Forskningsinteresser

 

1) Design, synthesis and development of antimicrobial and anticancer peptides and peptidomimetics as lead-compounds for drug-development and investigation of pharmacophore models.

2) Design and synthesis of peptidomimetics and bioactive scaffolds for optimization of potency and pharmacokinetic properties.

3) Isolation and structural elucidation of marine bioactive compounds from Arctic and sub-Arctic marine invertebrates and synthesis of marine natural product mimics (marine bio-prospecting).

 

Veiledning av PhD studenter

2000 – 2004: Biveileder for Dr. Morten K. Moe - Tittel på PhD avhandling: ESI low-energy tandem MS characterisation of lipids modified by a novel derivatisation method. Finansiert av Norges Forskningsråd.

2007 – 2010: Biveileder for Dr. Margey Tadesse - Tittel på PhD avhandling: Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. Finansiert av UiT.

2007 – 2011: Hovedveileder for Dr. Terkel Hansen (cand. pharm.) - Tittel på PhD avhandling: Antimicrobial and anticancer beta-peptidomimetics – synthesis and biological evaluation of a new class of small and highly potent compounds. Finansiert av UiT.

2008 – 2012: Hovedveileder for Dominik A. Ausbacher (cand. pharm.) - Tittel på PhD avhandling: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides - Investigations of antimicrobial and anticancer activity and the mechanisms of action. Finansiert av UiT.

2008 – 2013: Hovedveileder for Veronika Tørfoss (cand. pharm.) - Tittel på avhandling: Short anticancer peptides containing a lipophilic β2,2-amino acid - Synthesis and biological evaluation of linear and cyclic hepta-, hexa-, penta-, and tetrapeptides. Finansiert av Norges Forskningsråd (KOSK-II programmet).

2011 – 2015: Biveileder for Elisabeth Klungerbo Olsen (cand. pharm.) - Tittel på avhandling: Bioprospecting of Arctic marine organisms. Finansiert av MabCent – SFI.

2011 – pågående prosjekt: Hovedveileder for Elizaveta Mikhailovna Igumnova - Arbeidstittel: Chemical synthesis, isolation, and structural characterization of marine bioactive hit compounds. Finansiert av MabCent – SFI.

2011 – 2016: Biveileder for Runar Gjerp Solstad - Tittel på avhandling: Discovery of antimicrobial peptides in two invertebrates, the sea anemone Urticina eques and the sea urchin chinus esculentus - Isolation, characterization and structure-activity relationship studies. Finansiert av UiT.

2012 - 2017: Hovedveileder for Marianne Hagensen Paulsen - Tittel på avhandling: Synthetic mimics of antimicrobial peptides. Synthesis and biological studies of novel synthetic mimics of antimicrobial peptides. Finansiert av Norges Forskningsråd og UiT - "Fellesløftet".

2014 - 2017: Biveileder for Thomas Aleksander Bakka (NTNU - Trondheim) - Tittel på avhandling: Synthesis and antimicrobial evaluation of small molecule amphiphiles derived from amphiphilic antimicrobial natural products. Finansiert av NTNU.

2018 - pågående prosjekt: Biveileder for Manuel Karl Langer (Institutt for kjemi - IKJ, UiT) - Arbeidstittel: Synthesis of new antimicrobial, antibiofilm and antifouling agents. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger".

2018 - pågående prosjekt : Hovedveileder for Danijela Simonovic (Institutt for farmasi - IFA, UiT) - Arbeidstittel: Synthesis of antimicrobial amphipathic scaffolds targeting multi-resistant bacteria. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR.

2018 - pågående prosjekt: Biveileder for Christoffer Ågnes Sivertsen (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH UiT) - Arbeidstittel: Antibacterial and antibiofilm compounds in Arctic and sub-Arctic invertebrates. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.

2019 - pågående prosjekt: Biveileder for Susannah von Hofsten (Institutt for medisinsk biologi - IMB, UiT) - Arbeidstittel: Identifisering og utvikling av anticancer peptider og peptidomimetika for målrettet behandling av kreft. Finansiert av UiT - Norges arktiske universitet.

 

Veiledning av masterstudenter

Jeg har siden 2003 vært veileder for 28 mastergradsstudenter i farmasi / legemiddelkjemi / organisk kjemi.

 

CV

 

Akademisk bakgrunn:

1994: Bachelor / Cand. Mag. i kjemi (UiT).

1996: Master / Cand. Scient. i organisk kjemi (UiT). Tittel på mastergradsoppgave / hovedfagsoppgave: “Syntese av substratanaloger for collagenase ved peptidsyntese i løsning".

1996: Forsker ved Universitetssykehuset i Nord-Norge (UNN).

1997: PhD / doktorgradsstudent i organisk kjemi (UiT).

2001: Philosophiae Doctor (PhD) i organisk kjemi. Tittel på avhandling: “Lactoferricin as a model system for preparing highly active antimicrobial peptides”.

2001: Post doc.

2002 – 2012: Førsteamanuensis ved Institutt for farmasi (UiT).

2006: Universitetspedagogisk seminar (UPS) gjennomført.

2012: Professor ved Institutt for farmasi (UiT).

