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Lars Småbrekke

Førsteamanuensis. Samfunnsfarmasi.
Klinisk farmasi og farmakoepidemiologi, forskningsgruppe

Stillingsbeskrivelse:

Stillingen er tillagt ansvar for emnene Far-2101 og Far-3101, og jeg deltar i tillegg i annen undervisning for farmasistudenter i emnene Far-1101, Far-3002 og Far-3111. Jeg underviser dessuten på Hel-0700 og diverse masterkurs og PhD kurs.

Forskningen er rettet mot ulike aspekter på legemiddelbruk, først og fremst om antibiotika, og er i hovedsak basert på data fra befolkningsstudier, Reseptregisteret og data samlet fra klinisk praksis i sykehus.




Forskningsinteresser

Legemiddelbruk på individ- og populasjonsnivå, med hovedfokus på antibiotikabruk.

CV

Lars Småbrekke

Birth date     18.1.1959

 

Education

1985                Candidatus pharmaciae, University of Oslo (UiO)

1999               Master of Public Health, University of Tromsø (UiT)

2009               PhD. UiT

 

Work experience

1986-98         Hospital pharmacy.

1998-2008     Regional Drug Information Centre of North Norway.

2008-09         PhD student.

2009-              UiT. Associate professor. IPSUM Research group.

 

Relevant commotions

1999-2000     Board member. National Board of Pharmacovigilance

2008-2012     Board member. National Board of Reimbursement

2010-              Board member. Norwegian Society of Pharmacoepidemiology

2016-              Board member. Regional Health Authority

 

Research and development (International journals)

Rygnestad T, Småbrekke L, Nesje L, Talsethagen H, Rogne P, Myhr K, Bentzen, I. Impact of improved treatment of Sexually Transmitted disease on HIV infection. Lancet 1995; 346 (8983): 1157.

Småbrekke L, Braathen P. Drugs with lactose in patients with lactose intolerance? Tidsskr Nor Medical Association 2000; 120 (19): 2303-4.

Småbrekke L. Large differences in the consumption profile of antibiotics at two university hospitals in Norway. Nor J Epidemiol 2001; 11 (1): 61-5.

Småbrekke L, Berild D, Giaever A, et al. Educational Intervention for Parents and Health Care providers Leads to Reduced Antibiotic Use in Otitis Media. Scand J Infect Dis 2002; 34 (9): 657-9.

Simonsen GS, Småbrekke L, Monnet DL, Sørensen TL et al. Prevalence of resistance two ampicillin, gentamicin and vancomycin in Enterococcus faecalis and E. faecium from clinical specimens and use of antimicrobials in five Nordic hospitals. J Antimicrob Chemother 2003: 51 (2): 323-31.

Berild D, Småbrekke L, Halvorsen DS et al. Clostridium difficile Infections related to antibiotic use and infection control facilities in two university hospitals. J Hosp Infect 2003; 54 (3): 202-6.

Klingenberg C, Småbrekke L, Lier T, Flægstad T. Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis 2004; 36 (6-7): 474-9.

Raknes G, Småbrekke L. Echinacea spp and upper respiratory tract infections. Tidsskr Nor Medical Association 2006; 126: 2526-7.

Småbrekke L, Melbye H. Pharmacological treatment of acute cough. Tidsskr Nor Medical Association 2009:129 (10): 998-9.

Klingenberg C, Småbrekke L, Døllner H, Simonsen GS. Oral antibiotic treatment of urinary tract infection in children. Tidsskr Nor Medical Association 2009; 129 (13): 1342-4.

Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed two lamotrigine in breast milk. Ann Pharmacother 2009; 43 (11): 1893-7

Garcia BH, Småbrekke L, Trovik T, Giverhaug T. Application of the MAT-CHDSP two assess guideline adherence in prevention of coronary heart disease after percutaneous coronary intervention. Eur J Clin Pharmacol 2013; 69 (3): 703-9.

Utnes J, Småbrekke L, Garcia BH. MAT-CAP: a novel medication assessment tool to explore adherence two clinical practice guidelines in community acquired pneumonia. Pharmacoepidemiol Drug Saf 2014 Sep;23 (9): 933-41.

Garcia BH, Trovik T, Giver Haug T, L Småbrekke. Pharmacist-led follow-up program after discharge from hospital to improve secondary prevention of coronary heart disease. Submitted.

