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Ellen Aasum

Professor
Institutt for medisinsk biologi

Stillingsbeskrivelse:

 

Professor at the Cardiovascular Research Group

"Fagenhetsansvarlig" in Physiology at the Department of Medical Biology




Forskningsinteresser

Current Research Interests:

Cardiac substrate metabolism, oxygen consumption and efficiency and its role in development of cardiac dysfunction associated with to obesity and diabetes.

Treatment of obesity/diabetes (anti-diabetic and anti-inflammatory treatment, exercise, nutritional supplements) with a special focus on the potential for cardioprotection.

Cardiometabolic phenotyping, using isolated perfused hearts for measurements of substrate utilization, intraventricular pressure-volume measurements, myocardial oxygen consumption, cardiac efficiency and ischemic susceptibility.

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EDUCATION
1998                PhD, University of Tromsø, Norway
1992                Master of Science, University of Tromsø, Norway
1990                Bachelor of Science, University of Oslo, Norway

 

RESEARCH POSITIONS
2002 -                   Associated Professor / Professor University of Tromsø
2006 - 2007         Visiting scientist, University of Oxford, UK
1999 - 2002         Post doctoral research fellow, University of Tromsø

Arbeider i CRIStin


  • Boardman, Neoma Tove; Rossvoll, Line; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen. 3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice. Frontiers in Physiology 2019; Volum 10 (1275). ISSN 1664-042X.s doi: 10.3389/fphys.2019.01274.

  • Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen. Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart. PLOS ONE 2018; Volum 13 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0204843.

  • Hansen, Synne Simonsen; Aasum, Ellen; Hafstad, Anne Dragøy. The role of NADPH oxidases in diabetic cardiomyopathy. Biochimica et Biophysica Acta - Molecular Basis of Disease 2018; Volum 1864 (5). ISSN 0925-4439.s 1908 - 1913.s doi: 10.1016/j.bbadis.2017.07.025.

  • Boardman, Neoma; Hafstad, Anne Dragøy; Lund, Jim; Rossvoll, Line; Aasum, Ellen. Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. American Journal of Physiology. Heart and Circulatory Physiology 2017; Volum 313 (5). ISSN 0363-6135.s 1054 - 1062.s doi: 10.1152/ajpheart.00382.2017.

  • Salma, Wahida; Franeková, Veronika; Lund, trine; Höper, Anje Christina; Ludvigsen, Stian; Lund, Jim; Aasum, Ellen; Ytrehus, Kirsti; Belke, Darrell D.; Larsen, Terje. Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 2016; Volum 108. ISSN 0952-3278.s 13 - 21.s doi: 10.1016/j.plefa.2016.03.006.

  • Cole, Mark A.; Jamil, Amira H. Abd; Heather, Lisa C; Murray, Andrew J; Sutton, Elizabeth R; Slingo, Mary; Sebag-Montefiore, Liam; Tan, Suat Cheng; Aksentijevic, Dunja; Gildea, Ottilie S; Stuckey, Daniel J; Yeoh, Kar Kheng; Carr, Carolyn A.; Evans, Rhys D.; Aasum, Ellen; Schofield, Christopher J.; Ratcliffe, Peter J.; Neubauer, Stefan; Robbins, Peter A.; Clarke, Kieran. On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. The FASEB Journal 2016; Volum 30 (8). ISSN 0892-6638.s 2684 - 2697.s doi: 10.1096/fj.201500094R.

  • Mansor, Latt S.; Metha, Keshavi; Aksentijevic, Dunja; Carr, Carolyn A.; Lund, trine; Cole, Mark A.; Page, Lydia Le; Fialho, Maria da Kuz Sousa; Shattock, Michael J.; Aasum, Ellen; Clarke, Kieran; Tyler, Damian J.; Heather, Lisa C.. Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. Journal of Physiology 2016; Volum 594 (2). ISSN 0022-3751.s 307 - 320.s doi: 10.1113/JP271242.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Aasum, Ellen. How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy. Antioxidants and Redox Signaling 2015; Volum 22 (17). ISSN 1523-0864.s doi: 10.1089/ars.2015.6304.

