Forskningsinteresser

I have 16 years of experience within the basal research in cardiac metabolism/energetics, and diabetes/obesity, using the isolated working heart set up with a repertoire of experimental biochemical techniques. My area of expertise is measurements of myocardial substrate uptake and oxidation rates as well as assessment of cardiac function and mechanoenergetics in isolated working mouse hearts. In my Post-Doc I was studying cardiac adaptations following intensity controlled treadmill running of rodents with a focus on exercise-induced effects on cardiac function, metabolism and mechanoenergetics in lean and obese models. Lately my focus has been on the ROS producing enzymes: NADPH oxidases and their role redox signalling in the heart. I have been studing their roles in cardiac metabolism, hypertrophic responses, exercise adaptation, in the development of diabetic ventricular and energetic dysfunction and cardiac metabolism. Lately I have gained an interest for cardiotoxicity induced by anticancer therapies and have received funding to investigate the cardiometabolic response to anticancer therapies in cell lines and an animal model.

 

Arbeider i CRIStin


  • Songstad, Nils Thomas; Kaspersen, Knut-Helge; Hafstad, Anne Dragøy; Acharya, Ganesh. Høyintesitets intervalltrening hos gravide rotter. Perinataldagene 2012 2012-11-07 - 2012-11-09 2012.
  • Boardman, Neoma Tove; Rossvoll, Line; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen. 3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice. Frontiers in Physiology 2019; Volum 10 (1275). ISSN 1664-042X.s doi: 10.3389/fphys.2019.01274.

  • Pedersen, Tina Myhre; Boardman, Neoma; Hafstad, Anne Dragøy; Aasum, Ellen. Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart. PLOS ONE 2018; Volum 13 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0204843.

  • Hancock, Matthew; Hafstad, Anne Dragøy; Nabeebaccus, Adam A.; Catibog, Norman; Logan, Angela; Smyrnias, Ioannis; Hansen, Synne Simonsen; Lanner, Johanna; Schröder, Katrin; Murphy, Michael P.; Shah, Ajay M.; Zhang, Min. Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. eLIFE 2018; Volum 7:E41044. ISSN 2050-084X.s 1 - 16.s doi: 10.7554/eLife.41044.

  • Hansen, Synne Simonsen; Aasum, Ellen; Hafstad, Anne Dragøy. The role of NADPH oxidases in diabetic cardiomyopathy. Biochimica et Biophysica Acta - Molecular Basis of Disease 2018; Volum 1864 (5). ISSN 0925-4439.s 1908 - 1913.s doi: 10.1016/j.bbadis.2017.07.025.

  • Boardman, Neoma; Hafstad, Anne Dragøy; Lund, Jim; Rossvoll, Line; Aasum, Ellen. Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. American Journal of Physiology. Heart and Circulatory Physiology 2017; Volum 313 (5). ISSN 0363-6135.s 1054 - 1062.s doi: 10.1152/ajpheart.00382.2017.

  • Santos, Celio X.C.; Hafstad, Anne Dragøy; Beretta, Matteo; Zhang, Min; Molenaar, Chris; Kopec, Jola; Fotinou, Dina; Murray, Thomas V.; Cobb, Andrew M.; Martin, Daniel; Zeh Silva, Maira; Anilkumar, Narayana; Schröder, Katrin; Shanahan, Catherine M.; Brewer, Alison C.; Brandes, Ralf P.; Blanc, Eric; Parsons, Maddy; Belousov, Vsevelod; Cammack, Richard; Hider, Robert C.; Steiner, Roberto A.; Shah, Ajay M.. Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling. EMBO Journal 2016; Volum 35 (3). ISSN 0261-4189.s 319 - 334.s doi: 10.15252/embj.201592394.

  • Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers. Journal of Cellular Physiology 2015; Volum 230 (1). ISSN 0021-9541.s 160 - 169.s doi: 10.1002/jcp.24694.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Aasum, Ellen. How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy. Antioxidants and Redox Signaling 2015; Volum 22 (17). ISSN 1523-0864.s doi: 10.1089/ars.2015.6304.

  • Songstad, Nils Thomas; Kaspersen, Knut-Helge; Hafstad, Anne Dragøy; Basnet, Purusotam; Ytrehus, Kirsti; Acharya, Ganesh. Effects of high intensity interval training on pregnant rats, and the placenta, heart and liver of their fetuses. PLOS ONE 2015; Volum 10 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0143095.