Undervisning

FAR-2301: Legemiddelkjemi og naturstoffkjemi

FAR-3301: Avansert farmasøytisk kjemi

Undervisning

FAR-2301: Legemiddelkjemi og naturstoffkjemi

FAR-3301: Avansert farmasøytisk kjemi

Arbeider i CRIStin


  • Paulsen, Marianne Hagensen; Ausbacher, Dominik; Bayer, Annette; Engqvist, Magnus; Hansen, Terkel; Haug, Tor; Anderssen, Trude; Andersen, Jeanette hammer; Sollid, Johanna U Ericson; Strøm, Morten B.. Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry 2019; Volum 183. ISSN 0223-5234.s 111671 - 111682.s doi: 10.1016/j.ejmech.2019.111671.

  • Paulsen, Marianne Hagensen; Karlsen, Eskil Andre; Ausbacher, Dominik; Anderssen, Trude; Bayer, Annette; Ochtrop, Philipp; Hedberg, Christian; Haug, Tor; Sollid, Johanna U Ericson; Strøm, Morten B.. An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science 2018; Volum 24 (10). ISSN 1075-2617.s 1 - 11.s doi: 10.1002/psc.3117.

  • Igumnova, Elizaveta; Mishchenko, Ekaterina; Haug, Tor; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Aarag, Elizabeth; Lauksund, Silje; Stensvåg, Klara; Strøm, Morten B.. Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.. Bioorganic & Medicinal Chemistry 2018; Volum 26 (17). ISSN 0968-0896.s 4930 - 4941.s doi: 10.1016/j.bmc.2018.08.032.

  • Bakka, Thomas Aleksander; Strøm, Morten B.; Andersen, Jeanette hammer; Gautun, Odd Reidar. Methyl propiolate and 3-butynone: starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation. Bioorganic & Medicinal Chemistry 2017; Volum 25 (20). ISSN 0968-0896.s 5380 - 5395.s doi: 10.1016/j.bmc.2017.07.060.

  • Bakka, Thomas Aleksander; Strøm, Morten B.; Andersen, Jeanette hammer; Gautun, Odd Reidar. Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles. Bioorganic & Medicinal Chemistry Letters 2017; Volum 27 (5). ISSN 0960-894X.s 1119 - 1123.s doi: 10.1016/j.bmcl.2017.01.092.

  • Hanski, Leena; Ausbacher, Dominik; Tiirola, Terttu; Strøm, Morten B.; Vuorela, Pia M.. Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia Pneumoniae. (fulltekst) (sammendrag) PLOS ONE 2016; Volum 11 (6). ISSN 1932-6203.s doi: 10.1371/journal.pone.0157306.

  • Igumnova, Elizaveta Mikhailovna; Mishchenko, Ekaterina; Haug, Tor; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Aarag, Elizabeth; Lauksund, Reidunn Silje; Stensvåg, Klara; Strøm, Morten B.. Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL–CARBA producing multi-resistant bacteria. Bioorganic & Medicinal Chemistry 2016; Volum 24 (22). ISSN 0968-0896.s 5884 - 5894.s doi: 10.1016/j.bmc.2016.09.046.

  • Paulsen, Marianne H.; Engqvist, Magnus; Ausbacher, Dominik; Strøm, Morten B.; Bayer, Annette. Efficient and scalable synthesis of α,α-disubstituted β-amino amides. Organic and biomolecular chemistry 2016; Volum 14 (31). ISSN 1477-0520.s 7570 - 7578.s doi: 10.1039/c6ob01219a.

  • Ausbacher, Dominik; Fallarero, Adyary; Kujala, Janni; Määttänen, Anni; Peltonen, Jouko; Strøm, Morten B.; Vuorela, Pia M.. Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling (Print) 2014; Volum 30 (1). ISSN 0892-7014.s 81 - 93.s doi: 10.1080/08927014.2013.847924.

  • Sivertsen, Annfrid; Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Anderssen, Trude; Brandsdal, Bjørn Olav; Havelkova, Martina; Skjørholm, Anne Elisabeth; Strøm, Morten B.. Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin. Journal of Peptide Science 2014; Volum 20 (4). ISSN 1075-2617.s 279 - 291.s doi: 10.1002/psc.2615.

  • Hansen, Terkel; Moe, Morten Kaare; Anderssen, Trude; Strøm, Morten B.. Metabolism of small antimicrobial β2,2-amino acid derivatives by murine liver microsomes. European journal of drug metabolism and pharmacokinetics 2012; Volum 37 (3). ISSN 0378-7966.s 191 - 201.s doi: 10.1007/s13318-012-0086-9.

  • Hansen, Terkel; Ausbacher, Dominik; Zachariassen, Zack Georg; Anderssen, Trude; Havelkova, Martina; Strøm, Morten B.. Anticancer activity of small amphipathic β2,2-amino acid derivatives. European Journal of Medicinal Chemistry 2012; Volum 58. ISSN 0223-5234.s 22 - 29.s doi: 10.1016/j.ejmech.2012.09.048.

  • Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Brandsdal, Bjørn Olav; Flaten, Gøril Eide; Anderssen, Trude; Cavalcanti Jacobsen, Cristiane de Albuquerque; Havelkova, Martina; Nguyen, Leonard T.; Vogel, Hans J.; Strøm, Morten B.. Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid. Journal of Peptide Science 2012; Volum 18 (10). ISSN 1075-2617.s 609 - 619.s doi: 10.1002/psc.2441.

  • Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.

  • Tørfoss, Veronika; Ausbacher, Dominik; Cavalcanti Jacobsen, Cristiane de Albuquerque; Hansen, Terkel; Brandsdal, Bjørn Olav; Havelkova, Martina; Strøm, Morten B.. Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block. Journal of Peptide Science 2012; Volum 18 (3). ISSN 1075-2617.s 170 - 176.s doi: 10.1002/psc.1434.

  • Hansen, Terkel; Ausbacher, Dominik; Flaten, Gøril Eide; Havelkova, Martina; Strøm, Morten B.. Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration. Journal of Medicinal Chemistry 2011; Volum 54 (3). ISSN 0022-2623.s 858 - 868.s doi: 10.1021/jm101327d.

  • Tadesse, Margey; Tabudravu, Jioji N.; Jaspars, Marcel; Strøm, Morten B.; Hansen, Espen; Andersen, Jeanette hammer; Kristiansen, Per Eugen; Haug, Tor. The antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E and F from the Arctic Bryozoan Tegella cf. spitzbergensis. Journal of natural products 2011; Volum 74. ISSN 0163-3864.s 837 - 841.s doi: 10.1021/np100499c.

  • Tadesse, Margey; Svenson, Johan; Jaspars, Marcel; Strøm, Morten B.; Abdelrahman, Mostafa H.; Andersen, Jeanette hammer; Hansen, Espen; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Synoxazolidinone C; a bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. Tetrahedron Letters 2011; Volum 52. ISSN 0040-4039.s 1804 - 1806.s doi: 10.1016/j.tetlet.2011.02.027.

  • Hansen, Terkel; Alst, Tore; Havelkova, Martina; Strøm, Morten B.. Antimicrobial Activity of Small beta-Peptidomimeties Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides. Journal of Medicinal Chemistry 2010; Volum 53 (2). ISSN 0022-2623.s 595 - 606.s doi: 10.1021/jm901052r.

  • Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tørfoss, Veronika; Andersen, Jeanette hammer; Hansen, Espen; Stensvåg, Klara; Haug, Tor. Synoxazolidinones A and B; novel bioactive alkaloids from the ascidian Synoicum pulmonaria. Organic Letters 2010; Volum 12 (21). ISSN 1523-7060.s 4752 - 4755.s doi: 10.1021/ol101707u.

  • Tadesse, Margey; Tørfoss, Veronika; Strøm, Morten B.; Hansen, Espen; Andersen, Jeanette hammer; Stensvåg, Klara; Haug, Tor. Isolation and biological activity of (E)-1-(4-hydroxystyryl)guanidine from the sub-Arctic ascidian, Dendrodoa aggregata. Biochemical Systematics and Ecology 2010; Volum 38 (4). ISSN 0305-1978.s 827 - 829.s doi: 10.1016/j.bse.2010.04.002.

  • Michelsen, Vibeke B; Moe, Grete; Strøm, Morten B.; Jensen, Einar; Lygre, Henning. Quantitative analysis of TEGDMA and HEMA eluted into saliva from two dental composites by use of GC/MS and tailor-made internal standards. Dental Materials 2008; Volum 24 (6). ISSN 0109-5641.s 724 - 731.s doi: 10.1016/j.denta1.2007.08.002.

  • Tadesse, Margey; Gulliksen, Bjørn; Strøm, Morten B.; Styrvold, Olaf B.; Haug, Tor. Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway. (fulltekst) Journal of Invertebrate Pathology 2008; Volum 99. ISSN 0022-2011.s 286 - 293.s doi: 10.1016/j.jip.2008.06.009.

  • Haug, Bengt Erik; Strøm, Morten B.; Svendsen, John Sigurd. The medicinal chemistry of short lactoferricin-based antibacterial peptides. Current Medicinal Chemistry 2007; Volum 14 (1). ISSN 0929-8673.s 1 - 18.

  • Moe, Morten Kaare; Anderssen, Trude; Strøm, Morten B.; Jensen, Einar. Total structure characterization of unsaturated acidic phospholipids provided by vicinal di-hydroxylation of fatty acid double bonds and negative electrospray ionization mass spectrometry. (data) Journal of the American Society for Mass Spectrometry 2005; Volum 16 (1). ISSN 1044-0305.s 46 - 59.s doi: 10.1016/j.jasms.2004.09.01.

  • Yang, Nannan; Strøm, Morten B.; Mekonnen, Seble Merid; Svendsen, John Sigurd; Rekdal, Øystein. The effects of shortening lactoferrin derived peptides against tumour cells, bacteria and normal human cells. Journal of Peptide Science 2004; Volum 10. ISSN 1075-2617.s 37 - 46.

  • Moe, Morten Kaare; Strøm, Morten B.; Jensen, Einar; Claeys, Magda. Negative electrospray ionization low-energy tandem mass spectrometry of hydroxylated fatty acids: a mechanistic study. Rapid Communications in Mass Spectrometry 2004; Volum 18. ISSN 0951-4198.s 1731 - 1740.s doi: 10.1002/rcm.1545.