  • Lund, Jim; Hafstad, Anne Dragøy; Boardman, Neoma Tove; Rossvoll, Line; Rolim, Natale Pinheiro Lage; Ahmed, Muhammad Shakil; Florholmen, Geir; Attramadal, Håvard; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice. American Journal of Physiology. Heart and Circulatory Physiology 2015; Volum 308 (8). ISSN 0363-6135.s H823 - H829.s doi: 10.1152/ajpheart.00734.2014.

  • Bakkehaug, Jens Petter; Kildal, Anders Benjamin; Engstad, Erik Torgersen; Boardman, Neoma Tove; Næsheim, Torvind; Rønning, Leif R.; Aasum, Ellen; Larsen, Terje; Myrmel, Truls; How, Ole-Jakob. Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity. Circulation: Heart Failure 2015; Volum 8 (4). ISSN 1941-3289.s 766 - 775.s doi: 10.1161/CIRCHEARTFAILURE.114.002152.

  • Höper, Anje Christina; Salma, Wahida; Sollie, Selene Julie; Hafstad, Anne Dragøy; Lund, Jim; Khalid, Ahmed Murtaz; Raa, Jan; Aasum, Ellen; Larsen, Terje. Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. Journal of Nutrition 2014; Volum 144 (2). ISSN 0022-3166.s 164 - 169.s doi: 10.3945/jn.113.182501.

  • Boardman, Neoma Tove; Aronsen, Jan Magnus; Louch, William Edward; Sjaastad, Ivar; Willoch, Frode; Christensen, Geir Arve; Sejersted, Ole M; Aasum, Ellen. Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2. American Journal of Physiology. Heart and Circulatory Physiology 2014. ISSN 0363-6135.s doi: 10.1152/ajpheart.00741.2013.

  • Aasum, Ellen. Relationship Between Substrate Metabolism and Cardiac Efficiency. Springer Science+Business Media B.V. 2014 ISBN 978-1-4939-1226-1.s 103 - 114.s doi: 10.1007/978-1-4939-1227-8_7.

  • Boardman, Neoma Tove; Aronsen, Jan Magnus; Louch, William Edward; Sjaastad, Ivar; Willoch, Frode; Christensen, Geir Arve; Sejersted, Ole M; Aasum, Ellen. Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2. American Journal of Physiology. Heart and Circulatory Physiology 2014; Volum 306 (7). ISSN 0363-6135.s H1018 - H1024.s doi: 10.1152/ajpheart.00741.2013.

  • Hafstad, Anne Dragøy; Lund, Jim; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity. Diabetes 2013; Volum 62 (7). ISSN 0012-1797.s 2287 - 2294.s doi: 10.2337/db12-1580.

  • Höper, Anje Christina; Salma, Wahida; Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Sollie, Selene Julie; Raa, Jan; Larsen, Terje; Aasum, Ellen. Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013; Volum 110. ISSN 0007-1145.s 2186 - 2193.s doi: 10.1017/S0007114513001839.

  • von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil; Krobert, Kurt Allen; Levy, Finn Olav; Larsen, Terje; Smiseth, Otto A.; Aasum, Ellen; Attramadal, Håvard. Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology 2012; Volum 303 (1). ISSN 0363-6135.s H66 - H74.s doi: 10.1152/ajpheart.00724.2011.

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Boardman, Neoma Tove; Hagve, Martin; Berge, Rolf Kristian; Aasum, Ellen. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2011; Volum 300 (6). ISSN 0363-6135.s H2116 - H2122.s doi: 10.1152/ajpheart.00357.2010.

  • Aasum, Ellen. Myocardial energetics and efficiency. Hearts and Metabolism 2011; Volum 53. ISSN 1566-0338.s 5 - 8.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Khalid, Ahmed Murtaz; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. Journal of applied physiology 2011; Volum 111 (5). ISSN 8750-7587.s 1235 - 1241.s doi: 10.1152/japplphysiol.00594.2011.