  • Lund, Jim; Hafstad, Anne Dragøy; Boardman, Neoma Tove; Rossvoll, Line; Rolim, Natale Pinheiro Lage; Ahmed, Muhammad Shakil; Florholmen, Geir; Attramadal, Håvard; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice. American Journal of Physiology. Heart and Circulatory Physiology 2015; Volum 308 (8). ISSN 0363-6135.s H823 - H829.s doi: 10.1152/ajpheart.00734.2014.

  • Höper, Anje Christina; Salma, Wahida; Sollie, Selene Julie; Hafstad, Anne Dragøy; Lund, Jim; Khalid, Ahmed Murtaz; Raa, Jan; Aasum, Ellen; Larsen, Terje. Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. Journal of Nutrition 2014; Volum 144 (2). ISSN 0022-3166.s 164 - 169.s doi: 10.3945/jn.113.182501.

  • Höper, Anje Christina; Salma, Wahida; Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Sollie, Selene Julie; Raa, Jan; Larsen, Terje; Aasum, Ellen. Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013; Volum 110. ISSN 0007-1145.s 2186 - 2193.s doi: 10.1017/S0007114513001839.

  • Hafstad, Anne Dragøy; Nabeebaccus, Adam; Shah, Ajay. Novel aspects of ROS signalling in heart failure. Basic Research in Cardiology 2013; Volum 108 (4:359). ISSN 0300-8428.s doi: 10.1007/s00395-013-0359-8.

  • Hafstad, Anne Dragøy; Lund, Jim; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High- and Moderate-Intensity Training Normalizes Ventricular Function and Mechanoenergetics hi Mice With Diet-Induced Obesity. Diabetes 2013; Volum 62 (7). ISSN 0012-1797.s 2287 - 2294.s doi: 10.2337/db12-1580.

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Boardman, Neoma Tove; Hagve, Martin; Berge, Rolf Kristian; Aasum, Ellen. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2011; Volum 300 (6). ISSN 0363-6135.s H2116 - H2122.s doi: 10.1152/ajpheart.00357.2010.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Khalid, Ahmed Murtaz; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. Journal of applied physiology 2011; Volum 111 (5). ISSN 8750-7587.s 1235 - 1241.s doi: 10.1152/japplphysiol.00594.2011.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Hagve, Martin; Lund, trine; Larsen, Terje; Severson, DL; Clarke, Kieran; Berge, Rolf; Aasum, Ellen. Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovascular Research 2009; Volum 83 (1). ISSN 0008-6363.s 519 - 526.s doi: 10.1093/cvr/cvp132.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, DL; Aasum, Ellen. Increased O-2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice. American Journal of Physiology. Heart and Circulatory Physiology 2009; Volum 296 (5). ISSN 0363-6135.s H1373 - H1379.s doi: 10.1152/ajpheart.01264.2008.

  • Stensløkken, Kåre-Olav; Rutkovskiy, Arkady; Kaljusto, Mari-Liis; Hafstad, Anne Dragøy; Larsen, Terje; Vaage, Jarle. Inadvertent phosphorylation of survival kinases in isolated perfused hearts: a word of caution. Basic Research in Cardiology 2009; Volum 104 (4). ISSN 0300-8428.s 412 - 423.s doi: 10.1007/s00395-009-0780-1.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Myrray, AJ; Boardman, Neoma; Cole, M; Clarke, Kieran; Severson, David Lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice. Archives of Physiology and Biochemistry 2007; Volum 113 (4). ISSN 1381-3455.s 211 - 220.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. American Journal of Physiology. Endocrinology and Metabolism 2007; Volum 292. ISSN 0193-1849.s E1288 - E1294.s doi: 10.1152/ajpendo.00504.2006.

  • Hafstad, Anne Dragøy; Solevåg, Geir Helge; Severson, david lester; Larsen, Terje; Aasum, Ellen. Perfused hearts from type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. American Journal of Physiology. Heart and Circulatory Physiology 2006; Volum 290. ISSN 0363-6135.s H1763 - H1769.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje. Cardiac Age-dependent changes in metabolism, contractile function and ischemic sensitivity in hearts from db/db mice. Diabetes 2003; Volum 52. ISSN 0012-1797.s 434 - 441.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion. Molecular and Cellular Biochemistry 2003; Volum 249. ISSN 0300-8177.s 97 - 103.