  • Moe, Morten Kaare; Anderssen, Trude; Strøm, Morten B.; Jensen, Einar. Vicinal hydroxylation of unsaturated fatty acids for structural characterization of intact neutral phospholipids by negative electrospray ionization tandem quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry 2004; Volum 18. ISSN 0951-4198.s 2121 - 2130.s doi: 10.1002/rcm.1601.

  • Yang, Nannan; Strøm, Morten B.; Mekonnen, Seble Merid; Svendsen, John Sigurd; Rekdal, Øystein. The effect of shortening of lactoferrin derived peptides against tumor cells, bacteria and normal human cells. Journal of Peptide Science 2003; Volum 10. ISSN 1075-2617.s 37 - 46.

  • Strøm, Morten B.; Rekdal, Øystein; Svendsen, John Sigurd. Antimicrobial activity of short arginine- and tryptophan-rich peptides. Journal of Peptide Science 2002; Volum 8. ISSN 1075-2617.s 431 - 437.

  • Jing, WG; Strøm, Morten B.; Svendsen, John Sigurd; Vogel, Hans J.. Biophysical studies of the interaction of 15-residue lactoferricin B peptide analogs with model membranes. Biochemistry and Cell Biology 2002; Volum 80 (1). ISSN 0829-8211.s 161 - .

  • Lejon, Tore Sigvard; Strøm, Morten B.; Svendsen, John Sigurd. IS INFORMATION ABOUT PEPTIDE SEQUENCE NECESSARY IN MULTIVARIATE ANALYSIS. Chemometrics and Intelligent Laboratory Systems 2001; Volum 57. ISSN 0169-7439.s 93 - 95.

  • Valderhaug, Solveig; Lindberg, Daniel; Bakka, Thomas A; Strøm, Morten B.; Andersen, Jeanette hammer; Gautun, Odd Reidar. Synthesis and antimicrobial evaluation of fused benzene amphiphiles. Organisk kjemisk vintermøte OKV33 2018-01-11 - 2018-01-14 2018.

  • Bakka, Thomas Aleksander; Gautun, Odd Reidar; Strøm, Morten B.; Andersen, Jeanette hammer. Synthesis and antimicrobial evaluation of small amphipathic natural product mimics. Organisk kjemisk vintermøte 2017-01-12 - 2017-01-15 2017.

  • Bakka, Thomas A; Gautun, Odd Reidar; Strøm, Morten B.; Fiksdahl, Anne. Synthesis and Antimicrobial Evaluation of Small Molecule Amphiphiles Derived from Amphiphilic Antimicrobial Natural Products. 2017 (2017:239) ISBN 978-82-326-2551-2. ISSN 1503-8181.

  • Karlsen, Eskil André; Paulsen, Marianne H.; Haug, Tor; Strøm, Morten B.. Solid-phase peptide synthesis of antimicrobial peptide analogues of a marine peptide from Echinus esculentus and cyclic peptides with unnatural β2,2-amino acids incorporated. 2017.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Sollid, Johanna U Ericson; Blencke, Hans-Matti; Lauksund, Reidunn Silje; Haug, Tor; Aarag, Elizabeth; Strøm, Morten B.; Stensvåg, Klara. Antibacterial marine natural product mimics for treatment of infections.. The 8th International Conference on Marine Bioprospecting (BIOPROSP 2017) 2017-03-08 - 2017-03-10 2017.

  • Bakka, Thomas Aleksander; Gautun, Odd Reidar; Strøm, Morten B.; Andersen, Jeanette hammer. Synthesis of Amphipathic 1,2,3-Triazoles and Screening for Antimicrobial, Antibiofilm and Anti-oxidative Activities. 35th National medicinal chemistry symposium 2016-06-26 - 2016-06-29 2016.

  • Johansen, Cecilie; Strøm, Morten B.; Haug, Tor; Solstad, Runar Gjerp. Synthesis and structure-activity-studies of short antimicrobial peptides isolated from Echinus esculentus. 2016.

  • Solstad, Runar Gjerp; Haug, Tor; Stensvåg, Klara; Svenson, Johan; Strøm, Morten B.. Discovery of antimicrobial peptides in two marine invertebrates, the sea anemone Urticina eques and the sea urchin Echinus esculentus – Isolation, characterization, and structure-activity relationship studies.. 2016 ISBN 978-82-8266-128-7.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Blencke, Hans-Matti; Sollid, Johanna U Ericson; Aarag, Elizabeth; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antibacterial studies of compounds inspired by marine natural products. Cooperation programme in Fisheries and Marine Sciences 2016-04-27 - 2016-04-28 2016.

  • Ausbacher, Dominik; Lorenz, Lindsey A.; Goeres, Darla M.; Stewart, Philip S.; Strøm, Morten B.; Vuorela, Pia M.; Fallarero, Adyary. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. Annual DPhG meeting 2016-10-05 - 2016-10-07 2016.

  • Hanski, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production.. Conference on Lung and Respiratory Care 2016-08-01 - 2016-08-02 2016.

