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Rinaldo, Christine Hanssen

Professor II
Institutt for klinisk medisin

Stillingsbeskrivelse:

Forskning, undervisning og veiledning i virologi




Forskningsinteresser

Humane polyomavirus (HPyV)

Hepatitt E-virus (HEV)

Arbeider i CRIStin


  • Olsøy, Irene Beate; Henriksen, Stian; Weissbach, Fabian H.; Larsen, Marthe; Borgen, Karoline; Abravanel, Florence; Kamar, Nassim; Paulssen, Eyvind Jakob; Hirsch, Hans H.; Rinaldo, Christine Hanssen. Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: the Tromsø study. Medical Microbiology and Immmunology 2019. ISSN 0300-8584.s doi: 10.1007/s00430-019-00599-5.

  • Cesaro, Simone; Dalianis, Tina; Rinaldo, Christine Hanssen; Koskenvuo, Minna; Pegoraro, Anna; Einsele, Hermann; Cordonnier, Catherine; Hirsch, Hans H.. ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients. Journal of Antimicrobial Chemotherapy 2018; Volum 73 (1). ISSN 0305-7453.s 12 - 21.s doi: 10.1093/jac/dkx324.

  • Alstadhaug, Karl Bjørnar; Myhr, Kjell-Morten; Rinaldo, Christine Hanssen. Progredierende multifokal leukoencefalopati. Tidsskrift for Den norske legeforening 2017. ISSN 0029-2001.s doi: 10.4045/tidsskr.16.1092.

  • Papadimitriou, John C.; Randhawa, Parmjeet Singh; Rinaldo, Christine Hanssen; Drachenberg, Cinithia B.; Alexiev, Borislav A.; Hirsch, H. H.. BK polyomavirus infection and renourinary tumorigenesis. American Journal of Transplantation 2016; Volum 16 (2). ISSN 1600-6135.s 398 - 406.s doi: 10.1111/ajt.13550.

  • Henriksen, Stian; Mittelholzer, Christian; Gosert, Rainer; Hirsch, Hans H; Rinaldo, Christine Hanssen. Human BK polyomavirus plasmid pBKV (34-2) (Dunlop) contains mutations not found in the originally published sequences. Microbiology Resource Announcements (MRA) 2016; Volum 3 (2). ISSN 2169-8287.s doi: 10.1128/genomeA.00046-15.

  • Henriksen, Stian; Hansen, Terkel; Bruun, Jack-Ansgar; Rinaldo, Christine Hanssen. The Presumed Polyomavirus Viroporin VP4 of Simian Virus 40 or Human BK Polyomavirus Is Not Required for Viral Progeny Release. Journal of Virology 2016; Volum 90 (22). ISSN 0022-538X.s 10398 - 10413.s doi: 10.1128/JVI.01326-16.

  • Tylden, Garth Daryl; Hirsch, Hans H.; Rinaldo, Christine Hanssen. Brincidofovir (CMX001) inhibits BK polyomavirus replication in primary human urothelial cells. Antimicrobial Agents and Chemotherapy 2015; Volum 59 (6). ISSN 0066-4804.s 3306 - 3316.s doi: 10.1128/AAC.00238-15.

  • Sharma, Biswa Nath; Marschall, Manfred; Henriksen, Stian; Rinaldo, Christine H. Antiviral effects of artesunate on polyomavirus BK replication in primary human kidney cells. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (1). ISSN 0066-4804.s 279 - 289.s doi: 10.1128/AAC.01800-13.

  • Hirsch, HH; Babel, N; Comoli, P; Friman, V; Ginevri, F; Jardine, AG; Lautenschlager, I; Legendre, Christophe M.; Midtvedt, Karsten; Munoz, P; Randhawa, P; Rinaldo, Christine Hanssen; Wieszek, A. European perspective on human polyomavirus infection, replication and disease in solid organ transplantation.. Clinical Microbiology and Infection 2014; Volum 20. ISSN 1198-743X.s 74 - 88.s doi: 10.1111/1469-0691.12538.

  • Sharma, Biswa Nath; Marschall, Manfred; Rinaldo, Christine Hanssen. Antiviral effects of artesunate on JC polyomavirus replication in COS-7 Cells. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (11). ISSN 0066-4804.s 6724 - 6734.s doi: 10.1128/AAC.03714-14.

  • Alstadhaug, Karl Bjørnar; Croughs, Thérèse; Henriksen, Stian; Leboeuf, Céline; Sereti, Irini; Hirsch, Hans H.; Rinaldo, Christine Hanssen. Treatment of progressive multifocal leukoencephalopathy with interleukin 7. JAMA Neurology 2014; Volum 71 (8). ISSN 2168-6149.s 1030 - 1035.s doi: 10.1001/jamaneurol.2014.825.