Garcia BH, Storli LS, Småbrekke L. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences. BMC Research Notes.2014, 7:197. DOI: 10.1186/1756-0500-7-197

Zykov I, Sundsfjord A, Småbrekke L, Samuelsen Ø. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010-2011. Infectious diseases 2015. http://dx.doi.org/10.3109/23744235.2015.1087648.

Melis M, Biagi C, Nonino F, Buccellato E, Donati M, Småbrekke L, Vaccheri A, Motola D. Drug induced progressive multifocal leukoencephalopathy: A comprehensive analysis of the WHO adverse drug reaction database. CNS drugs 2015; 29: 879-91

Høgli JU, Garcia BH, Skjold F, Skogen V, Småbrekke L. An audit and feedback intervention study increased appropriate antibiotic prescribing at a Norwegian hospital. BMC Infect Dis 2016;16(1):96. doi: 10.1186/s12879-016-1426-1.

Antibiotics to outpatients in Norway – assessing effect of latitude and municipality population size using quantile regression. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)

Exploring antibiotic prescribing in Norway using multivariate analysis. Haugen P, Simonsen GS, Primicerio R, Furberg AS, Småbrekke L. Pharmaceutical Statistics 2016; (submitted)

Raknes G, Småbrekke L. The Norwegian Low Dose Naltrexone tsunami. Patient and prescriber characteristics, and dispense patterns. A cohort study. Pharmacoepidemiol Drug Saf 2016; doi: 10.1002/pds.4110.

Raknes G, Småbrekke L. Low Dose Naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiol Drug Saf 2017; DOI: 10.1002/pds.4201

 

Supervision of PhD students

Beate Garcia (Dissertation in 2012 – A thesis in clinical pharmacy)

June Utnes (Dissertation October 2015 – A thesis in clinical pharmacy)

Paul Haugen (Dissertation March 2015 – A thesis in pharmacoepidemiology)

Ilya Zykov (Project in microbiology)

Tomas Zimba (Project in microbiology)

 

Supervision of Master students

Approxemately 25 students in the pharmacy program in Norway, Malawi and Mozambique. Eight medical students (fifth year semester thesis).

 

Teaching

Bachelor-/Master level in epidemiology/pharmacoepidemiology. Also teaching at courses PhD courses in EPINOR

 

International projects

2013    NORHED. Antimicrobial stewardship and conservancy in Africa. For further information: http://www.norad.no/en/support/norhed/projects?index=30

Arbeider i CRIStin


  • Haugen, Pål; Simonsen, Gunnar Skov; Primicerio, Raul; Furberg, Anne-Sofie; Småbrekke, Lars. Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study.. Pharmaceutical statistics 2018; Volum 17 (1). ISSN 1539-1604.s 4 - 11.s doi: 10.1002/pst.1831.

  • Haldorsen, Bjørg; Giske, Christian G; Hansen, Dennis S; Helgason, Kristjan Orri; Kahlmeter, Gunnar; Löhr, Iren Høyland; Matuschek, Erika; Österblad, Monica; Rantakokko-Jalava, Kaisu; Wang, Mikala; Småbrekke, Lars; Samuelsen, Ørjan; Sundsfjord, Arnfinn. Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.. Journal of Antimicrobial Chemotherapy 2018; Volum 73 (10). ISSN 0305-7453.s 2738 - 2747.s doi: 10.1093/jac/dky276.

  • Raknes, Guttorm; Simonsen, Pia; Småbrekke, Lars. The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study. Journal of Crohn's and colitis 2018; Volum 12 (6). ISSN 1873-9946.s 677 - 686.s doi: 10.1093/ecco-jcc/jjy008.

  • Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels. Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model. Antimicrobial Agents and Chemotherapy 2018; Volum 62 (6). ISSN 0066-4804.s doi: 10.1128/AAC.02560-17.

  • Raknes, Guttorm; Småbrekke, Lars. Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database. Pharmacoepidemiology and Drug Safety 2017; Volum 26 (6). ISSN 1053-8569.s 685 - 693.s doi: 10.1002/pds.4201.

  • Raknes, Guttorm; Småbrekke, Lars. Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study. PLoS ONE 2017; Volum 12:e0187423 (11). ISSN 1932-6203.s 1 - 13.s doi: 10.1371/journal.pone.0187423.

  • Høgli, June Utnes; Garcia, Beate Hennie; Skjold, frode; Skogen, Vegard; Småbrekke, Lars. An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital. (fulltekst) (sammendrag) BMC Infectious Diseases 2016; Volum 16 (96). ISSN 1471-2334.s doi: 10.1186/s12879-016-1426-1.

