has been reported that A. wodanis may act as a secondary pathogen in disease outbreaks and pathogenesis. The culture supernatant of A. wodanis causes a cytopathogenic effect (CPE) in various salmon cell lines. Moreover, in an Atlantic salmon bath challenge experiment, A. wodanis alone produces clinical symptoms in the fish. However, the contribution of A. wodanis to winter ulcer disease is not clear. Despite the knowledge to date and the research done in the field, there are still unanswered questions and a knowledge gap. Several Vibrio and Aliivibrio species use quorum sensing (QS) to regulate genes connected to host-pathogen interaction, virulence, survival, and adaptation mechanisms. In other aliivibrios, several QS systems, including the ainS/AinR and a transcriptional regulator litR (LuxR homologs), have been reported to regulate various phenotypic traits.
Professor Arne Smalås, Dekan for Fakultet for naturvitenskap og teknologi, UiT, leder disputasen.
Prøveforelseninga strømmes fra: her.
Disputasen strømmes fra: her.
Lenke til avhandling: her.