Flag icon Flag icon

Synnøve Magnussen

Forsker
Institutt for medisinsk biologi

Stillingsbeskrivelse:

Forsker og forskningsgruppeleder




Forskningsinteresser

Min forskningsinteresse spenner tumorbiologi generelt og med et spesielt fokus på tumormikromiljøet. Jeg har tidligere jobbet med proteolytiske enzymer og deres roller i invasjon og spredning. Jeg har også jobbet med matrix metalloproteaser og plasminogen ativator systemet med spesielt fokus på reseptoren uPAR. I min postdoktor periode har jeg fokusert på brystkreft og uttrykket av det ekstracellulære proteinet nephronectin (NPNT). Vi fant at NPNT var med på å fremme spredning av brystkreft. Jeg er også interessert i cellene i tumormikromiljøet, med spesiell interesse for fibroblaster og endotelceller og deres rolle i kreftens utvikling.

Jeg er nå involvert i studier på oralkreft, blant annet gjennom et multisenter studie; NORwegian Oral Cancer study (NOROC). I NOROC studien leter vi etter prognostiske markører som kan implementeres i klinisk praksis og bedre behandlingen for oralkreftpasienter.

CV

2019-current:     Research group leader, Tumour Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø – The Arctic University of Norway

2018-2019:     Research group leader (50% shared with Qalbi Kahn), Tumour Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø – The Arctic University of Norway

2018-2022:         Researcher, Tumour Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø – The Arctic University of Norway

2015-2016:         One year visiting the Biological Research Centre, Centre of Excellence of EU, Szeged, Hungary and Professor Istvan Krizbai’s lab. Working on brain metastasis and the blood-brain-barrier

2015-2018:         Post Doctoral Fellow, Tumour Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT – The Arctic University of Norway. Project: The metastasis-promoting protein Nephronectin: distribution and mechanisms of action.

2011:                  Visiting PhD-student, Uppsala University, BMC, Department of Medical Biochemistry and Microbiology, Professor Staffan Johansson’s lab learning total internal reflection fluorescence microscopy (TIRF) microscopy (1 month)

2009-2015:         PhD in Tumour Biology, Department of Medical Biology, Faculty of Health Sciences, UiT- The Arctic University of Norway. Project: Oral Squamous Cell Carcinoma – Role of the Plasmniogen Activation System in Tumour Progression

2005-2008:         Lab technician, Medical Biochemistry Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway.

2004:                  Trainee at Biotec Pharmacon ASA, Tromsø, Norway

2003:                  6 months study abroad at Auckland University of Technology, New Zealand.

2000-2005:        Master of Science - Molecular Biotechnology, University of Tromsø, Norway.

Undervisning

2019-current:      Co-supervisor, 2 PhD-candidates, Tumour Biology Research Group

2019:                   Supervisor, 1 medical student, Valgfri fordypning 1 (MED-2501 Delemne 2.5 Del A)

2019:                   Internal supervisor for 1 Bachelor student abroad, Bachelor in Biomedicine (MBI-2010)

2019-2020:          Main supervisor, 2 Master students, Master of Science in Biomedicine (MBI-3911)

2018-2019:          Main supervisor, 1 Master student, Master of Science in Biomedicine (MBI-3911)

2018-2022:          Course leader, lecturer and sensor, The Biology of Cancer (MBI-3004)

2018:                   Sensor (written and oral exam), Molecular and Clinical Aspects of Cancer (MBI-8007)

2018:                   External sensor, Master of Science, NTNU (MOL3901)

2018-current:      Committee member, revising the Master in Biomedicine study program

2018-current:      Revising the MBI-3004 - The Biology of Cancer course for accreditation

2017-2018:          Group work supervisor and sensor, course Academic text analysis and academic writing (HEL-0700)

2017:                   Internal sensor for Bachelor student in Biomedicine (MBI-2010), UiT - The Arctic University of Norway

2016:                   Sensor, course Molecular and Clinical Aspects of Cancer, block I (BIO-8303)

2016-2017:          Group work supervisor, course Cell Biology (MED-1501)

2011:                   Lecturer, Research Communication (L8004)

2011:                   Group work supervisor, course Cell Biology (MED-100/ODO-1001)