  • Raknes, Guttorm; Småbrekke, Lars. A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study. Pharmacoepidemiology and Drug Safety 2016; Volum 26 (2). ISSN 1053-8569.s 136 - 142.s doi: 10.1002/pds.4110.

  • Zykov, Ilya Nikolaevich; Sundsfjord, Arnfinn; Småbrekke, Lars; Samuelsen, Ørjan. The antimicrobial activity of mecillinam, nitrofurantoin, temocillin and fosfomycin and comparative analysis of resistance patterns in a nationwide collection of ESBL-producing Escherichia coli in Norway 2010–2011. Infectious diseases 2015; Volum 48 (2). ISSN 2374-4243.s 99 - 107.s doi: 10.3109/23744235.2015.1087648.

  • Melis, Mauro; Biagi, Chiara; Småbrekke, Lars; Nonino, Francesco; Buccellato, Elena; Donati, Monia; Vaccheri, Alberto; Motola, Domenico. Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database. CNS Drugs 2015; Volum 29 (10). ISSN 1172-7047.s 879 - 891.s doi: 10.1007/s40263-015-0286-3.

  • Garcia, Beate Hennie; Giverhaug, Trude; Høgli, June U.; Skjold, Frode; Småbrekke, Lars. A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado]. Pharmacy Practice 2015; Volum 13 (2). ISSN 1885-642X.s 1 - 10.s doi: 10.18549/PharmPract.2015.02.575.

  • Garcia, Beate Hennie; Storli, Sissel Lisa; Småbrekke, Lars. A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences. BMC Research Notes 2014; Volum 7 (197). ISSN 1756-0500.s doi: 10.1186/1756-0500-7-197.

  • Høgli, June Utnes; Småbrekke, Lars; Garcia, Beate. MAT-CAP: A novel medication assessment tool to explore adherence to clinical practice guidelines in community-acquired pneumonia. Pharmacoepidemiology and Drug Safety 2014; Volum 23 (9). ISSN 1053-8569.s 933 - 941.s doi: 10.1002/pds.3640.

  • Garcia, Beate Hennie; Småbrekke, Lars; Trovik, Thor; Giverhaug, Trude. Application of the MAT-CHDSP to assess guideline adherence and therapy goal achievement in secondary prevention of coronary heart disease after percutaneous coronary intervention. European Journal of Clinical Pharmacology 2013; Volum 69 (3). ISSN 0031-6970.s 703 - 709.s doi: 10.1007/s00228-012-1402-7.

  • Nordmo, Elisabeth CY; Aronsen, lena; Wasland, K; SmÅbrekke, lars; Vorren, Solveig M.. Severe Apnea in an Infant Exposed to Lamotrigine in Breast Milk. The Annals of Pharmacotherapy 2009; Volum 43 (11). ISSN 1060-0280.s 1893 - 1897.s doi: 10.1345/aph.1M254.

  • SmÅbrekke, lars; Melbye, Hasse. Medikamentell behandling av akutt hoste. Tidsskrift for Den norske legeforening 2009; Volum 129 (10). ISSN 0029-2001.s 998 - 999.s doi: doi:10.4045/tidsskr.08.0438.

  • Klingenberg, Claus; SmÅbrekke, lars; Døllner, Henrik; Simonsen, Gunnar Skov. Peroral antibiotikabehandling av urinveisinfeksjon hos barn. (fulltekst) Tidsskrift for Den norske legeforening 2009 (129). ISSN 0029-2001.s 1342 - 1344.

  • Klingenberg, Claus; Småbrekke, Lars; Lier, T; Flægstad, Trond. Validation of a simplified netilmicin dosage regimen in infants. Scandinavian Journal of Infectious Diseases 2004; Volum 36. ISSN 0036-5548.s 474 - 479.

  • Svendsen, Kristian; Karlstad, Øystein; Småbrekke, Lars. Lower cancer incidence-warfarin effect or immortal time bias?. JAMA Internal Medicine 2018; Volum 178 (4). ISSN 2168-6106.s 585 - 585.s doi: 10.1001/jamainternmed.2018.0370..

  • Svendsen, Kristian; Karlstad, Øystein; Småbrekke, Lars. To the editor. JAMA Internal Medicine 2018; Volum 178 (4). ISSN 2168-6106.s 585 - 585.s doi: 10.1001/jamainternmed.2018.0370.

