Forskningsinteresser

- Massespektrometri

- Klinisk anvendt proteomikk

- System biologi

- Metabolomikk

- Kvantifisering av småmolekyler, herunder endogene og eksogene forbindelser, metabolitter, aminosyrer etc.

CV

Akademisk bakgrunn:

2012: : Førsteamanuensis ved Universitet i Tromsø, UiT

2011: Post. Doc. Leibniz–Institut für Analytische Wissenschaften – ISAS, Dortmund, Tyskland

2011: Førsteamanuensis ved Universitet i Tromsø, UiT - vikariat

2011: Philosophiae Doctor (PhD) i Farmasi ved Universitet i Tromsø, UiT

2007: Stipendiat i farmasi ved Universitet i Tromsø, UiT. Tittel på avhandling: “Antimicrobial and anticancer β-peptidomimetics - Synthesis and biological evaluation of a new class of highly potent compounds.”

2006: Vitenskapelig assistent

2006: Master i Farmasi, Universitet i Tromsø, UiT. Masteropgave med tittelen: “Syntese av lipofile β-aminosyrederivater for framstilling av biologisk aktive peptidomimetika"

Arbeider i CRIStin


  • Schniers, Armin; Pasing, Yvonne; Hansen, Terkel. Lys-C/Trypsin Tandem-Digestion Protocol for Gel-Free Proteomic Analysis of Colon Biopsies. Humana Press 2019 (1959) ISBN 9781493991631. ISSN 1064-3745.s 113 - 122.s doi: 10.1007/978-1-4939-9164-8.

  • Paulsen, Marianne Hagensen; Ausbacher, Dominik; Bayer, Annette; Engqvist, Magnus; Hansen, Terkel; Haug, Tor; Anderssen, Trude; Andersen, Jeanette hammer; Sollid, Johanna U Ericson; Strøm, Morten B.. Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry 2019; Volum 183. ISSN 0223-5234.s 111671 - 111682.s doi: 10.1016/j.ejmech.2019.111671.

  • Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Ahnlund, Maria; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro. Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state. Inflammatory Bowel Diseases 2019; Volum 25 (11). ISSN 1078-0998.s 1780 - 1787.s doi: 10.1093/ibd/izz098.

  • Schniers, Armin; Goll, Rasmus; Pasing, Yvonne; Sørbye, Sveinung; Florholmen, Jon; Hansen, Terkel. Ulcerative colitis: Functional analysis of the in-depth proteome. Clinical Proteomics 2019; Volum 16:4. ISSN 1542-6416.s 1 - 13.s doi: 10.1186/s12014-019-9224-6.

  • Pasing, Yvonne; Schniers, Armin; Hansen, Terkel. Straightforward Protocol for Gel-Free Proteomic Analysis of Adipose Tissue. Humana Press 2018 (1788) ISBN 9781493978540. ISSN 1064-3745.s 1 - 8.s doi: 10.1007/7651_2017_82.

  • Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Goll, Rasmus; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro. A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression. Inflammatory Bowel Diseases 2018; Volum 25 (3). ISSN 1078-0998.s 490 - 497.s doi: 10.1093/ibd/izy349.

  • Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. Journal of Cell Biology 2018; Volum 217 (10). ISSN 0021-9525.s 3640 - 3655.s doi: 10.1083/jcb.201711002.

  • Pasing, Yvonne; Colnoe, Sayda; Hansen, Terkel. Proteomics of hydrophobic samples: Fast, robust and low-cost workflows for clinical approaches. (fulltekst) Proteomics 2017; Volum 17 (6). ISSN 1615-9853.s doi: 10.1002/pmic.201500462.

  • Schniers, Armin; Anderssen, Endre; Fenton, Christopher Graham; Goll, Rasmus; Pasing, Yvonne; Paulssen, Ruth H; Florholmen, Jon; Hansen, Terkel. The Proteome of Ulcerative Colitis in Colon Biopsies from Adults - Optimized Sample Preparation and Comparison with Healthy Controls. PROTEOMICS - Clinical Applications 2017; Volum 11 (11-12). ISSN 1862-8346.s doi: 10.1002/prca.201700053.