  • Boardman, Neoma Tove; Larsen, Terje; Severson, david lester; Essop, M Fadiel; Aasum, Ellen. Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. American Journal of Physiology. Heart and Circulatory Physiology 2011; Volum 300 (5). ISSN 0363-6135.s H1631 - H1636.s doi: 10.1152/ajpheart.01190.2010.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Hagve, Martin; Lund, trine; Larsen, Terje; Severson, DL; Clarke, Kieran; Berge, Rolf; Aasum, Ellen. Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovascular Research 2009; Volum 83 (1). ISSN 0008-6363.s 519 - 526.s doi: 10.1093/cvr/cvp132.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, DL; Aasum, Ellen. Increased O-2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2009; Volum 296 (5). ISSN 0363-6135.s H1373 - H1379.s doi: 10.1152/ajpheart.01264.2008.

  • Stølen, Tomas O.; Høydal, Morten Andre; Kemi, Ole J.; Catalucci, Daniele; Ceci, Marcelle; Aasum, Ellen; Larsen, Terje; Rolim, Natalie; Condorelli, Gianluigi; Smith, Godfrey L.; Wisløff, Ulrik. Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy. (fulltekst) Circulation Research 2009; Volum 105. ISSN 0009-7330.s 527 - 536.s doi: 10.1161/CIRCRESAHA.109.199810.

  • Krishnan, Jaya; Suter, Marianne; Windak, Renata; Krebs, Tatiana; Felley, Allison; Montessuit, Christophe; Tokarska-Schlattner, Malgorzata; Aasum, Ellen; Bogdanova, Anna; Perriard, Evelyne; Perriard, Jean-Claude; Larsen, Terje; Pedrazzini, Thierry; Krek, Wilhelm. Activation of a HIF1 alpha-PPAR gamma Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy. Cell Metabolism 2009; Volum 9 (6). ISSN 1550-4131.s 512 - 524.s doi: 10.1016/j.cmet.2009.05.005.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, Oddrun Anita; How, Ole-Jakob; Berge, Rolf; Larsen, Terje. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. Journal of Molecular and Cellular Cardiology 2008; Volum 44 (201). ISSN 0022-2828.s 201 - 209.s doi: 10.1016/j.yjmcc.2007.08.020.

  • Kondratiev, Timofei; Wold, Ragnhild Margrete; Aasum, Ellen; Tveita, Torkjel. Myocardial mechanical dysfunction and calcium overload following rewarming from experimental hypothermia in vivo. Cryobiology 2008; Volum 56. ISSN 0011-2240.s 15 - 21.s doi: 10.1016/j.cryobiol.2007.09.005.

  • Vinge, Leif Erik; Von Lueder, Thomas; Aasum, Ellen; Qvigstad, Eirik; Gravning, Jørgen A.; How, Ole-Jakob; Edvardsen, Thor; Bjørnerheim, Reidar; Ahmed, M. Shakil; Mikkelsen, Birthe W.; Øie, Erik; Attramadal, Toril; Skomedal, Tor; Smiseth, Otto A; Koch, Walter J.; Larsen, Terje; Attramadal, Håvard. Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth – GRK3 controls cardiac a1-adrenergic receptor responsiveness. Journal of Biological Chemistry 2008; Volum 283. ISSN 0021-9258.s 10601 - 10610.s doi: 10.1074/jbc.M708912200.

  • Stuckey, Daniel J; Carr, Carolyn A; Tyler, Damian J; Aasum, Ellen; Clarke, Kieran. Novel MRI Method to Detect Altered Left Ventricular Ejection and Filling Patterns in Rodent Models of Disease. Magnetic Resonance in Medicine 2008; Volum 60 (3). ISSN 0740-3194.s 582 - 587.

  • Larsen, Terje; Aasum, Ellen. Metabolic (in)flexibility of the diabetic heart. Cardiovascular Drugs and Therapy 2008; Volum 22. ISSN 0920-3206.s 91 - 95.s doi: 10.1007/s10557-008-6083-1.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Myrray, AJ; Boardman, Neoma; Cole, M; Clarke, Kieran; Severson, David Lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice. Archives of Physiology and Biochemistry 2007; Volum 113 (4). ISSN 1381-3455.s 211 - 220.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. American Journal of Physiology. Endocrinology and Metabolism 2007; Volum 292. ISSN 0193-1849.s E1288 - E1294.s doi: 10.1152/ajpendo.00504.2006.

