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Fabrizio Clarelli

Postdoktor
Computational Pharmacology, Research Group

Stillingsbeskrivelse:

Research Interests

Antibiotics, Reaction kinetics, Population biology, Tuberculosis, Mathematical modeling, Differential equations, Numerical schemes, Optimization methods.

Biographical data

Fabrizio Clarelli got a master degree in Physics at the University of Rome "La Sapienza", discussing a thesis: " Stability region of Neutron star and mass-radius relationship in general relativity " under the supervision of the Prof. Remo Ruffini. He got a Ph.D. in Applied Mathematics at the University of Rome "La Sapienza", with a thesis "Mathematical Modeling for Lung Infection", Supervisor Prof. Roberto Natalini. https://www.researchgate.net/publication/281088336_Mathematical_Modeling_for_lung_infections

He worked at the Laboratory of Biomathematics at the "Policlinico Gemelli" Hospital, Rome (Italy), "Istituto per le Applicazioni del Calcolo", IAC-CNR of Rome (Italy), Department of Mathematics of the University of L'Aquila and "Istituto per le Applicationi del Calcolo ", IAC-CNR of Rome and Florence (Italy).

He also has collaborations with:  Ted Cohen , Yale School of Public Health; Sören Abel, UiT University of Tromsø, Harvard Medical School & NCMM; Roberto Natalini,  Istituto per Application Calcolo IAC-CNR  Rome, Italy; Paolo Bison,  Institute for Construction Technology ITC-CNR , Padova, Italy; Angelo Vannozzi,  ENEA , Frascati, Italy; Massimiliano Di Cagno,  UiT University of Tromsø.   

Other publications

Book:   "Relatività Ristretta" (Special Relativity), Author: F. Clarelli, edited by Alpha Test, 2010. ISBN: 9788848312028.

Papers: 

  • "Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies"; P. Abel Zur Wiesch, F. Clarelli, T. Cohen. PLoS Comput Biol 13 (1): e1005321. https://doi.org/10.1371/journal.pcbi.1005321 
  • "Looking for central trends in the conformational freedom of proteins using NMR measurements"; F. Clarelli, L. Sgheri. Inverse Problems 2017; Volume 33 (2). ISSN 0266-5611.s doi: 10.1088 / 1361-6420 / aa54ea.
  • "Reconstructing or nonlinear heat transfer law from uncomplete boundary data", F. Clarelli, G. Inglese; Inverse Problems 32 (2016) 115017.
  • "A fluid dynamics multidimensional model or biofilm growth: stability, influence of environment and sensitivity", F. Clarelli, C. Di Russo, M. Ribot, R. Natalini; Mathematical Medicine and Biology,  doi: 10.1093 / imammb / dqv024 (2015). 

  • Pulsed Thermography for Depth Profiling in Marble Sulfation, P. Bison, F. Clarelli, A. Vannozzi,  Int J Thermophys  , 36: 1123-1130, (2015). 

  • "Thin plate approximation in active infrared thermography"; G. Inglese, F. Clarelli,  Inverse Problems in Science & Engineering,  Vol. 23, Issue 6, p.  1072-1084 (2015). 

  • "A mathematical model of copper corrosion"; F. Clarelli, B. De Filippo, R. Natalini; Applied Mathematical Modeling; Vol. 38, Issues 19-20, p.  4804-4816 (2014). 

  • "Detecting hidden defects from real data"; F. Clarelli, P, Bison, G. Inglese; Conference paper 12th International Conference on Quantitative Infrared Thermography, July (2014).
  • "A fluid dynamics model of the growth of phototrophic biofilms"; F. Clarelli, C. Di Russo, R. Natalini, M. Ribot; Journal of Mathematical Biology,  Vol. 66, Issue 7, pp. 1387-1408; 2013. 

  • "Mathematical Models for Copper Sulphation"; F. Clarelli, B. De Filippo, R. Natalini; 
European Research Consortium for Informatics and Mathematics (ERCIM) news  n.86, p.  50; 2011. 

  • "A pressure model of immune response to mycobacterium tuberculosis infection in several space dimensions"; F. Clarelli and R. Natalini.,  Mathematical Biosciences and  Engineering  , Vol. 7, N. 2, 277-300, (2010). doi: 10.3934 / mbe.2010.7.277. 

  • "Mathematical Models for Biofilms on the Surface of Monuments"; F. Clarelli, C. Di Russo, R. Natalini, M. Ribot; Applied and Industrial Mathematics in Italy III; Series on  Advances in Mathematics for Applied Sciences  : Volume 82, 2008. 

  • "Mathematics and monument conservation: free boundary models of marble sulfation"; F. Clarelli, A. Fasano, R: Natalini. SIAM J. Appl. Math  .: Vol. 69, No. 1, pp. 149-168; 2008. 

