Master of Science in Biomedicine Md Ashraful Islam disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
“Biology of mesenchymal stromal cells: Chondrogenesis, paracrine signalling and cartilage repair”
Kort sammendrag av avhandlingen:
Articular cartilage lesions lead to swelling of the synovial joint, debilitating pain, functional impairment, and eventually osteoarthritis. The use of mesenchymal stem/stromal cells (MSCs) has demonstrated as an attractive cell source for cartilage repair due to their multilineage differentiation potential and hypoimmunogenic properties. Despite the advances in cartilage repair techniques, there is no consensus relating to the most suitable cell type for cartilage repair or osteoarthritis treatment. The overall aim of this thesis was to investigate and compare the chondrogenic capacity, and paracrine signalling potential of human MSCs harvested from adult knee joint and young umbilical cord to find a suitable source for cartilage repair. Additionally, we also used several approaches to gather new knowledge about cell-based biomarkers to predict clinical outcomes after cell transplantation procedures.
Veiledere
Hovedveileder professor Inigo Martinez
Biveileder førsteamanuensis Gunnar Knutsen
Bedømmelseskomiteen
Professor Ernst Hunziker, Department of Osteoporosis and Orthopaedic Surgery, Inselspital, Bern University,Sveits – 1. opponent
Researcher Karina Wright, ISTM Keele University; RJAH Orthopeadic Hospital, England – 2. opponent
Professor Ugo Moens, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder
Førsteamanuensis Ole K. Grønli, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “The regeneration of articular cartilage ”is not an ideal of reason, but of imagination* ”
* Immanuel Kant (Fundamental Principles of Metaphysics of Ethics)