  • Hafstad, Anne Dragøy; Solevåg, Geir Helge; Severson, david lester; Larsen, Terje; Aasum, Ellen. Perfused hearts from type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. American Journal of Physiology. Heart and Circulatory Physiology 2006; Volum 290. ISSN 0363-6135.s H1763 - H1769.

  • How, Ole-Jakob; Aasum, Ellen; Severson, David Lester; Chan, A; Essop, M Fadiel; Larsen, Terje. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 2006; Volum 55. ISSN 0012-1797.s 466 - 473.

  • Oakes, ND; Thalen, P; Aasum, Ellen; Edgley, A; Larsen, Terje; Furler, SM; Ljung, B; Severson, David Lester. Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes. American Journal of Physiology. Endocrinology and Metabolism 2006; Volum 290. ISSN 0193-1849.

  • Pellieux, C; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway. Journal of Molecular and Cellular Cardiology 2006; Volum 41. ISSN 0022-2828.s 459 - 466.

  • Bratkovski, Serguei; Aasum, Ellen; Riemersma, Rudolph; Myhre, Eivind S. P.; Larsen, Terje. Reduced coronary reserve in response to short-term ischaemia and vasoactive drugs in ex vivo hearts from diabetic mice. Acta Physiologica 2006; Volum 186. ISSN 1748-1708.s 171 - 177.

  • Aasum, Ellen; Cooper, Marie; Severson, David Lester; Larsen, Terje. Effect of BM 17.0744, a PPAR alpha ligand, on the metabolism of perfused hearts from control and diabetic mice. Canadian Journal of Physiology and Pharmacology 2005; Volum 83. ISSN 0008-4212.s 183 - 190.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Myhre, Eivind S.p.; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. American Journal of Physiology. Heart and Circulatory Physiology 2005; Volum 288. ISSN 0363-6135.s H2979 - H2985.

  • Henden, Thale; Aasum, Ellen; Folkow, Lars; Mjøs, Ole Danbolt; Lathrop, David A; Larsen, Terje. Endogenous glycogen prevents Ca2+ overload and hypercontracture in harp seal myocardial cells during simulated ischemia. Journal of Molecular and Cellular Cardiology 2004; Volum 37. ISSN 0022-2828.s 43 - 50.s doi: 10.1016/j.yjmcc.2004.03.013.

  • Carley, Andrew; Semeniuk, LM; Shimoni, Y; Aasum, Ellen; Larsen, Terje; Berger, JP; Severson, David Lester. Treatment of type 2 diabetic db/db mice with a novel PPAR gamma agonist improves cardiac metabolism but not contractile function. American Journal of Physiology. Endocrinology and Metabolism 2004; Volum 286. ISSN 0193-1849.s E449 - E455.

  • Bratkovski, Serguei; Aasum, Ellen; Birkeland, CH; Riemersma, Rudolph; Myhre, Eivind SP; Larsen, Terje. Measurement of coronary flow reserve in isolated hearts from mice. Acta Physiologica Scandinavica 2004; Volum 181. ISSN 0001-6772.s 167 - 172.

  • Severson, David Lester; Aasum, Ellen; Belke, Darrell D; Larsen, Terje; Semeniuk, LM; Shimomi, Y. Diabetes and cardiac dysfunction. 2003.s 373 - 385.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje. Cardiac Age-dependent changes in metabolism, contractile function and ischemic sensitivity in hearts from db/db mice. Diabetes 2003; Volum 52. ISSN 0012-1797.s 434 - 441.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion. Molecular and Cellular Biochemistry 2003; Volum 249. ISSN 0300-8177.s 97 - 103.

  • Hafstad, Anne Dragøy; Aasum, Ellen; Lund, Jim; Celio X, Santos; Shah, Ajay. A role of NADPH oxidase in obesity-induced myocardial oxygen wasting. Society of Heart and Vascular Metabolism 2014 2015-06-24 - 2015-06-27 2015.

  • Bakkehaug, Jens Petter; Kildal, Anders Benjamin; Engstad, Erik Torgersen; Boardman, Neoma Tove; Næsheim, Torvind; Rønning, Leif R.; Aasum, Ellen; Larsen, Terje; Myrmel, Truls; How, Ole-Jakob. Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity". Circulation: Heart Failure 2015; Volum 8 (6). ISSN 1941-3289.s 1142 - 1142.s doi: 10.1161/CIRCHEARTFAILURE.115.002548.

