Extracellular cyclic cGMP as a biomarker for effect of treatment (cytotoxic drugs and radiation) on gynecologic cancers

Several recent studies of cervical cancer have shown that the cGMP signal pathway is of crucial importance in development and progression of human cervical cancer. We have previously shown that patients with increasing urinary cGMP levels after treatment indicate relapse. Translation studies in vitro and in vivo may lead to improve the treatment of gynecologic cancers.