  • Henriksen, Stian; Tylden, Garth Daryl; Dumoulin, Alexis; Nath, Sharma Biswa; Hirsch, Hans H.; Rinaldo, Christine Hanssen. The human fetal glial cell line SVG p12 contains infectious BK polyomavirus. Journal of Virology 2014; Volum 88 (13). ISSN 0022-538X.s 7556 - 7568.s doi: 10.1128/JVI.00696-14.

  • Simon-Santamaria, Jaione; Rinaldo, Christine Hanssen; Kardas, Piotr; Li, Ruomei; Malovic, Ivana; Elvevold, kjetil helge; McCourt, Peter Anthony; Smedsrød, Bård; Hirsch, Hans H.; Sørensen, Karen Kristine. Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta. PLOS ONE 2014; Volum 9 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0111762.

  • Li, Ruomei; Sharma, Biswa Nath; Linder, Stig; Gutteberg, Tore Jarl; Hirsch, Hans H.; Rinaldo, Christine H. Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology 2013; Volum 440 (1). ISSN 0042-6822.s 41 - 50.s doi: 10.1016/j.virol.2013.01.024.

  • Rinaldo, Christine H; Tylden, Garth Daryl; Sharma, Biswa Nath. The human polyomavirus BK (BKPyV): virological background and clinical implications. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2013; Volum 121 (8). ISSN 0903-4641.s 728 - 745.s doi: 10.1111/apm.12134.

  • Gosert, Rainer; Rinaldo, Christine H; Wernli, Marion; Major, Eugene O.; Hirsch, Hans H.. CMX001 (1-O-Hexadecyloxypropyl-Cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-Derived Astrocytes. Antimicrobial Agents and Chemotherapy 2011; Volum 55 (5). ISSN 0066-4804.s 2129 - 2136.s doi: 10.1128/AAC.00046-11.

  • Sharma, Biswa Nath; Li, Ruomei; Bernhoff, Eva; Gutteberg, Tore Jarl; Rinaldo, Christine H. Fluoroquinolones inhibit human polyomavirus BK (BKV) replication in primary human kidney cells. Antiviral Research 2011; Volum 92 (1). ISSN 0166-3542.s 115 - 123.s doi: 10.1016/j.antiviral.2011.07.012.

  • Beckmann, Christiane; Dumoulin, Alexis; Rinaldo, Christine H; Hirsch, Hans H.. Comparison of a UL111a Real-time PCR and pp65 Antigenemia for the Detection of Cytomegalovirus. Journal of Medical Virology 2011; Volum 83 (12). ISSN 0146-6615.s 2143 - 2150.s doi: 10.1002/jmv.22232.

  • Myhre, Marit Renee; Olsen, Gunn-Hege; Gosert, Rainer; Hirsch, Hans H.; Rinaldo, Christine H. Clinical polyomavirus BK variants with agnogene deletion are non-functional but rescued by trans-complementation. Virology 2010; Volum 398 (1). ISSN 0042-6822.s 12 - 20.s doi: 10.1016/j.virol.2009.11.029.

  • Unterstab, Gunhild; Gosert, Rainer; Leuenberger, David; Lorentz, Pascal; Rinaldo, Christine H; Hirsch, Hans H.. The polyomavirus BK agnoprotein co-localizes with lipid droplets. Virology 2010; Volum 399 (2). ISSN 0042-6822.s 322 - 331.s doi: 10.1016/j.virol.2010.01.011.

  • Rinaldo, Christine H; Gosert, Rainer; Bernhoff, Eva; Finstad, Solrun; Hirsch, Hans H.. 1-O-Hexadecyloxypropyl Cidofovir (CMX001) Effectively Inhibits Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial Cells. Antimicrobial Agents and Chemotherapy 2010; Volum 54 (11). ISSN 0066-4804.s 4714 - 4722.s doi: 10.1128/AAC.00974-10.

  • Næss, Halvor; Glad, Solveig B; Storstein, Anette; Rinaldo, Christine H; Mørk, Sverre; Myhr, Kjell-Morten; Hirsch, Hans. Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report. BMC Neurology 2010; Volum 10. ISSN 1471-2377.s doi: 10.1186/1471-2377-10-32.

  • Bernhoff, Eva; Tylden, Garth Daryl; Kjerpeseth, Lars Jøran; Gutteberg, Tore Jarl; Hirsch, Hans H.; Rinaldo, Christine H. Leflunomide Inhibition of BK Virus Replication in Renal Tubular Epithelial Cells. Journal of Virology 2010; Volum 84 (4). ISSN 0022-538X.s 2150 - 2156.s doi: 10.1128/JVI.01737-09.

