Cand.med. Thea Grindstad disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:
Kort sammendrag av avhandlingen:
Today, Prostate cancer is the most frequent occurring cancer amongst men in Norway.
The dilemma with prostate cancer is that it can develop in several ways. It can remain "silent", never giving the patient any complaints, and the patient will eventually die from other causes that the disease. Or it can be an aggressive cancer; quickly spreading and greatly affecting the patient's life quality, eventually resulting in death. So far, no optimal way to predict how the specific prostate cancer will develop has been discovered. We sought to bring insight to this subject by investigating the influence of specific steroid hormone receptors on prostate cancer progression. Steroid hormones constitute an important signaling system in the human body. They do their job by stimulating their own receptors, located in cells throughout the whole body. This is similar to a key in a lock, where the key is the hormone and the lock the receptor. Several of such steroid hormone receptors are connected to cancers. We evaluated the receptors' presence in prostate cancers that had been surgically removed, in addition to evaluating how the patient's cancer had developed. Our discoveries indicate that these receptors can predict how the prostate cancer will progress. This knowledge can improve risk groups for prostate cancer patients, which in turn can benefit treatment decisions. (Avhandlingen er tilgjengelig for utlån hos Seksjon for forskningstjenester frem til disputasdato)
Veiledere
Hovedveileder førsteamanuensis Elin Richardsen
Biveileder postdoktor Samer Al-Saad
Biveileder professor Lill Tove Rasmussen Busund
Biveileder professor Roy Martin Bremnes
Biveileder postdoktor Sigve Andersen
Bedømmelseskomiteen
Professor Ian G Mills, Movember Centre of Exellence for Prostate Cancer Research, Centre for Cancer Research and Cell Biology, Queen’s University Belfast, United Kingdom. – 1. opponent
Professor Marene Landström, Dept. of Medical Bioscience, Faculty of Medicine, University of Umeå, Sweden. – 2. opponent
Førsteamanuensis Anne-Sofie Furberg, Institutt for samfunnsmedisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité
Disputasleder
Professor Ørjan Olsvik, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet
Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: “Contributions of nuclear hormone receptors to health and disease”