  • Solstad, Runar Gjerp; Blencke, Hans-Matti; Andreev, Yaroslav Alekseevich; Sydnes, Magne Olav; Moe, Morten Kaare; Johansen, Steinar Daae; Devold, hege; Strøm, Morten B.; Karp, Matti T.; Grishin, Eugene V.; Haug, Tor; Stensvåg, Klara. Bioactive peptides of Arctic marine invertebrates. The 7th International Conference on Marine Bioprospecting (BIOPROSP 2015) 2015-02-18 - 2015-02-20 2015.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Blencke, Hans-Matti; Aarag, Elizabeth; Sollid, Johanna U Ericson; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antimicrobial studies of Marine Natural Product Mimics (MNPMs). The 7th International Conference on Marine Bioprospecting (BIOPROSP 2015) 2015-02-18 - 2015-02-20 2015.

  • Ausbacher, Dominik; Hanski, Leena; Tiirola, Terttu; Strøm, Morten B.; Pia, Vuorela. Anti-Chlamydia pneumoniae activity of β2,2- amino acid derivatives mimicking antimicrobial peptides. Center for Drug Research Seminar 2014-09-04 - 2014-09-05 2014.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta Mikhailovna; Sollid, Johanna U Ericson; Aarag, Elizabeth; Blencke, Hans-Matti; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antimicrobial and anti-biofilm studies of Marine Natural Product Mimics. MabCent Science day 2014-11-25 - 2015-02-25 2014.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Blencke, Hans-Matti; Aarag, Elizabeth; Sollid, Johanna U Ericson; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. In vitro studies of the activities of marine natural product mimics on Stapylococcus epidermidis biofilms. The 4th International Symposium on Antimicrobial Peptides AMP 2014 2014-06-04 - 2014-06-06 2014.

  • Stensvåg, Klara; Blencke, Hans-Matti; Andreev, Yaroslav Alekseevich; Solstad, Runar Gjerp; Li, Chun; Sydnes, Magne Olav; Moe, Morten Kaare; Paulsen, Victoria; Johansen, Steinar Daae; Mishchenko, Ekaterina; Devold, hege; Bjørsvik, Magnus Støback; Strøm, Morten B.; Karp, Matti T.; Mahlapuu, Margit; Haug, Tor. Exploring the bioactive peptide space of arctic marine invertebrates. 4th international symposium on antimicrobial peptides 2014-06-04 - 2014-06-06 2014.

  • Fallarero, Adyary; Skogman, Malena; Moreira, Vânia; Manner, Suvi; Ausbacher, Dominik; Leino, Reko; Strøm, Morten B.; Yli-Kauhaluoma, Jari; Vuorela, Pia. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects 2013-09-09 - 2013-09-12 2013.

  • Tranung, Morten; Strøm, Morten B.; Haug, Tor; Paulsen, Marianne H.. Synthesis of short proline-rich cationic peptides based on the antimicrobial peptide Hyasin from the spider crab Hyas araneus. 2013.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Sollid, Johanna U. Ericson; Aarag, Elizabeth; Blencke, Hans-Matti; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antimicrobial biofilm studies of synthetic compounds inspired by marine natural compounds. 5th National PhD Conference in Medical Imaging 2013 2013-10-02 - 2013-10-03 2013.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Aarag, Elizabeth; Sollid, Johanna U. Ericson; Blencke, Hans-Matti; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antibacterial and anti-biofilm activity studies of synthetic compounds inspired by natural bioactive compounds. Seminar series in PhD school “Infection, Inflammation and Immunity” 2013-11-14 - 2013-11-14 2013.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Blencke, Hans-Matti; Sollid, Johanna U. Ericson; Aarag, Elizabeth; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara. Antibacterial and anti-biofilm studies of synthetic compounds derived from marine antimicrobial compounds. Bioprosp 2013 2013-02-20 - 2013-02-22 2013.

  • Solstad, Runar Gjerp; Blencke, Hans-Matti; Andreev, Yaroslav A.; Sydnes, Magne Olav; Moe, Morten Kaare; Johansen, Steinar Daae; Mishchenko, Ekaterina; Devold, Hege; Bjørsvik, Magnus S.; Strøm, Morten B.; Karp, Matti; Svenson, Johan; Grishin, Eugene V.; Haug, Tor; Stensvåg, Klara. Exploring the bioactive peptide space of arctic marine invertebrates. The 3rd International Meeting on Antimicrobial Peptides IMAP 2013 2013-09-23 - 2013-09-24 2013.

  • Mishchenko, Ekaterina; Igumnova, Elizaveta; Aarag, Elizabeth; Sollid, Johanna U. Ericson; Haug, Tor; Blencke, Hans-Matti; Strøm, Morten B.; Stensvåg, Klara. Antimicrobial and anti-biofilm activities of novel synthetic compounds based on marine bioactive molecules. The 3rd International Meeting on Antimicrobial Peptides IMAP 2013 2013-09-23 - 2013-09-24 2013.

  • Pohjala, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M.. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research 2012-07-01 - 2012-07-06 2012.

  • Ausbacher, Dominik; Kujala, Janni; Vuorela, Pia M.; Strøm, Morten B.; Fallarero, Adyary. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides 2012-06-13 - 2012-06-15 2012.

  • Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tabudravu, Jioji N.; Tørfoss, Veronika; Hansen, Espen; Andersen, Jeanette hammer; Abdelrahman, Mostafa H.; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Antimicrobial compounds from cold-water marine organisms. 2011 Norwegian Biochemical Society Contact Meeting 2011-02-03 - 2011-02-05 2011.

  • Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tørfoss, Veronika; Andersen, Jeanette hammer; Hansen, Espen; Stensvåg, Klara; Haug, Tor. Synoxazolidinones A and B; novel bioactive alkaloids from the ascidian Synoicum pulmonaria. ChemInform 2011; Volum 42 (5). ISSN 0931-7597.s doi: 10.1002/chin.201105195.

  • Tadesse, Margey; Svenson, Johan; Jaspars, Marcel; Strøm, Morten B.; Abdelrahman, Mostafa H.; Andersen, Jeanette hammer; Hansen, Espen; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities.. ChemInform 2011; Volum 42 (29). ISSN 0931-7597.s doi: 10.1002/chin.201129197.

  • Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tabudravu, Jioji N.; Tørfoss, Veronika; Hansen, Espen; Andersen, Jeanette hammer; Abdelrahman, Mostafa H.; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Antimicrobial compounds from cold-water marine organisms. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.

  • Tadesse, Margey; Strøm, Morten B.; Svenson, Johan; Jaspars, Marcel; Milne, Bruce F.; Tabudravu, Jioji N.; Tørfoss, Veronika; Hansen, Espen; Andersen, Jeanette hammer; Abdelrahman, Mostafa H.; Kristiansen, Per Eugen; Stensvåg, Klara; Haug, Tor. Antimicrobial compounds from cold-water marine organisms. BIT’s 1st Annual World Congress (WCMB-2011) 2011-04-25 - 2011-04-30 2011.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Tadesse, Margey; Haug, Tor; Strøm, Morten B.. Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates.. 2010 ISBN 978-82-9108-695-8.

  • Tadesse, Margey; Haug, Tor; Strøm, Morten B.; Stensvåg, Klara; Styrvold, Olaf B.. Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. MABCENT Science Days 2010-11-02 - 2010-11-03 2010.

  • Hansen, Terkel; Tore, Alst; Havelkova, Martina; Strøm, Morten B.. Antimicrobial activity of small β-peptidomimetics fulfilling the pharmacophore model of short cationic antimicrobial peptides. Norsk kjemisk vintermøte 2010-01-06 - 2010-01-10 2010.

  • Hansen, Terkel; Ausbacher, Dominik; Havelkova, Martina; Strøm, Morten B.. Bactericidal activity of small β-peptidomimetics. European Peptide Symposium 2010-09-05 - 2010-09-09 2010.

  • Tadesse, Margey; Tørfoss, Veronika; Strøm, Morten B.; Hansen, Espen; Andersen, Jeanette hammer; Stensvåg, Klara; Haug, Tor. 3-hydroxy-tubastrine from the sub-Arctic ascidian, Dendrodoa aggregata. BIOPROSP 2009 2009-02-24 - 2009-02-26 2009.

  • Tadesse, Margey; Tørfoss, Veronika; Vaagsfjord, Lena Christine; Strøm, Morten B.; Stensvåg, Klara; Haug, Tor; Jaspars, Marcel. Antimicrobial compounds in marine invertebrates from northern Norway. 38th Scottish Regional Meeting of the Organic Division of the Royal Society of Chemistry 2009-12-16 - 2009-12-16 2009.

  • Tadesse, Margey; Gulliksen, Bjørn; Strøm, Morten B.; Styrvold, Olaf B.; Haug, Tor. Screening for antimicrobial and antifungal activities in marine benthic invertebrates from Northern Norway. The Norwegian Biochemical Society 44th Contact Meeting 2008-01-17 - 2008-01-20 2008.

  • Michelsen, Vibeke Barman; Moe, Grete; Kopperud, Hilde Beate M.; Kleven, Inger Julie Sjøvik; Lygre, Gunvor Bentung; Svahn, Johanna; Strøm, Morten B.; Bjørkman, Lars; Jensen, Einar; Lygre, Henning. Monomers detected in saliva after treatment with compositte fillings. PEF IADR 2008 2008-09-10 - 2008-09-12 2008.

  • Michelsen, Vibeke Barman; Strøm, Morten Bøhmer; Jensen, Einar; Moe, Grete; Lygre, Henning. GC-MS ANALYSE AV UTLEKKSSTOFFER FRA POLYMERBASERTE DENTALE FYLLINGSMATERIALER. 12. Norske seminar i massespektrometri 2007-01-21 - 2007-01-24 2007.

  • Michelsen, Vibeke Barman; Moe, Grete; Strøm, Morten Bøhmer; Jensen, Einar; Lygre, Henning. Kvantifisering av utløste substanser fra polymerbaserte fyllingsmaterialer – analyser med GC/MS. NIOM, biomaterial network meeting 2006-11-08 - 2006-11-08 2006.

