gunbjørg svineng 1.jpg
Foto: Gry Berntzen

Flag icon Flag icon

Gunbjørg Svineng

Instituttleder
Institutt for medisinsk biologi

Stillingsbeskrivelse:

Instituttleder ved Institutt for medisinsk biologi (IMB).

Professor i tumorbiologisk forskningsgruppe.

https://orcid.org/0000-0002-5947-5647

 

 




Forskningsinteresser

Tumorbiology

Extracellular matrix degrading enzymes; uPAR and MMPs

Cell adhesion molecules; Integrins

Extracellular matrix proteins; Nephronectin

Metastasis related proteins; S100A4

CV

Konstituert instituttleder ved Institutt for medisinsk biologi, Det Helsevitenskapelige fakultet, 1.08.2017-31.12.2017. 

Forskningsopphold ved Sydney University, Charles Perkins Center or ANZAC Research Institute, Australia, 2016-2017.

Forskningsgruppeleder Tumorbiologisk forskningsgruppe, 2015-2016.

Forskningsopphold ved Peter MacCallum Cancer Centre, Melbourne, Australia, 2010-2011.

Undervisningsansvarlig IMB, 2009-2016.

Avdelingsleder Medisinsk biokjemi, IMB, 2006-2009. 

Førsteamanuensis i medisinsk biokjemi, IMB fra 2005. 

Forsker i Marin bioteknologi, Norges Fiskerihøyskole, 2004-2005.

Postdoc. i Molekylær kreftforskning, Biokjemisk avdeling, IMB, lønnet av Kreftforeningen, 2001-2004. Prosjekt: SPBP 

Doktorgrad i 1999 i Medicinsk Vetenskap fra Institutionen för Medicinsk Biokemi och Mikrobiologi, Medicinska fakultetet, Uppsala Universitet, Sverige.

Cand.scient i 1993 i Molekylærbiologi ved Biokjemisk avdeling, Institutt for Medisinsk Biologi, UiT.

Arbeider i CRIStin


  • Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S.. A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells. (fulltekst) Journal of Proteome Research 2019; Volum 18 (3). ISSN 1535-3893.s 1237 - 1247.s doi: 10.1021/acs.jproteome.8b00859.

  • Steigedal, Tonje S.; Toraskar, Jimita Prashant; Redvers, Richard P.; Valla, Marit; Magnussen, Synnøve; Bofin, Anna M.; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L.; Lamar, John Michael; Doherty, Judy; Hynes, Richard O.; Anderson, Robin L.; Svineng, Gunbjørg. Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. (fulltekst) Neoplasia 2018; Volum 20 (4). ISSN 1522-8002.s 387 - 400.s doi: 10.1016/j.neo.2018.02.008.

  • Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S.. Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif. FEBS Open Bio 2018; Volum 8 (12). ISSN 2211-5463.s 1992 - 2001.s doi: 10.1002/2211-5463.12544.

  • Sylte, Ingebrigt; Dawadi, Rangita; Malla, Nabin; von Hofsten, Susannah; Nguyen, Tra-Mi; Solli, Ann Iren; Berg, Eli; Adekoya, Olayiwola; Svineng, Gunbjørg; Winberg, Jan-Olof. The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases. PLOS ONE 2018; Volum 13 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0200237.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena; Berg, Eli; Cavalcanti Jacobsen, Cristiane de Albuquerque; Mortensen, Bente; Salo, Tuula; Martinez, Inigo Zubiavrre; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. BMC Cancer 2017; Volum 17. ISSN 1471-2407.s doi: 10.1186/s12885-017-3349-7.

  • Åström, Pirjo; Juurikka, Krista; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Cervigne, Nilva K.; Coletta, Ricardo D.; Risteli, Juha; Kauppila, Joonas H.; Skarp, Sini; Kuttner, Samuel; Oteiza, Ana; Sutinen, Meeri; Salo, Tuula. The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. British Journal of Cancer 2017; Volum 117 (7). ISSN 0007-0920.s 1007 - 1016.s doi: 10.1038/bjc.2017.249.

  • Rikardsen, Oddveig G; Magnussen, Synnøve; Svineng, Gunbjørg; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson. Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma. BMC Oral Health 2015; Volum 15:98. ISSN 1472-6831.s doi: 10.1186/s12903-015-0084-9.

  • Magnussen, Synnøve; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Svineng, Gunbjørg. Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC). PLOS ONE 2014; Volum 9:e101895 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0101895.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes. PLOS ONE 2014; Volum 9:e0105929 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105929.

  • Ravuri, Chandra Sekhar; Svineng, Gunbjørg; Huseby, nils-erik. Differential regulation of gamma-glutamyltransferase and glutamate cysteine ligase expression after mitochondrial uncoupling: gamma-glutamyltransferase is regulated in an Nrf2- and NF kappa B-independent manner. Free radical research 2013; Volum 47 (5). ISSN 1071-5762.s 394 - 403.s doi: 10.3109/10715762.2013.781270.