  • Hafstad, Anne Dragøy; Lund, Jim; Aasum, Ellen; Santos, Celio X; Shah, Ajay. A role of NADPH oxidase in obesity-induced myocardial oxygen wasting. CRC: NOX Family NADPH oxidases 2014-05-18 - 2015-05-23 2014.

  • Aasum, Ellen. Cardiac Efficiency and Mechanoenergetics in Diabetic Cardiomyopathy. Burdon Sanderson Cardiac Science Centre Lecture Series 2014-12-04 - 2014.

  • Lund, Jim; Aasum, Ellen. The effect of nitrate/nitrite on cardiac energetics. 12th annual meeting of the Society for Heart and Vascular Metabolism 2014-06-24 - 2014-06-27 2014.

  • Aasum, Ellen. Cardiac efficiency and mechanoenergetics in diabetic cardiomyopathy. American Heart Association Scientific Sessions 2014-11-15 - 2014-11-19 2014.

  • Aasum, Ellen. Exercise and its beneficial role on the diabetic heart. Experimental Biology 2014-04-25 - 2014-04-30 2014.

  • Salma, Wahida; Höper, Anje Christina; Lund, trine; Ludvigsen, Stian; Ytrehus, Kirsti; Aasum, Ellen; Larsen, Terje. Dietary supply with Calanus oil antagonizes angiotensin IIinduced hypertension, cardiac hypertrophy and cachexia in obese mice. Society for heart and vascular metabolism (SHVM) 2013-09-29 - 2013-10-02 2013.

  • Hafstad, Anne Dragøy; Lund, Jim; Aasum, Ellen; Santos, C; Shah, Ajay. Prevention of obesity-induced myocardial oxygen-wasting through NADPH-oxidase inhibition. Høstmøte 2013 2013-10-17 - 2013-10-19 2013.

  • Salma, Wahida; Höper, Anje Christina; Khalid, Ahmed Murtaz; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen; Larsen, Terje. Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Salma, Wahida; Sollie, Selene Julie; Höper, Anje Christina; Khalid, Ahmed Murtaz; Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Hagve, Martin; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Höper, Anje Christina; Larsen, Terje; Khalid, Ahmed Murtaz; Salma, Wahida; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen. Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding. 3rd international congress on abdominal obesity 2012-07-09 - 2012-07-12 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Larsen, Terje; Aasum, Ellen. Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak. 10th Annual CHFR Symposium 2012-09-20 - 2012-09-21 2012.

  • Aasum, Ellen. Diabetic cardiomyopathy - metabolic interventions and exercise. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Circulation 2011; Volum 124. ISSN 0009-7322.s A14938 - .

  • Aasum, Ellen. Prevention of cardiac inefficiency in type 2 diabetes by means of high-intensity exercise training. 4th Seminar on Exercise in Medicine 2011-12-14 - 2011-12-15 2011.

  • Aasum, Ellen. Heart function and metabolism in type 2 diabetic db/db mice. SPS 2011-08-12 - 2011-08-14 2011.

  • Hagve, Martin; Sanden, Espen; Aasum, Ellen; Larsen, Terje. Palmitate-induced uncoupling reduces oxidative stress in cardiac mitochondria respiring on complex II substrate. 9th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2011-06-17 - 2011-06-21 2011.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice. 9th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2011-06-17 - 2011-06-21 2011.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Scientific Sessions 2011 of the American Heart Association 2011-11-12 - 2011-11-16 2011.

  • Høper, Anje Christina; Larsen, Terje; Lund, Jim; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Aasum, Ellen. Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.

  • Boardman, Neoma Tove; Aasum, Ellen. Cardiometabolic adaptations to altered fuel supply, Ca2+ handling and exercise. 2011 ISBN 978-82-7589-305-3.