  • "A mathematical model for consolidation of building stones"; F. Clarelli, R. Natalini, C. Nitsch, ML Santarelli. Applied and Industrial Mathematics in Italy III; Series on  Advances in Mathematics for Applied Sciences  : Volume 82, 2008. 

  • "Mathematische modellen voor consolidatieprocessen in steen"; F. Clarelli, C. Giavarini, R. Natalini, C. Nitsch, ML Santarelli. Proceedings of "International Symposium: Stone Consolidation in Cultural Heritage - Research and Practice"  ; Lisbon, May 6-7, 2008. Editor: Laboratorio Nacional de Engenharia Civil. 

  • "Free-boundary models of sulfation"; F. Clarelli, A. Fasano, R. Natalini. PAMM Proc. Appl. Math. Mech. 7, 2007. 

  • "A mathematical model for the evolution of nitric oxide concentration in human breathing"; F. Clarelli, R. Gianni, R. Natalini. IAC Report n. 102  , 2007. 

  • "Mathematical Models for the Conservation of Cultural Heritage"; F. Clarelli, A. Fasano, R. Natalini. European Research Consortium for Informatics and Mathematics (ERCIM) news  , n. 71, Oct. 2007. 

  • "Neutron star mass-radius relationship and their stability region"; F. Clarelli and R. Ruffini.  European Physical Journal Plus "(ex Il Nuovo Cimento)  : Vol. 120 B, N. 10-11; 2005.
  • "Mathematical Modeling for Lung Infections"; F. Clarelli. PhD. Thesis  ; Dept. "Method of Modelli Matematici", University of Rome "La Sapienza". DOI: 10.13140 / RG.2.1.2594.4805 





Arbeider i CRIStin


  • Martinecz, Antal; Clarelli, Fabrizio; Abel, Sören; Abel zur Wiesch, Pia. Reaction Kinetic Models of Antibiotic Heteroresistance. International Journal of Molecular Sciences 2019. ISSN 1422-0067.s doi: 10.3390/ijms20163965.

  • Di Cagno, Massimiliano Pio; Clarelli, Fabrizio; Våbenø, Jon; Lesley, Christina; Rahman, Sokar Darsim; Cauzzo, Jennifer; Franceschinis, Erica; Realdon, Nicola; Stein, Paul C. Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements. Molecular Pharmaceutics 2018; Volum 15 (4). ISSN 1543-8384.s 1488 - 1494.s doi: 10.1021/acs.molpharmaceut.7b01053.

  • Clarelli, Fabrizio; Sgheri, Luca. Looking for central tendencies in the conformational freedom of proteins using NMR measurements. Inverse Problems 2017; Volum 33 (2). ISSN 0266-5611.s doi: 10.1088/1361-6420/aa54ea.

  • Abel zur Wiesch, Pia; Clarelli, Fabrizio; Cohen, Ted. Using chemical reaction kinetics to predict optimal antibiotic treatment strategies. PloS Computational Biology 2017; Volum 13:e1005321 (1). ISSN 1553-734X.s 1 - 28.s doi: 10.1371/journal.pcbi.1005321.

  • Clarelli, Fabrizio; Inglese, Gabriele. Reconstruction of a nonlinear heat transfer law from uncomplete boundary data by means of infrared thermography. Inverse Problems 2016; Volum 32 (11). ISSN 0266-5611.s doi: 10.1088/0266-5611/32/11/115017.

  • Clarelli, Fabrizio. Systems medicine approaches in infectious diseases. NCMM Molecular Medicine Research Course - PhD-level course 2018-10-12 - 2018-10-23 2018.

  • Clarelli, Fabrizio; Singh, Bhupender; Palmer, Adam; Abel, Sören; Cohen, Ted; Abel zur Wiesch, Pia. Quantitatively predicting antibiotic susceptibility from biochemical parameters: implications for antibiotic development and preventing resistance. 11th edition of the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2018-10-23 - 2018-10-23 2018.

  • Clarelli, Fabrizio; Singh, Bhupender; Cohen, Ted; Palmer, Adam; Chindelevitch, Leonid; Abel, Sören; Abel zur Wiesch, Pia. Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment. International Study Group for Systems Biology (ISGSB) Conference 2018-09-24 - 2018-09-28 2018.

  • Clarelli, Fabrizio; Cohen, Ted; Abel, Sören; Singh, Bhupender; Palmer, Adam; Chindelevitch, Leonid; Abel zur Wiesch, Pia. How molecular mechanisms of resistance affect resistance evolution. Challenges and new concepts in antibiotics research conference 2018-03-19 - 2018-03-21 2018.

  • Clarelli, Fabrizio; Chindelevitch, Leonid; Singh, Bhupender; Cohen, Ted; Abel, Sören; Abel zur Wiesch, Pia. Using models to understand how molecular mechanisms of resistance affect the risk of acquired drug resistance during treatment. Epidemics 6 Sixth International Conference on Infectious Disease Dynamics 2017-11-29 - 2017-12-01 2017.

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