Disputas – Cand.med Evgeniya Sovershaeva
Cand.med Evgeniya Sovershaeva disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“HIV-infection in children and adolescents in Zimbabwe: viral suppression, airway abnormalities and gut microbiota”.
Kort populærvitenskapelig sammendrag av avhandlingen:
Sub-Saharan Africa has the highest HIV burden in the world. Antiretroviral therapy (ART) improves survival by suppressing HIV in the blood.
Data suggest that children living with HIV are prone to chronic lung complications.
In this work we analyzed the factors that may contribute to the development of these complications.
In Paper I, we found that it is harder to achieve suppression of HIV in children. Moreover, even after virus was under control, relapses were more common in children than in adults.
In paper II and III we investigated the role of two components of the immune system -exhaled NO (eNO) and gut microbiota. eNO level was affected by presence of HIV and previous tuberculosis. While HIV-infected participants had altered gut microbiome in general, ART had a positive effect on its composition. No association was found between lung disorders and gut microbiota.
Children living with HIV present a distinct challenge, and more resources should be directed to management of those patients.
Veiledere Hovedveileder Professor Jon Øyvind Odland, Institutt for samfunnsmedisin, UiT Norges arktiske universitet
Senior Clinical Lecturer Dr. Derek Sloan, University of St Andrews in Scotland, UK– 1. opponent Professor Anne Margarita Dyrhol Riise, UiO – 2. opponent
Førsteamanuensis Ellen Berit Nordal, UiT Norges arktiske universitet – leder av komité
Førsteamanuensis Morten Skandfer, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted:
“Achieving Sustainable Development Goals for Children: Key challenges to meet international health targets by 2030”