  • Høper, Anje Christina; Khalid, Ahmed Murtaz; Fuglesteg, Britt Nanny; Aasum, Ellen; Larsen, Terje. Visceral fat deposition is attenuated by calanus oil supplementation in rats on a high fat diet. Cardiovascular Research 2010; Volum 87. ISSN 0008-6363.s S131 - S131.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Metabolic adaptations in the physiologically hypertrophied heart. 7th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2009-08-23 - 2009-08-26 2009.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. Circulation 2009. ISSN 0009-7322.s S880 - .

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. American Heart Association 2009-11-14 - 2009-11-18 2009.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Berge, Rolf; Larsen, Terje. TTA - the first PPAR ligand shown to increase fatty acid oxidation in normal and diabetic myocardium when administered in vivo. ISHR, Heart failure 2009 2009-05-30 - 2009-06-02 2009.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Larsen, Terje. Reduced lipid supply without a concomitant reduced glucose supply fails to alter the metabolic phenotype of diabetic hearts. ISHR XXVIII European Section Meeting 2008-05-28 - 2008-05-31 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, K; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. Cardiovascular Drugs and Therapy 2008; Volum 22. ISSN 0920-3206.s 142 - 143.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Reduced lipid supply without a concomitant reduced glucose supply fails to alter the metabolic phenotype of diabetic hearts. Journal of Molecular and Cellular Cardiology 2008; Volum 44 (4). ISSN 0022-2828.s 803 - .s doi: 10.1016/j.yjmcc.2008.02.219.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 128 - .

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 126 - .

  • Aasum, Ellen. Metabolic modulation and cardiac efficiency. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. The O2 cost of basal metabolism and excitation-contraction coupling is increased in hearts from type 2 diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Boardman, Neoma Tove; Larsen, Terje; Aasum, Ellen. The pan ppar ligand tta has a direct cardiometabolic effect in normal and diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, Kieran; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. 4th annual meeting of the Society for Heart and Vascular Metabolism 2007-06-18 - 2007-06-20 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. Journal of Molecular and Cellular Cardiology 2007; Volum 42. ISSN 0022-2828.s doi: 10.1016/j.yjmcc.2007.03.784.

  • Gravning, J; Von Lueder, Thomas; Edvardsen, T; Vinge, Leif Erik; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload. European Heart Journal 2007; Volum 28. ISSN 0195-668X.

  • How, Ole-Jakob; Aasum, Ellen; Larsen, Terje. Work-independent assessment of efficiency in ex vivo working rodent hearts within the PVA-MVO2 framework. Acta Physiologica 2007; Volum 190. ISSN 1748-1708.s 171 - 175.s doi: 10.1111/j.1748-1716.2006.01681.x.

  • Hafstad, Anne Dragøy; Aasum, Ellen. Metabolic modulation of the diabetic heart – Its impact on cardiac efficiency and ischemic tolerance. A study on substrate metabolism, contractile function and efficiency in isolated working mouse hearts. 2007 ISBN 978-82-7589-180-6.

  • Gravning, J; Von Lueder, Thomas; Edvardsen, T; Vinge, Leif Erik; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload. ESC Congress 2007-08-31 - 2007-09-05 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. XIX World congress of the ISHR 2007-06-22 - 2007-06-25 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice. Diabeteskonferansen 2007-02-07 - 2007-02-09 2007.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone improves cardiac efficiency and recovery of ventricular function following ischemia in hearts from type 2 diabetic mice. Heart Failure 2006 2006-06-13 - 2006-06-21 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. Journal of Molecular and Cellular Cardiology 2006; Volum 40 (6). ISSN 0022-2828.s 932 - .

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, OA; Larsen, Terje; Berge, Rolf. Indirect and direct effects of PPAR ligands on myocardial metabolism. Journal of Molecular and Cellular Cardiology 2006; Volum 40. ISSN 0022-2828.s 931 - 932.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Larsen, Terje. Improved cardiac metabolism enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114 (18). ISSN 0009-7322.

