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Osman Gani

Forsker
Kjemi

Stillingsbeskrivelse:

Forsker i strukturkjemi




Forskningsinteresser

Data mining & machine learning: Large scale mining of structural and bioactivity data from open source databases for understanding modulation of macromolecules involved in human health. Data driven statistical models by using machine learning methods.

Visualization: Programming and presentation of data driven information succinctly.

Computer-aided drug design: Use of virtual screening, scoring and MD simulations of small
molecules in complex with their targets for assessing ligandability.

Forskningsprosjekter

Multitargeted protein kinase inhibitor design. Study of selectivity determinants of
ATP-dependent proteins

Biografiske data

PhD (2007) i Faramaklogi: Det helsevitenskapelige fakultet,, UiT Norges Arktiske Universitetet

Bachelor (1995) og Master (1997) i Farmasi : University of Dhaka 

Lektor: Avdeling av Farmasi (2001-2002):  Khulna University

Postdoc (2008-2009): Det helsevitenskapelige fakultet, UiT Norges Arktiske Universitetet

Undervisning

KJE8704--Structure Guided Drug Design

Arbeider i CRIStin


  • Gani, Osman A.B.S.M.; Thakkar, Balmukund; Narayanan, Dilip; Alam, Kazi Asraful; Kyomuhendo, Peter; Rothweiler, Ulli; Tello-Franco, Veronica; Engh, Richard Alan. Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches. Biochimica et Biophysica Acta - Proteins and Proteomics 2015; Volum 1854 (10). ISSN 1570-9639.s 1605 - 1616.s doi: 10.1016/j.bbapap.2015.05.004.

  • Gani, Osman A.B.S.M.; Narayanan, Dilip; Engh, Richard Alan. Evaluating the Predictivity of Virtual Screening for Abl Kinase Inhibitors to Hinder Drug Resistance. Chemical Biology and Drug Design 2013; Volum 82 (5). ISSN 1747-0277.s 506 - 519.s doi: 10.1111/cbdd.12170.

  • Åberg, espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli; Oliveira, Taiana Maia De; Engh, Richard Alan. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry (Print) 2012; Volum 393 (10). ISSN 1431-6730.s 1121 - 1129.s doi: 10.1515/hsz-2012-0248.

  • Odlo, Kristin; Fournier-Dit-Chabert, Jérémie; Ducki, Sylvie; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Hansen, Trond Vidar. 1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents. Bioorganic & Medicinal Chemistry 2010; Volum 18 (18). ISSN 0968-0896.s 6874 - 6885.s doi: 10.1016/j.bmc.2010.07.032.

  • Gani, Osman A.B.S.M.; Engh, Richard Alan. Protein kinase inhibition of clinically important staurosporine analogues. Natural product reports (Print) 2010; Volum 27 (4). ISSN 0265-0568.s 489 - 498.s doi: 10.1039/b923848b.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor alpha. Medicinal Chemistry Research 2009; Volum 18 (1). ISSN 1054-2523.s 8 - 19.s doi: 10.1007/s00044-008-9102-7.

  • Gani, Osman A.B.S.M.. Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?. Cardiovascular Diabetology 2008; Volum 7. ISSN 1475-2840.s doi: 10.1186/1475-2840-7-6.

  • Gani, Osman A.B.S.M.; Adekoya, Olayiwola; Giurato, L; Spyrakis, F; Cozzini, P; Guccione, S; Winberg, Jan-Olof; Sylte, Ingebrigt. Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases. Biophysical Journal 2008; Volum 94. ISSN 0006-3495.s doi: 10.1529/biophysj.107.111096.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma. Chemical Biology and Drug Design 2008; Volum 72. ISSN 1747-0277.s 50 - 57.s doi: 10.1111/j.1747-0285.2008.00677.x.

  • Odlo, K; Hentzen, J; dit Chabert, JF; Ducki, S; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Skrede, M; Flørenes, Vivi Ann; Florenes, VA; Hansen, TV. 1,5-disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin. Bioorganic & Medicinal Chemistry 2008; Volum 16. ISSN 0968-0896.s 4829 - 4838.s doi: 10.1016/j.bmc.2008.03.049.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. Journal of Molecular Graphics and Modelling 2008; Volum 27. ISSN 1093-3263.s 217 - 224.s doi: 10.1016/j.jmgm.2008.04.008.

  • Gani, Osman A.B.S.M.. Signposts of docking and scoring in drug design. Chemical Biology and Drug Design 2007; Volum 70. ISSN 1747-0277.s 360 - 365.s doi: 10.1111/j.1747-0285.2007.00571.x.

  • Thakkar, Balmukund; Gani, Osman; Engh, Richard Alan. Practical Applications of Informatics Tools to Identify Drug Targets for Novel Compounds from Bio- and Chemoprospecting. 52nd NBS contact meeting 2016-01-21 - 2016-01-24 2016.

  • Boomgaren, Marc; Gani, Osman; Engh, Richard Alan; Hansen, Jørn H. Bioactive Heterocycle Libraries for Anticancer Drug Discovery - Development of Covalent Binding TK Inhibitors. Organikerdagarna 2016-06-14 - 2016-06-17 2016.

  • Boomgaren, Marc; Gani, Osman A.B.S.M.; Engh, Richard Alan; Hansen, Jørn H. Bioactive Heterocycle Libraries for Anticancer Drug Discovery. BioStruct/Molecular and Clinical Cancer Research School Open Day 2015-03-20 - 2015.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. The effect of E-Z isomerization of docosahexaeonic acid (DHA) double bonds on binding to nuclear receptors. Docking and scoring in structure guided drug design. 2006-04-05 - 2006-04-07 2006.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of fatty acids by PPAR-alpha. Structure-based Drug Design 2006-06-14 - 2006-06-16 2006.

  • Adekoya, Olayiwola Adedotun; Dahl, Svein G.; Gabrielsen, Mari; Gani, Osman A.B.S.M.; Khan, Mahmud Tareq Hassan; Kristiansen, kurt; Sylte, Ingebrigt; Ravna, aina westrheim; Wuxiuer, Y; Sandberg, LS. The molecular modelling group. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.

  • Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of fatty acids by PPAR-alpha. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.

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