2011:                   Co-supervisor, 1 master student, Master of Science in Biomedicine (MBI-3911)

2010:                   Lab assistant, course Advanced Methods for Experimental Biomedicine (MBI-3101)

2009-2010:          Lab leader, course Medical Biochemistry (BIO-3309)

2009-2011:          Group work supervisor, course Basic Chemistry (MED-100)

2008:                   Lab assistant, course Medical Biochemistry (BIO-3309)

2005-2007:          Lab assistant, course Basic Chemistry (MED-100)

Arbeider i CRIStin


  • Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S.. A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells. (fulltekst) Journal of Proteome Research 2019; Volum 18 (3). ISSN 1535-3893.s 1237 - 1247.s doi: 10.1021/acs.jproteome.8b00859.

  • Steigedal, Tonje S.; Toraskar, Jimita Prashant; Redvers, Richard P.; Valla, Marit; Magnussen, Synnøve; Bofin, Anna M.; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L.; Lamar, John Michael; Doherty, Judy; Hynes, Richard O.; Anderson, Robin L.; Svineng, Gunbjørg. Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. (fulltekst) Neoplasia 2018; Volum 20 (4). ISSN 1522-8002.s 387 - 400.s doi: 10.1016/j.neo.2018.02.008.

  • Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S.. Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif. FEBS Open Bio 2018; Volum 8 (12). ISSN 2211-5463.s 1992 - 2001.s doi: 10.1002/2211-5463.12544.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena; Berg, Eli; Cavalcanti Jacobsen, Cristiane de Albuquerque; Mortensen, Bente; Salo, Tuula; Martinez, Inigo Zubiavrre; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. BMC Cancer 2017; Volum 17. ISSN 1471-2407.s doi: 10.1186/s12885-017-3349-7.

  • Rikardsen, Oddveig G; Magnussen, Synnøve; Svineng, Gunbjørg; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson. Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma. BMC Oral Health 2015; Volum 15:98. ISSN 1472-6831.s doi: 10.1186/s12903-015-0084-9.

  • Magnussen, Synnøve; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Svineng, Gunbjørg. Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC). PLOS ONE 2014; Volum 9:e101895 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0101895.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes. PLOS ONE 2014; Volum 9:e0105929 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105929.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve. Plasmin and the plasminogen activator system in health and disease. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 261 - 290.

  • Ljones, Hilde; Hadler-Olsen, Elin Synnøve; Magnussen, Synnøve; Rikardsen, Oddveig G; Steigen, sonja eriksson; Sundkvist, elisabeth; Loennechen, Thrina; Kanapathippillai, Premasany; Kildalsen, hanne; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment. American Journal of Pathology 2011; Volum 178 (5). ISSN 0002-9440.s 2389 - 2396.s doi: 10.1016/j.ajpath.2011.01.022.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Anderson, Robin L.; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains. 21st International Symposium on Signal Transduction at the Blood-Brain Barriers 2018-09-19 - 2018-09-21 2018.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains. European Association for Cancer Research (EACR) Meeting 2017-11-27 - 2017-11-29 2017.

  • Magnussen, Synnøve. Et viktig puslespill.... Andøyposten 2017.

  • Magnussen, Synnøve; Wilhelm, Imola; Hasko, Janos; Molnar, Judith; Seppola, Marit; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. The metastasis-promoting protein Nephronectin. Regional Helseforskningskonferanse 2016-11-02 - 2016-11-03 2016.

  • Magnussen, Synnøve. The metastasis-promoting protein Nephronectin. Regional Helseforskningskonferanse 2016-11-02 - 2016-11-03 2016.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Jacobsen, Cristiane Cavalcanti; Berg, Eli; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal induced expression of uPAR. Matrix Metalloproteinases Crucial Components of Molecular Networks and Disease Pathways 2013-05-19 - 2013-05-24 2013.

  • Ravuri, Chandra Sekhar; Magnussen, Synnøve; Winberg, Jan-Olof; Huseby, Nils-Erik; Svineng, Gunbjørg. The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion. FEBS Advanced lecture Course, Matrix Pathobiology, Signaling and Molecular targets 2007-05-21 - 2007-05-26 2007.

  • Medlem i forskergruppe