Previous studies have shown that obesity is associated with risk of future VTE. In this project, we aim to further elaborate on the relationship between obesity and VTE. Our long-term goal is to improve risk stratification for VTE in obesity and to identify molecular targets for intervention to prevent obesity-related VTE.
Obesity has a substantial impact on VTE risk in the population (Illustration: MostPhotos.com)
In this project, we explore the linearity of the relationship between body mass index (BMI) and VTE risk as well as the impact of weight gain on VTE risk. We investigate the role of obesity-related cardiometabolic risk factors on the VTE risk and explore the combined effect of obesity and other genetic and environmental factors (life-style factors, comorbidities, etc.) on VTE risk. Furthermore, we study the association between adipose-tissue specific proteins and VTE risk (using targeted and proteome-wide approaches) and investigate their influence on VTE risk (mediation analyses) in obesity.
Principal Investigator: John-Bjarne Hansen
External collaborators: Tom Wilsgaard and Inger Njølstad (Department of Community Medicine, UiT), Ellisiv B. Mathiesen (Department of Clinical Medicine, UiT)