  • Publikasjoner utenfor Cristin

     

    Publikasjonsliste

    1. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S., Antibacterial activity of 15-residue lactoferricin derivatives. J. Peptide Res. 2000, 56, 265-274.
    2. Lejon, T.; Strøm, M. B.; Svendsen, J. S., Antibiotic activity of pentadecapeptides modelled from amino acid descriptors. J. Peptide Sci. 2001, 7, 74-81.
    3. Lejon, T.; Strøm, M. B.; Svendsen, J. S., Is information about peptide sequence necessary in multivariate analysis? Chemometrics and Intelligent Laboratory Systems 2001, 57, 93-95.
    4. Strøm, M. B.; Rekdal, Ø.; Stensen, W.; Svendsen, J. S., Increased antibacterial activity of 15-residue murine lactoferricin derivatives. J. Peptide Res. 2001, 57, 127-139.
    5. Strøm, M. B.; Haug, B. E.; Rekdal, Ø.; Skar, M. L.; Stensen, W.; Svendsen, J. S., Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity. Biochem Cell Biol. 2002, 80, 65-74.
    6. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S., Antimicrobial activity of short arginine- and tryptophan-rich peptides. J. Peptide Sci. 2002, 8, 431-437.
    7. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S., The effects of charge and lipophilicity on the antibacterial activity of undecapeptides derived from bovine lactoferricin. J. Peptide Sci. 2002, 8, 36-43.
    8. Strøm, M. B.; Haug, B. E.; Skar, M. L.; Stensen, W.; Stiberg, T.; Svendsen, J. S., The pharmacophore of short cationic antibacterial peptides. J. Med. Chem. 2003, 46, 1567-1570.
    9. Lejon, T.; Stiberg, T.; Strøm, M. B.; Svendsen, J. S., Prediction of antibiotic activity and synthesis of new pentadecapeptides based on lactoferricins. J. Peptide Sci. 2004, 10, 329-335.
    10. Moe, M. K.; Anderssen, T.; Strom, M. B.; Jensen, E., Vicinal hydroxylation of unsaturated fatty acids for structural characterization of intact neutral phospholipids by negative electrospray ionization tandem quadrupole mass spectrometry. Rapid Commun. Mass Spec. 2004, 18, (18), 2121-2130.
    11. Moe, M. K.; Strom, M. B.; Jensen, E.; Claeys, M., Negative electrospray ionization low-energy tandem mass spectrometry of hydroxylated fatty acids: A mechanistic study. Rapid Commun. Mass Spec. 2004, 18, (15), 1731-1740.
    12. Yang, N.; Strom, M. B.; Mekonnen, S. M.; Svendsen, J. S.; Rekdal, O., The effects of shortening lactoferrin derived peptides against tumor cells, bacteria and human normal cells. J. Peptide Sci. 2004, 10, (1), 37-46.
    13. Moe, M. K.; Anderssen, T.; Strøm, M. B.; Jensen, E., Total structure characterization of unsaturated acidic phospholipids provided by vicinal di-hydroxylation of fatty acid double bonds and negative electrospray ionization mass spectrometry. J. Am. Soc. Mass Spec. 2005, 16, (1), 46-59.
    14. Haug, B. E.; Strøm, M. B.; Svendsen, J. S., The medicinal chemistry of short lactoferricin-based antibacterial peptides. Curr. Med. Chem. 2007, 14, (1), 1-18.
    15. Michelsen, V. B.; Moe, G.; Strøm, M. B.; Jensen, E.; Lygre, H., Quantitative analysis of TEGDMA and HEMA eluted into saliva from two dental composites by use of GC/MS and tailor-made internal standards. Dental Materials 2008, 24, 724-731.
    16. Tadesse, M.; Gulliksen, B.; Strøm, M. B.; Styrvold, O. B.; Haug, T., Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway. J. Invertebrate Pathology 2008, 99, 286-293.
    17. Hansen, T.; Alst, T.; Havelkova, M.; Strøm, M. B., Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides. J. Med. Chem. 2010, 53, 595–606.
    18. Tadesse, M.; Tørfoss, V.; Strøm, M. B.; Hansen, E.; Andersen, J. H.; Stensvåg, K.; Haug, T., Isolation and biological activity of (E)-1-(4-hydroxystyryl)guanidine from the sub-Arctic ascidian, Dendrodoa aggregata. Biochemical Systematics and Ecology 2010, 38, 827–829.
    19. Tadesse, M.; Strøm, M. B.; Svenson, J.; Jaspars, M.; Milne, B. F.; Tørfoss, V.; Andersen, J. H.; Hansen, E.; Stensvåg, K.; Haug, T., Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria, Org. Lett. 2010, 12, 4752-4755.
    20. Tadesse, M.; Tabudravu, J. N.; Jaspars, M.; Strøm, M. B.; Hansen, E.; Andersen, J. H.; Kristiansen, P. E.,; Haug, T., The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan Tegella cf. spitzbergensis, J. Nat. Prod. 2011, 74, 837-841.
    21. Tadesse, M.; Svenson, J.; Jaspars, M.; Strøm, M. B.; Abdelrahman, M. H.; Andersen, J. H.; Hansen, E.; Kristiansen, P. E.; Stensvåg, K.; Haug, T., Synoxazolidinone C; a bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities, Tetrahedron Lett. 2011, 52, 1804-1806.
    22. Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm M. B., Synthesis of cationic antimicrobial β2,2-amino acid derivatives with potential for oral administration, J. Med. Chem. 2011, 54, 858-868.
    23. Tørfoss, V.; Ausbacher, D.A.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block, J. Peptide Sci. 2012, 18, 170-176.
    24. Hansen, T.; Moe, M. K.; Anderssen, T.; Strøm, M. B. Metabolism of small antimicrobial β2,2-amino acid derivatives by murine liver microsomes, Eur. J. Drug Metab. Pharmacokinet. 2012, 37,191–201.
    25. Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm, M.B. Anticancer mechanisms of action of two small amphipathic β2,2-amino acid derivatives derived from antimicrobial peptides. Biochim. Biophys. Acta – Biomembranes. 2012, 1818, 2917-2925.
    26. Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B-.O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C.deA.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M.B. Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β2,2-amino acid. J. Peptide Sci. 2012, 18, 609-619.
    27. Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm, M.B. Anticancer activity of small amphipathic β2,2-amino acid derivatives. Eur. J. Med. Chem. 2012, 58, 22-29.
    28. Ausbacher, D.; Fallarero, A.; Kujala, J.; Määttänen, A.; Peltonen, J.; Strøm, M.B.; Vuorela, P.M. Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling. 2014, 30, 81-93.
    29. Sivertsen, A.; Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Anderssen, T.; Brandsdal, B-.O;Havelkova, M.; Skjørholm, A.E.; Strøm, M.B. Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide-binding to human serum albumin. J. Peptide Sci. 2014, 20, 279-291.