  • Graving, JA; Von Leuder, T; Edvardsen, T; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Vinge, Leif Erik; Mikkelsen, BV; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload. Circulation 2006; Volum 114. ISSN 0009-7322.s 97 - 97.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114. ISSN 0009-7322.s 136 - 136.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improves cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 408 - 409.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 410 - 411.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. The type 2 diabetic heart is not an insulin resistant organ. Exercise in Medicine 2006-12-14 - 2006-12-15 2006.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. 2006 Scientific Session 2006-11-12 - 2006-11-15 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. 26th Annual Scientific Sessions, European Section 2006-06-14 - 2006-06-16 2006.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, OA; Larsen, Terje; Berge, Rolf. Indirect and direct effects of PPAR ligands on myocardial metabolism. 26th European Section Meeting of the International Society for Heart Research 2006-06-14 - 2006-06-17 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improve cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. 4th Annual Meeting of the Society for Heart and Vascular Metabolism 2006-09-06 - 2006-09-09 2006.

  • Graving, JA; Von Lueder, Thomas; Edvardsen, T; How, Ole-Jakob; Aasum, Ellen; Ahmed, MS; Vinge, LE; Mikkelsen, BV; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Inhibition of G Protein-Coupled Receptor Kinase-3 (GRK3) rescues Cardiac dysfunction after pressure overload. 2006 Scientific Session 2006-11-12 - 2006-11-15 2006.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. 4th. Annual meeting 2006-09-06 - 2006-09-09 2006.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy?. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy?. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1029 - 1029.

  • Vader, Marit Arianne; Essop, M Fadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1077 - 1077.

  • Aasum, Ellen. Ventricular function and energy metabolism in type 2 diabetic hearts. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1087 - 1087.

  • Pellieux, Corrinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaptation during progression from cardiac phenotype to hearts failure. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1057 - 1057.

  • Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. Hjerteforum 2005; Volum 2 (178). ISSN 0802-1465.

  • Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. Kardiologisk vintermøte 2005-01-28 - 2005-01-30 2005.

  • How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Chan, A; Essop, M Fadiel; Larsen, Terje. Cardiac Efficiency is Reduced in Hearts from Diabetic Mice. 3rd. annual meeting of the Society for Heart and Vascular Metabolism 2005-09-26 - 2005-09-29 2005.

  • Aasum, Ellen. Ventricular function and energy metabolism in type 2 diabetic hearts. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Vader, Marit Arianne; Essop, Faadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Pellieux, Corinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaption during progression from cardiac hypertrophy to heart failure. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Thalen, P; Egdley, D; Severson, David Lester; Aasum, Ellen; Larsen, Terje; Ljung, B; Oakes, Nick. Cardiac metabolic inflexibility in diabetic (db/db) mice as shown by assessment of free fatty acid and glucose utilization in vivo. Second annual meeting of the Society for Heart and Vascular Metabolism 2004-09-09 - 2004-09-11 2004.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, by pressure-volume analysis in ex vivo mouse hearts. Journal of Molecular and Cellular Cardiology 2004; Volum 36. ISSN 0022-2828.s 735 - 735.

  • Solevåg, Geir Helge; Aasum, Ellen. Insulinresistens i myocytter fra type 2 diabetiske db/db mus. 2004.

  • Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of the receptor kinase GRK3 in transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. American Heart Associaction 2004-11-07 - 2004.

  • Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Transgenic mice with cardiac-specific inhibition of GRK3 display phenotype with cardiac hypertrophy and alpha1-adrenergic receptor hyperresponsiveness. ESC Meeting 2004-08-01 - 2004.

  • Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, Oddrun Anita; How, Ole-Jacob; Berge, Rolf; Larsen, Terje. Different effects of PPAR ligands on cardiac metabolism in mice fed high fat diet. Second annual meeting of the Society for Heart and Vascular Metabolism 2004-09-09 - 2004-09-11 2004.

  • Aasum, Ellen. Cardiac metabolism, function and efficiency recordings in ex vivo mouse hearts. ISHR, XVIII World Congress 2004-08-06 - 2004-08-11 2004.

  • How, Ole-Jacob; Aasum, Ellen; Kunnathu, Stanley; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. ISHR 2004-06-05 - 2004.

  • Aasum, Ellen. Metabolske og funksjonelle endringer i pre(diabetiske) hjerter. Diabetesforskningskonferansen 2004-09-30 - 2004-10-01 2004.

  • Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje; Aasum, Ellen. Hearts from type 2 diabetic (db/db) are highly sensitive to insulin. Heart Failure/ISHR ESC Meeting 2003-06-21 - 2003-06-23 2003.