  • Hafstad, Anne Dragøy; Aasum, Ellen; Lund, Jim; Celio X, Santos; Shah, Ajay. A role of NADPH oxidase in obesity-induced myocardial oxygen wasting. Society of Heart and Vascular Metabolism 2014 2015-06-24 - 2015-06-27 2015.

  • Hafstad, Anne Dragøy. Trening normaliserte hjertefunksjonen hos overvektige mus. (data) 2014.

  • Hafstad, Anne Dragøy; Lund, Jim; Aasum, Ellen; Santos, Celio X; Shah, Ajay. A role of NADPH oxidase in obesity-induced myocardial oxygen wasting. CRC: NOX Family NADPH oxidases 2014-05-18 - 2015-05-23 2014.

  • Hafstad, Anne Dragøy. Positive effekter av trening på hjertets forbrenning ved fedme og diabetes. Idrettsmedisinsk Høstkongress 2014-11-07 - 2014-11-09 2014.

  • Hafstad, Anne Dragøy. Hjertegod trening ved fedme og diabetes. Seminar serie Tromsø Rotary 2014-12-04 - 2014-12-04 2014.

  • Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers. Gordon Research Conference on MMPs 2013-05-19 - 2013-05-24 2013.

  • Hafstad, Anne Dragøy; Lund, Jim; Aasum, Ellen; Santos, C; Shah, Ajay. Prevention of obesity-induced myocardial oxygen-wasting through NADPH-oxidase inhibition. Høstmøte 2013 2013-10-17 - 2013-10-19 2013.

  • Hafstad, Anne Dragøy. Hjertegod trening av feite mus. Lørdags universitetet 2013-09-07 - 2013-09-07 2013.

  • Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Kaspersen, Knut-Helge; Songstad, Nils Thomas; Hafstad, Anne Dragøy; Acharya, Ganesh. High intensity training in pregnant rats. European Congress of Periantal Medicine 2012-06-13 - 2012-06-16 2012.

  • Songstad, Nils Thomas; Kaspersen, Knut-Helge; Hafstad, Anne Dragøy; Acharya, Ganesh. Høyintesitets intervalltrening hos gravide rotter. Perinataldagene 2012 2012-11-07 - 2012-11-09 2012.

  • Salma, Wahida; Höper, Anje Christina; Khalid, Ahmed Murtaz; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen; Larsen, Terje. Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Salma, Wahida; Sollie, Selene Julie; Höper, Anje Christina; Khalid, Ahmed Murtaz; Lund, Jim; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Hagve, Martin; Hadler-Olsen, Elin Synnøve; Höper, Anje Christina; Larsen, Terje; Aasum, Ellen. High and moderate intensity training prevent diet-induced impairments in cardiac mechanoenergetics and ventricular function. 10th annual meeting of the Society for Heart and Vascular Metabolism 2012-06-24 - 2012-06-27 2012.

  • Höper, Anje Christina; Larsen, Terje; Khalid, Ahmed Murtaz; Salma, Wahida; Sollie, Selene Julie; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen. Low-dose supplementation with Calanus oil attenuates visceral adiposity and low-grade inflammation during high fat feeding. 3rd international congress on abdominal obesity 2012-07-09 - 2012-07-12 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Larsen, Terje; Aasum, Ellen. Cardiovascular Research Group, Faculty of Health Sciences, University of Tromsø, Norway. Exercise training prevent obesity-induced impairment of myocardial function and mechanoenergetics, as well as mitochondrial capacity and fatty acid-induced proton leak. 10th Annual CHFR Symposium 2012-09-20 - 2012-09-21 2012.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Circulation 2011; Volum 124. ISSN 0009-7322.s A14938 - .

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. High intensity interval training normalizes cardiac energetics and ventricular function in diet-induced obese mice. 9th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2011-06-17 - 2011-06-21 2011.

  • Hafstad, Anne Dragøy; Lund, Jim; Høper, Anje Christina; Hadler-Olsen, Elin Synnøve; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise improves ventricular function and decreases myocardial oxygen waste in diet-induced obese mice. Scientific Sessions 2011 of the American Heart Association 2011-11-12 - 2011-11-16 2011.