    30. Hanski, L.; Ausbacher, D.; Tiirola, T.; Strøm, M.B.; Vuorela, P.M. Amphipathic β2,2-amino acid derivatives suppress infectivity and disrupt the intracellular replication cycle of Chlamydia pneumoniae. PLoS ONE. 2016, 11(6): e0157306. doi:10.1371/journal.pone.0157306.

    31. Paulsen, M.H.; Engqvist, M.; Ausbacher, D.;  Strøm, M.B.; Bayer, A. Efficient and scalable synthesis of α,α-disubstituted β-amino amides. Org. Biomol. Chem. 2016, 14, 7570-7578.

    32. Igumnova, E.M.; Mishchenko, E.; Haug, T.; Blencke, H.-M.;Ericson Sollid, J.U.; Fredheim, E.G.Aa.; Lauksund, S.; Stensvåg, K.; Strøm, M.B. Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL-CARBA producing multi-resistant bacteria. Bioorganic & Medicinal Chemistry. 2016, 24, 5884-5894.

    33. Bakka, T.A.; Strøm, M.B.; Andersen, J.H.; Gautun, O.R. Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles. Bioorganic & Medicinal Chemistry Letters. 2017, 27, 1119-1123.

    34. Bakka, T.A.; Strøm, M.B.; Andersen, J.H.; Gautun, O.R. Methyl propiolate and 3-butynone: starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation. Bioorganic & Medicinal Chemistry. 2017, 25, 5380-5395.
    35. Paulsen, M.H.; Karlsen, E.A.; Ausbacher, D.; Andersen, T.; Bayer, A.; Ochtrop, P.; Hedberg, C.; Haug, T.; Sollid, J.U.E.; Strøm, M.B. An amphipathic cyclic tetrapeptide scaffold containing halogenated beta2,2-amino acids with activity against multi-resistant bacteria. J. Peptide Sci. 2018;24:e3117. DOI: 10.1002/psc.3117
    36. Igumnova, E.M.; Mishchenko, E.; Haug, T.; Blencke, H.-M.; Sollid, J.U.E.; Aarag Fredheim, E.G.; Lauksund, S.; Stensvåg, K.; Strøm, M.B. Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates. Bioorg. Med. Chem. 2018, 26, 4930-4941. DOI: 10.1016/j.bmc.2018.08.032

    37. Paulsen, M.H., Ausbacher, D., Bayer, A., Engqvist, M., Hansen, T., Haug, T., Anderssen, T., Andersen, J.H., Sollid, J.U. E., Strøm, M.B. Antimicrobial activity of amphipathic alfa,alfa-disubstituted beta-amino amide derivatives against ESBL – CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. Eur. J. Med. Chem. 2019, accepted.

    Patenter

    1. Svendsen, J. S.; Haug, B. E.; Istvan, M.; Øystein, R.; Skar, M. L.; Stensen, W.; Strøm, M. B., Antimicrobial membrane-destabilizing peptidic compounds and formulations. 2001. WO  2001066147  (A2).
    2. Stroem, M.B.; Hansen, T.; Havelkova, M.; Tørfoss, V. Therapeutic peptides. 2011. WO 2011051692 (A1).
    3. Tadesse, M,; Stroem, M.B.; Svenson, J.; Jaspars M.; Stensvaag K.; Haug T. Bioactive alkaloids. WO2012035305  (A1).
    4. Strøm, M.B.; Bayer, A.; Engqvist, S.O.M.; Paulsen, M.H; Ausbacher, D. 2018. Barbituric acid derivatives comprising cationic and lipophilic groups. WO/2018/178198. PCT/EP2018/058011.

     

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