Life-style factors and VTE


In contrast to coronary artery disease (e.g. myocardial infarction), the incidence of venous thromboembolism (VTE) has not declined during the last decades. In order to reduce the incidence of VTE in the population, it is important to identify how health behaviours such as education level, physical activity, diet, coffee, and tobacco and alcohol habits affect the incidence of VTE.

Lifestyle (MostPhotos.com)

In this project, we investigate the associations between various health behaviours (physical activity and muscle strength, smoking, dietary habits etc.) and the risk of VTE in large population-based cohorts (Tromsø and HUNT studies). Information on health behaviours were largely assessed by self-administered questionnaires, and we have established well-validated outcome registers for VTE during follow-up in our cohorts.

Fatty acids (MostPhotos.com) 

IMPROVE project: Profiling of serum metabolites (the serum metabolome) may provide an opportunity to address important gaps in knowledge on the pathophysiological mechanisms of VTE, with the potential to identify novel biomarkers and unravel causal pathways. We will integrate data from a metabolome platform with genomic data in order to investigate biological pathways that underlie metabolite regulation of the VTE pathophysiology.

Principal Investigator: John-Bjarne Hansen

External collaborators: Kristian Hveem, Ben BrumptonBjørn Olav Åsvold (HUNT Center for Clinical and Molecular Epidemiology), Melliane Muteba Olsen, Kjersti Grønning (Nord-Trøndelag Hospital Trust), Magdalena Johansson (Umeå University),George Davey-Smith, Nicholas Thompson, Kaitlin H. Wade (University of Bristol)

Publications:

Leknessund et al. Hand grip strength and risk of incident venous thromboembolism: The Tromsø study. RPTH 2022.

Leknessund et al. Hand grip strength in venous thromboembolism: risk of recurrence and mortality

Evensen et al. Cardiorespiratory fitness and future risk of venous thromboembolism. J Thromb Haemost. 2019;17:2160-8.

Evensen et al. Physical activity and risk of recurrence and mortality after incident venous thromboembolism. J Thromb Haemost. 2019;17:901-11.

Isaksen et al. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thromb Haemost. 2019;119:2053-63.

Isaksen et al. Dietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolism. Res Pract Thromb Haemost. 2019;3:59-69.

Evensen et al. Regular Physical Activity and Risk of Venous Thromboembolism. Semin Thromb Hemost. 2018;44:765-79.

Evensen et al. Repeated assessments of physical activity and risk of incident venous thromboembolism. J Thromb Haemost. 2018.

Hansen-Krone et al. High fish plus fish oil intake is associated with slightly reduced risk of venous thromboembolism: the Tromso Study. J Nutr. 2014;144:861-7.

Brodin et al. Serum levels of vitamin D are not associated with future risk of venous thromboembolism. The Tromso Study. Thromb Haemost. 2013;109:885-90.

Enga et al. Cigarette smoking and the risk of venous thromboembolism: the Tromso Study. J Thromb Haemost. 2012;10:2068-74.

Hansen-Krone et al. Heart healthy diet and risk of myocardial infarction and venous thromboembolism. The Tromso Study. Thromb Haemost. 2012;108:554-60.

Hansen-Krone et al. Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism - the Tromso Study. Thromb Haemost. 2011;106:272-8.

Enga et al. Coffee consumption and the risk of venous thromboembolism: the Tromso study. J Thromb Haemost. 2011;9:1334-9.

Borch et al. Physical activity and risk of venous thromboembolism. The Tromso study. Haematologica. 2010;95:2088-94.



Members:

John Bjarne Hansen
Sigrid Kufaas Brækkan
Oda Gabrielle R. Leknessund