  • Furnes, Clemens; Kileng, Øyvind; Rinaldo, Christine Hanssen; Seppola, Marit; Jensen, Ingvill; Robertsen, Børre. Atlantic cod (Gadus morhua L.) possesses three homologues of ISG15 with different expression kinetics and conjugation properties. Developmental and Comparative Immunology 2009; Volum 33 (12). ISSN 0145-305X.s 1239 - 1246.s doi: 10.1016/j.dci.2009.07.005.

  • Olsen, gunn-hege; Hirsch, Hans H.; Rinaldo, christine h. Functional Analysis of Polyomavirus BK Non-Coding Control Region Quasispecies From Kidney Transplant Recipients. Journal of Medical Virology 2009; Volum 81 (11). ISSN 0146-6615.s 1959 - 1967.s doi: 10.1002/jmv.21605.

  • Bernhoff, Eva; Gutteberg, tore jarl; Sandvik, Kjersti; Hirsch, Hans H.; Rinaldo, christine h. Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. American Journal of Transplantation 2008; Volum 8. ISSN 1600-6135.s 1413 - 1422.s doi: 10.1111/j.1600-6143.2008.02269.x.

  • Grinde, Bjørn; Gayorfar, Marc; Rinaldo, Christine H.. Impact of a polyomavirus (BKV) infection on mRNA expression in human endothelial cells. Virus Research 2007; Volum 123. ISSN 0168-1702.s 86 - 94.s doi: 10.1016/j.virusres.2006.08.005.

  • Olsen, Gunn-Hege; Per Arne, Andresen; Hilmarsen, Hilde Tveitan; Bjørang, Ola; Scott, Helge; Midtvedt, Karsten; Rinaldo, Christine H. Genetic variability in BK virus regulatory regions in urine and kidney biopsies from renal-transplant patients. Journal of Medical Virology 2006. ISSN 0146-6615.

  • Rinaldo, Christine H; Hansen, Hilde; Traavik, Terje I. Human endothelial cells allow passage of an archetypal BK virus (BKV) strain - a tool for cultivation and functional studies of natural BKV strains. Archives of Virology 2005; Volum 150. ISSN 0304-8608.s 1449 - 1458.

  • Jul-Larsen, Åsne; Jul-Larsen, A; Visted, T; Karlsen, BO; Rinaldo, Christine H; Bjerkvig, R; Lonning, PE; Lønning, Per Eystein; Boe, SO; Bøe, Stig Ove. PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication. Experimental Cell Research 2004; Volum 298. ISSN 0014-4827.s 58 - 73.

  • Rinaldo, christine h; Myhre, marit renee; Alstad, Hilde; Nilsen, Ø; Traavik, Terje. BK virus transiently transforms and persistenly infects cultured human osteosarcoma cells. Virus Research 2003; Volum 93. ISSN 0168-1702.s 181 - 187.

  • Sanchez Romano, Javier; Larsen, Anett Kristin; Elvevold, kjetil helge; Holte, Christopher Florian; Simon-Santamaria, Jaione; Hirsch, Hans H.; Rinaldo, Christine Hanssen; McCourt, Peter Anthony; Sørensen, Karen Kristine; Smedsrød, Bård. SECVIR - The role of scavenger endothelial cells in elimination of virus. The 3rd Annual IBA Meeting 2019-11-04 - 2019-11-05 2019.

  • Rinaldo, Christine Hanssen; Henriksen, Stian; Tylden, Garth Daryl; Hirsch, Hans H.. Reply to "contamination of SVG p12 cells with BK polyomavirus occurred after deposit in the American type culture collection". Journal of Virology 2014; Volum 88 (21). ISSN 0022-538X.s 12930 - 12930.s doi: 10.1128/JVI.02153-14.

  • Alstadhaug, Karl Bjørnar; Croughs, Therese; Henriksen, Stian; Sereti, Irini; Hirsch, Hans H.; Rinaldo, Christine Hanssen. A patient with idiopathic CD4+ T-cell lymphocytopenia and progressiv mulitifocal leukoencephalopathy: treatment by recombinant interleukin-7 and characterization of polyomavirus JC. 24 th Annual Meeting of the Society for Virology 2014-03-26 - 2014-03-29 2014.

  • Simon-Santamaria, Jaione; Rinaldo, Christine H; Kardas, Piotr; Li, Ruomei; Malovic, Ivana; Elvevold, Kjetil H.; McCourt, Peter Anthony; Smedsrød, Bård; Hirsch, Hans H.; Sørensen, Karen Kristine. Role of scavenger endothelial cells in polyomavirus JC and BK clearance. Keystone Symposia on Molecular and Cellular Biology - J6: Innate Immunity to Viral Infections 2014-01-19 - 2014-01-24 2014.