  • Henriksen, Stian; Hansen, Terkel; Bruun, Jack-Ansgar; Rinaldo, Christine Hanssen. The Presumed Polyomavirus Viroporin VP4 of Simian Virus 40 or Human BK Polyomavirus Is Not Required for Viral Progeny Release. Journal of Virology 2016; Volum 90 (22). ISSN 0022-538X.s 10398 - 10413.s doi: 10.1128/JVI.01326-16.

  • Albert, Anastasia; Eksteen, Jacobus Johannes; Isaksson, Johan; Sengee, Myagmarsuren; Hansen, Terkel; Vasskog, Terje. General approach to determine disulfide connectivity in cysteine-rich peptides by sequential alkylation on solid phase and mass spectrometry. Analytical Chemistry 2016; Volum 88 (19). ISSN 0003-2700.s 9539 - 9546.s doi: 10.1021/acs.analchem.6b02115.

  • Stelzl, Dominik; Nielsen, Thorbjørn Terndrup; Hansen, Terkel; Di Cagno, Massimiliano Pio. β-CD-dextran polymer for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations. International Journal of Pharmaceutics 2015; Volum 496 (2). ISSN 0378-5173.s 896 - 902.s doi: 10.1016/j.ijpharm.2015.10.041.

  • Engesland, André; Skar, Merete L.; Hansen, Terkel; Skalko-Basnet, Natasa; Flaten, Gøril Eide. New Applications of Phospholipid Vesicle-Based Permeation Assay: Permeation Model Mimicking Skin Barrier. Journal of Pharmaceutical Sciences 2013; Volum 102 (5). ISSN 0022-3549.s 1588 - 1600.s doi: 10.1002/jps.23509.

  • Hansen, Terkel; Albers, Michel; Hedberg, Christian; Sickmann, Albert. Adenylylation, MS, and proteomics—Introducing a “new” modification to bottom-up proteomics. Proteomics 2013; Volum 13 (6). ISSN 1615-9853.s 955 - 963.s doi: 10.1002/pmic.201200344.

  • Hansen, Terkel; Moe, Morten Kaare; Anderssen, Trude; Strøm, Morten B.. Metabolism of small antimicrobial β2,2-amino acid derivatives by murine liver microsomes. European journal of drug metabolism and pharmacokinetics 2012; Volum 37 (3). ISSN 0378-7966.s 191 - 201.s doi: 10.1007/s13318-012-0086-9.

  • Hansen, Terkel; Ausbacher, Dominik; Zachariassen, Zack Georg; Anderssen, Trude; Havelkova, Martina; Strøm, Morten B.. Anticancer activity of small amphipathic β2,2-amino acid derivatives. European Journal of Medicinal Chemistry 2012; Volum 58. ISSN 0223-5234.s 22 - 29.s doi: 10.1016/j.ejmech.2012.09.048.

  • Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.

  • Tørfoss, Veronika; Ausbacher, Dominik; Cavalcanti Jacobsen, Cristiane de Albuquerque; Hansen, Terkel; Brandsdal, Bjørn Olav; Havelkova, Martina; Strøm, Morten B.. Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block. Journal of Peptide Science 2012; Volum 18 (3). ISSN 1075-2617.s 170 - 176.s doi: 10.1002/psc.1434.

  • Hansen, Terkel; Ausbacher, Dominik; Flaten, Gøril Eide; Havelkova, Martina; Strøm, Morten B.. Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration. Journal of Medicinal Chemistry 2011; Volum 54 (3). ISSN 0022-2623.s 858 - 868.s doi: 10.1021/jm101327d.

  • Hansen, Terkel; Alst, Tore; Havelkova, Martina; Strøm, Morten B.. Antimicrobial Activity of Small beta-Peptidomimeties Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides. Journal of Medicinal Chemistry 2010; Volum 53 (2). ISSN 0022-2623.s 595 - 606.s doi: 10.1021/jm901052r.

  • Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Jensen, Einar; Florholmen, Jon; Forsdahl, Guro. Metabolomics coupled with pathway analysis characterise metabolic changes in treatment-naive ulcerative colitis patients. European Crohn and Colitis Organization ECCO 2019 2019-03-07 - 2019-03-09 2019.

  • Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro. DOP15 Metabolomics coupled with pathway analysis characterise metabolic changes in treatment-naive ulcerative colitis patients. Journal of Crohn's and colitis 2019; Volum 13. ISSN 1873-9946.s doi: 10.1093/ecco-jcc/jjy222.050.

  • Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Ahnlund, Maria; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro. Lipidomics in ulcerative colitis reveal disruption of mucosal lipid composition associated with the disease state. American Journal of Gastroenterology 2019; Volum 114. ISSN 0002-9270.s doi: 10.14309/01.ajg.0000578136.97772.e2.

  • Diab, Joseph; Goll, Rasmus; Hansen, Terkel; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro. Lipidomics in Ulcerative Colitis Reveal Disruption of Mucosal Lipids Composition in Association with the Disease State. Advances in Inflammatory Bowel Disease 2018 2018-12-12 - 2018-12-15 2018.

  • Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Moritz, Thomas; Jensen, Einar; Goll, Rasmus; Florholmen, Jon; Forsdahl, Guro. A quantitative analysis of colonic mucosal oxylipins and endocannabinoids in Ulcerative Colitis patients and cytokines gene expression. Copenhagen Symposium On Separation Sciences 2018-06-26 - 2018-06-27 2018.

  • Diab, Joseph; Hansen, Terkel; Jensen, Einar; Vasskog, Terje; Goll, Rasmus; Florholmen, Jon; Forsdahl, Guro. Lipidomics and Metabolomics in Inflammatory Bowel Disease: From pathology to clinical development prediction. Norske Symposium i Kromatografi 2018-01-07 - 2018.

  • Diab, Joseph; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Thomas, Moritz; Goll, Rasmus; Florholmen, Jon; Forsdahl, Guro. Altered colonic mucosal oxylipins and endocannabinoids levels in treatment-naive and deep remission Ulcerative Colitis patients. Journal of Crohn's and colitis 2018; Volum 12. ISSN 1873-9946.s S092 - S093.s doi: 10.1093/ecco-jcc/jjx180.131.

  • Diab, Joseph; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Thomas, Moritz; Goll, Rasmus; Florholmen, Jon; Forsdahl, Guro. Altered colonic mucosal oxylipins and endocannabinoids levels in treatment-naive and deep remission Ulcerative Colitis patients. European Crohn and Colitis congress 18 2018-02-15 - 2018-02-17 2018.

  • Storflor, Merete; Schniers, Armin; Hansen, Terkel; Abel, Sören. Quantifying c-di-GMP during infections on a single cell level. ASM Conference on Vibrio2017: The Biology of Vibrios 2017-11-12 - 2017-11-15 2017.

  • Stelzl, Dominik; Nielsen, Thorbjørn Terndrup; Hansen, Terkel; Di Cagno, Massimiliano Pio. β-CD-dextran for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations. 2nd Annual Formulation & Drug Delivery Congress and Inhalation & Respiratory Drug Delivery Congress, 2016-05-18 - 2016-05-19 2016.

  • Engesland, André; Skar, Merete L.; Hansen, Terkel; Skalko-Basnet, Natasa; Flaten, Gøril Eide. Development of an artificial in vitro permeation skin model. 9th Central Symposium on Pharmaceutical Technology 2012-09-20 - 2012.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Hansen, Terkel; Ausbacher, Dominik; Havelkova, Martina; Strøm, Morten B.. Bactericidal activity of small β-peptidomimetics. European Peptide Symposium 2010-09-05 - 2010-09-09 2010.

  • Hansen, Terkel; Tore, Alst; Havelkova, Martina; Strøm, Morten B.. Antimicrobial activity of small β-peptidomimetics fulfilling the pharmacophore model of short cationic antimicrobial peptides. Norsk kjemisk vintermøte 2010-01-06 - 2010-01-10 2010.

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