  • Høper, Anje Christina; Larsen, Terje; Lund, Jim; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Aasum, Ellen. Oil extracted from the marine copepod Calanus finmarchicus reduces diet-induced obesity and insulin resistance, and improves aerobic capacity in mice. BIOPROSP 2011 2011-02-23 - 2011-02-25 2011.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Metabolic adaptations in the physiologically hypertrophied heart. 7th annual meeting of the Society for Heart and Vascular Metabolism (SHVM) 2009-08-23 - 2009-08-26 2009.

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. Circulation 2009. ISSN 0009-7322.s S880 - .

  • Hafstad, Anne Dragøy; Boardman, Neoma Tove; Lund, Jim; Hagve, Martin; Wisløff, Ulrik; Larsen, Terje; Aasum, Ellen. Exercise-induced Increase In Cardiac Efficiency - The Impact of Intensity. American Heart Association 2009-11-14 - 2009-11-18 2009.

  • Aasum, Ellen; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Berge, Rolf; Larsen, Terje. TTA - the first PPAR ligand shown to increase fatty acid oxidation in normal and diabetic myocardium when administered in vivo. ISHR, Heart failure 2009 2009-05-30 - 2009-06-02 2009.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Boardman, Neoma Tove; Larsen, Terje; Aasum, Ellen. The pan ppar ligand tta has a direct cardiometabolic effect in normal and diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, K; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. Cardiovascular Drugs and Therapy 2008; Volum 22. ISSN 0920-3206.s 142 - 143.

  • Stenslokken, KO; Rutkovsky, A; Kaijusto, ML; Hafstad, Anne Dragøy; Larsen, Terje; Vaage, J. Degree of phosphorylation of survival kinases in isolated mouse hearts depends on the mode of perfusion. Journal of Molecular and Cellular Cardiology 2008; Volum 44. ISSN 0022-2828.s 711 - 825.s doi: 10.1016/j.yjmcc.2008.02.234.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Larsen, Terje. Reduced lipid supply without a concomitant reduced glucose supply fails to alter the metabolic phenotype of diabetic hearts. Journal of Molecular and Cellular Cardiology 2008; Volum 44 (4). ISSN 0022-2828.s 803 - .s doi: 10.1016/j.yjmcc.2008.02.219.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 128 - .

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Hjerteforum 2008; Volum 2. ISSN 0802-1465.s 126 - .

  • Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Lund, trine; Larsen, Terje; Severson, david lester; Berge, Rolf; Clarke, Kieran; Aasum, Ellen. Administration of tetradecylthioacetic acid (TTA) in mice accelerates myocardial FA oxidation via increased expression of pparα target genes. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. Oxygen cost of E-C coupling in the diabetic heart. Kardiologisk vintermøte 2008-02-01 - 2008-02-03 2008.

  • Boardman, Neoma Tove; Hafstad, Anne Dragøy; Larsen, Terje; Severson, david lester; Aasum, Ellen. The O2 cost of basal metabolism and excitation-contraction coupling is increased in hearts from type 2 diabetic mice. 6th annual meeting of the SHVM 2008-06-29 - 2008-07-01 2008.

  • Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne Dragøy; Clarke, Kieran; Berge, Rolf; Larsen, Terje. TTA is a pan PPAR ligand which markedly stimulates fatty acid oxidation following in vivo administration. 4th annual meeting of the Society for Heart and Vascular Metabolism 2007-06-18 - 2007-06-20 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. Journal of Molecular and Cellular Cardiology 2007; Volum 42. ISSN 0022-2828.s doi: 10.1016/j.yjmcc.2007.03.784.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Tjonna, Arnt E.; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed Ryr-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training. Medicine & Science in Sports & Exercise 2007; Volum 39. ISSN 0195-9131.

  • Hafstad, Anne Dragøy; Aasum, Ellen. Metabolic modulation of the diabetic heart – Its impact on cardiac efficiency and ischemic tolerance. A study on substrate metabolism, contractile function and efficiency in isolated working mouse hearts. 2007 ISBN 978-82-7589-180-6.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed RyR-leakage and improved contractile function in cardiomyocytes from type-2 diabetic heart after exercise training. ESC Congress 2007 2007-08-31 - 2007-09-05 2007.

