The overarching purpose of the project is to investigate potential associations between retinal thickness, retinal vasculature and retinopathy and cardiovascular risk factors and diseases such as stroke and dementia.
The overarching purpose of the project is to investigate potential associations between retinal thickness, retinal vasculature and retinopathy and cardiovascular risk factors and diseases such as stroke and dementia.
The project is a part of the The Tromsø Eye Study, a sub-study of the population-based Tromsø Study. Imaging of both eyes was performed in the 6th (2006-2007) and 7th survey (2015-2016). The retinal photographs were graded for retinopathy. Retinal vessel calibers were measured computer assisted on retinal photographs and retinal thickness was measured on optical coherence tomography.
Retinal microvascular abnormalities and future risk of stroke
The overall aim of the project is to investigate the association between retinal microvascular abnormalities and cerebral white matter hyperintensities on MRI and future risk of stroke in a general population, based on data from the Tromsø Eye Study and the Gutenberg Health Study. We also aim to develop novel stroke risk prediction models including retinal imaging.
Principal investigator: Caroline Lind
Internal members: Therese von Hanno, Liv-Hege Johnsen, Torgil Vangberg, Maria Carlsson, Ellisiv B Mathiesen
External collaborators: Tunde Peto (Ophthalmic Reading Centre, Queen´s University, Belfast, Northern Ireland), Alexander K. Schuster (Johannes Gutenberg University, Mainz, Germany)
Diabetic retinopathy - see the future in the eye
The aim of this innovation project is to reorganize and establish effective decentralized retinal screening of all patients with diabetes in Northern Norway. We combine grading of retinal photograpy by artificial intelligence (AI) and the clinically validated RetinaRisk algorithm with a more automated pateint adminsitrative system. Decentralized retinal imaging aimed at tailoring indidivualized follow-up and treatment will save time and cost while ensuring high qulity follow-up of patients with diabetes. The study group consists of clinical and technological expertice from North Norwegian hospitals, the Northern Norway regional health authority ICT trust (HN-IKT), the electronic health record DIPS® and the industry partners from RetinaRisk.
Principal investigator: Therese von Hanno
External collabortors: Gunn Hege Valøy (Nordland Hospital Trust), Geir Bertelsen (UiT), Maja Erke (Dept. of Ophthalmology, Oslo University Hospital and the Norwegian Directorate of e-health, ), Arpad Totth, Ægir Þór Steinarsson (RetinaRisk), Bjørn Fjukstad (DIPS AS), Are Edvardsen (HN-IKT), Jostein Stemland (Nordland Hospital Trust), Paul Daljord (user respresentative)
SENSE-Cog
SENSE-Cog is a European wide project focused on understanding the impact of dementia, age-related hearing and vision impairment. By using a multidisciplinary collaborative approach, Sense-Cog aims to address this negative impact and to promote mental well-being by understanding the inter-relationship of sensory impairments and cognitive and mental health function, identifying novel means of screening and detection for diagnostic and therapeutic purposes, and translating this knowledge into clinical applications to improve the mental well-being of EU citizens.
Principal investigator: Iracema Leroi (Trinity College Dublin, Ireland)
Local Principal investigator: Therese von Hanno
European Eye Epidemiology (E3)
The E3 consortium is a collaboration of over 30 eye studies in Europe that aims to advance research on eye conditions with a focus on collaboration and data sharing to promote eye-related research in a variety of areas. E3 works to harmonize methods for eye research and data collection to advance research on eye diseases with regard to pathophysiological mechanisms and risk factors including lifestyle, vascular and metabolic factors, genetics, epigenetics, and biomarkers, as well as to develop and validate prediction models for eye diseases.
Local Principal investigator: Geir Bertelsen
Publications
Northern Norway Health Region innovation (HNI0039-23) and research funds (HNF1655-23)