  • Stensen, Dina; Småbrekke, Lars; Olsen, Karina; Grimnes, Guri; Nielsen, Christopher Sivert; Simonsen, Gunnar Skov; Sollid, Johanna U Ericson; Furberg, Anne-Sofie. Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. The Tromsø Study Fit Futures 2.. Norsk forening for epidemiologi: NOFE conference 2017 2017-11-07 - 2017-11-08 2017.

  • Sørensen, Martin; Kuehn, Annette; Mills, E.N. Clare; Costello, Carol Ann; Ollert, Markus; Småbrekke, Lars; Primicerio, Raul; Wickman, Magnus; Klingenberg, Claus Andreas. Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial. Journal of Allergy and Clinical Immunology 2017; Volum 140 (4). ISSN 0091-6749.s 1170 - 1172.s doi: 10.1016/j.jaci.2017.03.043.

  • Svendsen, Kristian; Kongsgård, Håvard Wahl; Haugen, Pål; Småbrekke, Lars. Does travel time to pharmacies and general physicians influence the use of antibiotics in Norway?. 32nd International Conference of Pharmacoepidemiology (ICPE) 2016-08-25 - 2016-08-28 2016.

  • Engen, Tone Ruud; Garcia, Beate Hennie; Halvorsen, Kjell H.; Waaseth, Marit; Småbrekke, Lars; Ljones Wetting, Hilde. Er det trygt å velge billigere resept-medisiner?. (data) 2015.

  • Halvorsen, Kjell H.; Småbrekke, Lars; Granås, Anne Gerd. Use of drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) in older patients. International Journal of Clinical Pharmacology Research 2013; Volum 35 (6). ISSN 0251-1649.s 1337 - 1337.

  • Garcia, Beate Hennie; Giverhaug, Trude; Utnes, J.; Småbrekke, Lars. A follow-up program for patients with established coronary heart disease led by a clinical pharmacist: a randomized controlled trial. International Journal of Clinical Pharmacology Research 2013; Volum 35 (6). ISSN 0251-1649.s 1255 - 1256.

  • Høgli, June Utnes; Småbrekke, Lars; Garcia, Beate. A medication assessment tool for community acquired pneumonia (MAT-CAP): design and validation. International Journal of Clinical Pharmacology Research 2013; Volum 35 (6). ISSN 0251-1649.s 1349 - 1350.

  • Halvorsen, Kjell Hermann; Småbrekke, Lars; Granås, Anne Gerd. Legemidler mot ulcus og gastroøsofageal reflukssykdom (GERD) hos eldre pasienter. Farmasidagene 2013 2013-10-30 - 2013-11-01 2013.

  • Halvorsen, Kjell H.; Småbrekke, Lars; Granås, Anne Gerd. Use of drugs for opeptic ulcer and gastro-oesophageal reflux disease (GORD) in older patients. 42nd ESCP symposium on clinical pharamcy 2013-10-16 - 2013-10-18 2013.

  • Utnes, June; Småbrekke, Lars; Garcia, Beate Hennie. A Medication Assessment Tool for Community Acquired Pneumonia (MAT-CAP) - design and validation. Konferanse i klinisk farmasi 2013-10-16 - 2013-10-18 2013.

  • Garcia, Beate Hennie; Storli, Sissel Lisa; SmÅbrekke, lars. A qualitative study on patient experience with pharmacist follow-up. International Journal of Clinical Pharmacology Research 2011; Volum 33 (2). ISSN 0251-1649.s 324 - 325.

  • Nordmo, Elisabeth CY; Aronsen, lena; Wasland, K; SmÅbrekke, lars; Vorren, Solveig M.. Severe Apnoea in an Infant Exposed to Lamotrigine in Breast Milk. Drug Safety 2009; Volum 32 (10). ISSN 0114-5916.s 951 - 951.

  • Raknes, Guttorm; SmÅbrekke, lars. Echinacea spp. (solhatt) og øvre luftveisinfeksjon. Tidsskrift for Den norske legeforening 2006; Volum 126 (19). ISSN 0029-2001.s 2526 - 2527.

  • Roland, Pål-Didrik Hoff; Schjøtt, Jan; Småbrekke, Lars; Westergren, Tone. RELIS spørsmål og svar-database på Internett. Utposten 2001; Volum 30 (6). ISSN 0800-5680.s 38 - 39.