  • Malla, Nabin; Berg, Eli; Theocharis, Achilleas D.; Svineng, Gunbjørg; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican. The FEBS Journal 2013; Volum 280 (12). ISSN 1742-464X.s 2870 - 2887.s doi: 10.1111/febs.12291.

  • Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.

  • Fadnes, Bodil Irene; Husebekk, Anne; Svineng, Gunbjørg; Rekdal, Øystein; Yanagishita, Masaki; Kolset, Svein Olav; Uhlin-Hansen, Lars. The proteoglycan repertoire of lymphoid cells. Glycoconjugate Journal 2012; Volum 29 (7). ISSN 0282-0080.s 513 - 523.s doi: 10.1007/s10719-012-9427-9.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve. Plasmin and the plasminogen activator system in health and disease. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 261 - 290.

  • Ravuri, Chandra Sekhar; Svineng, Gunbjørg; Pankiv, Serhiy; Huseby, nils-erik. Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of gamma gamma-glutamyltransferase expression. Free radical research 2011; Volum 45 (5). ISSN 1071-5762.s 600 - 610.s doi: 10.3109/10715762.2011.564164.

  • Ljones, Hilde; Hadler-Olsen, Elin Synnøve; Magnussen, Synnøve; Rikardsen, Oddveig G; Steigen, sonja eriksson; Sundkvist, elisabeth; Loennechen, Thrina; Kanapathippillai, Premasany; Kildalsen, hanne; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment. American Journal of Pathology 2011; Volum 178 (5). ISSN 0002-9440.s 2389 - 2396.s doi: 10.1016/j.ajpath.2011.01.022.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Ravuri, Chandra Sekhar; Omair, Ahmad; Rikardsen, Oddveig G; Svineng, Gunbjørg; Kanapathippillai, Premasany; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front. European Journal of Cancer 2011; Volum 47 (2). ISSN 0959-8049.s 305 - 315.s doi: 10.1016/j.ejca.2010.09.006.

  • Hadler-Olsen, Elin Synnøve; Kanapathippillai, Premasany; Berg, Eli; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity. Journal of Histochemistry and Cytochemistry 2010; Volum 58 (1). ISSN 0022-1554.s 29 - 39.s doi: 10.1369/jhc.2009.954354.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Kanapathippillai, Premasany; Grenman, Reidar; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Archiv 2010; Volum 457 (6). ISSN 0945-6317.s 677 - 692.s doi: 10.1007/s00428-010-0980-y.

  • Huseby, nils-erik; Sundkvist, elisabeth; Svineng, Gunbjørg. Glutathione and Sulfur Containing Amino Acids: Antioxidant and Conjugation Activities. John Wiley & Sons 2009 ISBN 978-0-470-17085-4.s 93 - 120.

  • Larsen, Atle Noralf; Solstad, Terese; Svineng, Gunbjørg; Seppola, Marit; Jørgensen, Trond Ø.. Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.). Fish and Shellfish Immunology 2009; Volum 26 (1). ISSN 1050-4648.s 122 - 132.s doi: 10.1016/j.fsi.2008.03.021.

  • Elenjord, Renate; Allen, Jasmine Blue; Johansen, Harald Thidemann; Johansen, Harald T.; Kildalsen, hanne; Svineng, Gunbjørg; Mælandsmo, Gunhild; Loennechen, Thrina; Winberg, Jan-Olof. Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. The FEBS Journal 2009; Volum 276 (18). ISSN 1742-464X.s 5275 - 5286.s doi: 10.1111/j.1742-4658.2009.07223.x.

  • Svineng, Gunbjørg; Ravuri, Chandra Sekhar; Rikardsen, Oddveig G; Huseby, Nils-Erik; Winberg, Jan-Olof. The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connective Tissue Research 2008; Volum 49. ISSN 0300-8207.s 197 - 202.s doi: 10.1080/03008200802143166.

  • Sjøttem, Eva; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia sagen; Klenow, Helle Bagterp; Uglehus, Rebecca dale; Johansen, Terje. The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. Nucleic Acids Research 2007; Volum 35 (19). ISSN 0305-1048.s 6648 - 6662.s doi: 10.1093/nar/gkm739.

  • Politz, Oliver; Gratchev, Alexei; McCourt, Peter Anthony; Schledzewski, Kai; Guillot, Pierre; Johansson, Sophie; Svineng, Gunbjørg; Franke, Paul; Kannicht, Catherine; Welten, Florian; Johansson, Staffan; Goerdt, Sergej. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochemical Journal 2002; Volum 362. ISSN 0264-6021.s 155 - 164.

  • Anderssen, Sølvi; Sjøttem, Eva; Svineng, Gunbjørg; Johansen, Terje. Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like ELements Isolated from Marmoset, African Green Monkey, and Man. Virology 1997; Volum 234. ISSN 0042-6822.s 14 - 30.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Anderson, Robin L.; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains. 21st International Symposium on Signal Transduction at the Blood-Brain Barriers 2018-09-19 - 2018-09-21 2018.

  • Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judith; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. Nephronectin (Npnt) promotes breast cancer brain metastasis via its integrin binding domains. European Association for Cancer Research (EACR) Meeting 2017-11-27 - 2017-11-29 2017.

  • Magnussen, Synnøve; Wilhelm, Imola; Hasko, Janos; Molnar, Judith; Seppola, Marit; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg. The metastasis-promoting protein Nephronectin. Regional Helseforskningskonferanse 2016-11-02 - 2016-11-03 2016.

  • Svineng, Gunbjørg; Larsen, Terje Steinar. Bli ekspert på menneskekroppen og få en trygg og viktig jobb!. 2015.

  • Wirsing, Anna Maria; Solli, Ann Iren; Svineng, Gunbjørg; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve. Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -. The 7th National PhD Conference in Medical Imaging 2015-11-16 - 2015-11-17 2015.

  • Wirsing, Anna Maria; Solli, Ann Iren; Svineng, Gunbjørg; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve. Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress. Gordon Research Conference on Matrix Metalloproteinases 2015-08-02 - 2015-08-07 2015.

  • Steigedal, Tonje Strømmen; Redvers, Richard; Eckhardt, Bedrich; Lamar, John Michael; Doherty, Judy; Hynes, Richard O.; Anderson, Robin; Svineng, Gunbjørg. The extracellular matrix protein Nephronectin (Npnt) promotes metastasis via its integrin binding domains. The 15th biennial Metastasis Research Congress 2014-06-28 - 2014-07-01 2014.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Jacobsen, Cristiane Cavalcanti; Berg, Eli; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal induced expression of uPAR. Matrix Metalloproteinases Crucial Components of Molecular Networks and Disease Pathways 2013-05-19 - 2013-05-24 2013.

  • Steigedal, Tonje; Svineng, Gunbjørg; Redvers, Richard; Eckhardt, Bedrich; Lamar, John M.; Doherty, Judy; Hynes, Richard O.; Anderson, Robin. Cellular interactions with the extracellular matrix of tumor microenvironment. Ingrid S. Gribbestad Memorial 2013-09-11 - 2013-09-13 2013.

  • Redvers, Richard; Svineng, Gunbjørg; Eckhardt, Bedrich; Pouliot, Normand; Stanley, Keith; Reichardt, Louis; Adams, Tim; Smith, Yvonne; Anderson, Robin. The role of the extracellular matrix molecule Nephronectin/POEM in breast cancer metastasis. Lorne Cancer Conference 2011-02-10 - 2011-02-12 2011.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Wetting, Hilde Ljones; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front. FEBS Advanced Lecture Course 2011matrix Pathobiology, Signalling and Molecular Targets 2011-09-02 - 2011-09-07 2011.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, O; Steigen, sonja eriksson; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2010; Volum 118 (3). ISSN 0903-4641.s 245 - 245.

  • Sjøli, Stian; Adekoya, Olayiwola; Jiang, Yang; Akselsen, O; Hansen, VT; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof. Novel Inhibitors of Matrix Metalloprotease-9 and-14. The FEBS Journal 2010; Volum 277. ISSN 1742-464X.s 265 - 265.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-hansen, lars. Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front. European Journal of Cancer 2010. ISSN 0959-8049.s doi: 10.1111/j.1600-0463.2009.02578.x.

  • Ravuri, Chandra Sekhar; Magnussen, Synnøve; Winberg, Jan-Olof; Huseby, Nils-Erik; Svineng, Gunbjørg. The effect of elevated levels of reactive oxygen species on oral squamous carcinoma cell adhesion and invasion. FEBS Advanced lecture Course, Matrix Pathobiology, Signaling and Molecular targets 2007-05-21 - 2007-05-26 2007.

  • Larsen, Atle Noralf; Helland, Ronny; Svineng, Gunbjørg; Jørgensen, Trond Ø.. Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua). The 7th Nordic symposium on Fish Immunology 2007-06-18 - 2007-06-22 2007.

  • Sjøttem, Eva; Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Johnsen, Sylvia Sagen; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1: Modulators of Androgen Receptor Activity. 7th EMBL Transcription Meeting 2006-08-26 - 2006-08-30 2006.

  • Klenow, Helle Bagterp; Rekdal, Cecilie; Svineng, Gunbjørg; Sjøttem, Eva; Uglehus, Rebecca Dale; Johansen, Terje. SPBP and TopBP1 interact to enhance Ets-mediated activation of the c-myc promoter. Lorne meeting 2006-02-10 - 2006.

  • Svineng, Gunbjørg. Genetic modifications of oral cancer cell lines. Annual meeting for the Tumor Biology Research Group 2006-11-14 - 2006-11-15 2006.

  • Medlem i forskergruppe