  • Hafstad, Anne Dragøy. Impact of cardiac metabolism efficiency and ischemic tolerance. Research Symposium of the Norwegian Cardiology Society 2007-01-26 - 2007-01-28 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Berge, Rolf; Larsen, Terje; Aasum, Ellen. In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function. XIX World congress of the ISHR 2007-06-22 - 2007-06-25 2007.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice. Diabeteskonferansen 2007-02-07 - 2007-02-09 2007.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone improves cardiac efficiency and recovery of ventricular function following ischemia in hearts from type 2 diabetic mice. Heart Failure 2006 2006-06-13 - 2006-06-21 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. Journal of Molecular and Cellular Cardiology 2006; Volum 40 (6). ISSN 0022-2828.s 932 - .

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Larsen, Terje. Improved cardiac metabolism enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114 (18). ISSN 0009-7322.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. Circulation 2006; Volum 114. ISSN 0009-7322.s 136 - 136.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improves cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 408 - 409.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. Cardiovascular Drugs and Therapy 2006; Volum 20. ISSN 0920-3206.s 410 - 411.

  • Stølen, Thomas; Kemi, Ole J.; Høydal, Morten A.; Bye, Anja; Tjonna, Arnt E.; Hafstad, Anne Dragøy; Larsen, Terje; Smith, Godfrey L.; Wisløff, Ulrik. Reversed RyR-leakage And Improved Contractile Function In Cardiomyocytes From Type-2 Diabetic Heart After Exercise Training. Seminar on Exercise in Medicine 2006-12-14 - 2006-12-15 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. The type 2 diabetic heart is not an insulin resistant organ. Exercise in Medicine 2006-12-14 - 2006-12-15 2006.

  • Aasum, Ellen; Hafstad, Anne Dragøy; How, Ole-Jakob; Khalid, Ahmed Murtaz; Severson, david lester; Larsen, Terje. Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes. 2006 Scientific Session 2006-11-12 - 2006-11-15 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice. 26th Annual Scientific Sessions, European Section 2006-06-14 - 2006-06-16 2006.

  • Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; How, Ole-Jakob; Larsen, Terje; Aasum, Ellen. Elevated glucose and insulin improve cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. 4th Annual Meeting of the Society for Heart and Vascular Metabolism 2006-09-06 - 2006-09-09 2006.

  • How, Ole-Jakob; Larsen, Terje; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Myhre, Eivind S. P.; Severson, david lester; Aasum, Ellen. Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice. 4th. Annual meeting 2006-09-06 - 2006-09-09 2006.

  • Vader, Marit Arianne; Essop, Faadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. European Section of International Society for Heart Research 2005-06-21 - 2005-06-25 2005.

  • Vader, Marit Arianne; Essop, M Fadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. Journal of Molecular and Cellular Cardiology 2005; Volum 38. ISSN 0022-2828.s 1077 - 1077.

  • Hafstad, Anne Dragøy. Insulin sensitivity in hearts from type 2 diabetic (db/db) mice. Hjerteforum 2005; Volum 2 (178). ISSN 0802-1465.

  • Hafstad, Anne Dragøy. Insulin sensitivity in hearts from type 2 diabetic (db/db) mice. Kardiologisk vintermøte 2005-01-28 - 2005-01-30 2005.

  • Hafstad, Anne Dragøy; Severson, David Lester; Larsen, Terje; Aasum, Ellen. Hearts from type 2 diabetic (db/db) are highly sensitive to insulin. Heart Failure/ISHR ESC Meeting 2003-06-21 - 2003-06-23 2003.

  • Publikasjoner utenfor Cristin

    A. A. Nabeebaccus, A. Zoccarato, A. D. Hafstad, C. X.C. Santos, E. Aasum, A. C. Brewer, M. Zhang, M. Beretta, X. Yin, J. A. West, K. Schröder, J. L. Griffin, T. R. Eykyn, E. D Abel, M. Mayr, and A. M. Shah. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. Journal of Clinical Investigation (JCI) Insight. 2018. Ahead of print.

     

    Hafstad. AD. NADPH oksidaser i diabetisk hjertesykdom BestPractise. Diabetes/Hjerte-Kar sykdommer. 2018. Review. Ahead of print.

     

    S.S. Hansen, E. Aasum, A.D. Hafstad, The role of NADPH oxidases in diabetic cardiomyopathy, Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, (2017). Review. Ahead of print

     

    N.T. Boardman, A.D. Hafstad, J. Lund, L. Rossvoll, E. Aasum. Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load. American Journal of Physiology-Heart and Circulatory Physiology, 313 (2017) H1054-H1062.