  • Rinaldo, Christine H; Sharma, Biswa Nath; Manfred, Marschall; Henriksen, Stian; Gutteberg, Tore Jarl. Effects of Artesunate on Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial Cells. 23rd Annual Meeting of the Society for Virology 2013-03-06 - 2013-03-09 2013.

  • Rinaldo, Christine H; Hirsch, Hans H.. The human polyomaviruses: from orphans and mutants to patchwork family. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2013; Volum 121 (8). ISSN 0903-4641.s 681 - 684.s doi: 10.1111/apm.12125.

  • Sharma, Biswa Nath; Marschall, Manfred; Henriksen, Stian; Gutteberg, Tore Jarl; Rinaldo, Christine H. Antiviral effects of artesunate on polyomavirus BK replication in primary human renal tubular epithelial cells. Journal of Neurovirology 2013; Volum 19 (3). ISSN 1355-0284.s 295 - 296.

  • Simon-Santamaria, Jaione; Li, Ruomei; Kardas, Piotr; Malovic, Ivana; Elvevold, Kjetil H.; McCourt, Peter Anthony; Smedsrød, Bård; Hirsch, Hans; Rinaldo, Christine H; Sørensen, Karen Kristine. Role of liver sinusoidal endothelial cells in blood clearance of polyomavirus BK and JC. 4th PhD Conference in Medical Imaging 2012-11-28 - 2012-11-29 2012.

  • Rinaldo, Christine Hanssen; Li, Ruomei; Sharma, Biswa Nath; Linder, Stig; Gutteberg, Tore Jarl; Hirsch, Hans H.. Polyomavirus BK (BKV) replication in human urothelial cells - role in polyomavirus associated hemorrhagic cystitis and nephropathy. 22nd Annual Meeting of the Society for Virology 2012-03-14 - 2012-03-17 2012.

  • Sharma, Biswa Nath; Marschall, Manfred; Henriksen, Stian; Gutteberg, Tore Jarl; Rinaldo, Christine Hanssen. Antiviral Effects of Artesunate on Polyomavirus BK Replication in Primary Human Kidney Cells. 2nd Antiviral congress 2012-11-11 - 2012-11-13 2012.

  • Hirsch, Hans H.; Beckmann, Christiane; Dumoulin, Alexis; Dørmenen, Enid; Bauer, Christine; Rinaldo, Christine Hanssen. Cytomegalovirus and Epstein-Barr Virus PCR quantification: impact of sample matrix and extraction methods in a two-centers comparative study and implementation of the first WHO International Standard for Cytomegalovirus. Swiss Microbiology Annual Congress 2012-06-21 - 2012-06-22 2012.

  • Rinaldo, Christine H; Li, Ruomei; Sharma, Biswa Nath; Linder, Stig; Gutteberg, Tore Jarl; Hirsch, Hans H.. Polyomavirus BK (BKV) Replication in Human Urothelial Cells Role in Polyomavirus-Associated Nephropathy and Hemorrhagic Cystitis. American Journal of Transplantation 2012; Volum 12. ISSN 1600-6135.s 348 - 348.

  • Rinaldo, christine h; Bernhoff, E; Tylden, G; Kjerpeseth, LJ; Gutteberg, TJ; Hirsch, HH. Leflunomide Interferes with BK Virus by Disrupting the Viral Nuclear Replication Architecture in Renal Tubular Cells. American Journal of Transplantation 2009; Volum 9. ISSN 1600-6135.s 335 - 336.

  • Bernhoff, Eva; Tylden, Garth Daryl; Kjerpeseth, LJ; Gutteberg, tore jarl; Hirsch, HH; Rinaldo, christine h. Leflunomide inhibits BK virus replication but simultaneously compromises renal tubular epithelial cell proliferation. Journal of Clinical Virology 2009; Volum 46. ISSN 1386-6532.s S56 - S56.

  • Rinaldo, christine h; Bernhoff, E; Tylden, G; Sandvik, K; Hirsch, HH; Gutteberg, tore jarl. Time-dependent effect of cidofovir and leflunomide on polyomavirus BK replication and kidney cell viability. American Journal of Transplantation 2008; Volum 8. ISSN 1600-6135.s 462 - 463.

  • Gutteberg, tore jarl; Rinaldo, christine h. Lactoferrin confidential: ancient actor starring in new role?. Transplant Infectious Disease 2008; Volum 10. ISSN 1398-2273.s 77 - 79.

  • Grinde, Bjørn; Rinaldo, christine h. Effect of three viruses and interferon on gene expression. Journal of Clinical Virology 2006; Volum 36. ISSN 1386-6532.s S15 - S15.