Forskningsinteresser

Struktur og funksjon av G-proteinkoblede reseptorer
Studier av legemidler og deres interaksjoner med membranproteiner.

CV

Utdanning

1992    Cand. Scient., University of Tromsø
1997     Dr. Scient., University of Tromsø

Yrkespraksis

1997-1998    Postdoctoral fellowship, Case Western University, Cleveland, Ohio, U.S.
1998-1999    Postdoctoral fellowship from Forskerakademiet in Denmark, Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
1999-2000    Postdoctoral fellowship, Institute of Medical Pharmacology, Berlin, Germany
2000-2006    Postdoctoral fellowship, Research council of Norway and Functional Genomics in northern Norway, University of Tromsø
2006-Present  Associate Professor in Pharmacology, University of Tromsø

Arbeider i CRIStin


  • Evenseth, Linn; Kristiansen, kurt; Song, You; Tollefsen, Knut-Erik; Sylte, Ingebrigt. In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology 2019; Volum 12:100091. ISSN 2468-1113.s 1 - 11.s doi: 10.1016/j.comtox.2019.100091.

  • Doering, Jon A.; Lee, Sehan; Kristiansen, kurt; Evenseth, Linn; Sylte, Ingebrigt; Barron, Mace G.; Lalone, Carlie. In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool. Toxicological Sciences 2018; Volum 166 (1). ISSN 1096-6080.s 131 - 145.s doi: 10.1093/toxsci/kfy186.

  • Warszycki, Dawid; Rueda, Manuel; Mordalski, Stefan; Kristiansen, kurt; Satala, Grzegorz; Rataj, Krzysztof; Chilmonczyk, Zdzislaw; Sylte, Ingebrigt; Abagyan, Ruben; Bojarski, Andrzej J. From Homology Models to a Set of Predictive Binding Pockets-a 5-HT<sub>1A</sub> Receptor Case Study. Journal of chemical information and computer sciences 2017; Volum 57 (2). ISSN 0095-2338.s 311 - 321.s doi: 10.1021/acs.jcim.6b00263.

  • Routti, Heli Anna Irmeli; Lille-Langøy, Roger; Berg, Mari Katrine; Fink, Trine; Harju, Mikael; Kristiansen, Kurt; Rostkowski, Pawel Marian; Rusten, Marte; Sylte, Ingebrigt; Øygarden, Lene Eidsvik; Goksøyr, Anders. Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro. Environmental Science and Technology 2016; Volum 50 (19). ISSN 0013-936X.s 10708 - 10720.s doi: 10.1021/acs.est.6b03020.

  • Gabrielsen, Mari; Kurczab, Rafal; Siwek, Agata; Wolak, Malgorzata; Ravna, Aina Westrheim; Kristiansen, kurt; Kufareva, Irina; Abagyan, Ruben; Nowak, Gabriel; Chilmonczyk, Zdzislaw; Sylte, Ingebrigt; Bojarski, Andrzej J.. Identification of novel serotonin transporter compounds by virtual Screening. Journal of Chemical Information and Modeling 2014; Volum 54 (3). ISSN 1549-9596.s 933 - 943.s doi: 10.1021/ci400742s.

  • Kufareva, Irina; Katritch, Vsevolod; Freyd, Thibaud; Gabrielsen, Mari; Kristiansen, kurt; Sylte, Ingebrigt; Stevens, Raymond C.; Abagyan, Ruben. Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: Meeting new challenges. Structure 2014; Volum 22 (8). ISSN 0969-2126.s 1120 - 1139.s doi: 10.1016/j.str.2014.06.012.

  • Larsen, Anett Kristin; Kristiansen, kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit. Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. BMC Research Notes 2013; Volum 6. ISSN 1756-0500.s 281 - .s doi: 10.1186/1756-0500-6-281.

  • Warszycki, Dawid; Mordalski, Stefan; Kristiansen, kurt; Kafel, Rafal; Sylte, Ingebrigt; Chilmonczyk, Zdzislaw; Bojarski, Andrzej J.. A Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New Active Compounds - An Application for 5-HT1A Receptor Ligands. PLOS ONE 2013; Volum 8 (12). ISSN 1932-6203.s doi: 10.1371/journal.pone.0084510.

  • Gabrielsen, Mari; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations. Journal of Molecular Modeling 2012; Volum 18 (3). ISSN 1610-2940.s 1073 - 1085.s doi: 10.1007/s00894-011-1133-1.

  • Mordalski, Stefan; Kosciolek, Tomasz; Kristiansen, kurt; Sylte, Ingebrigt; Bojarski, Andrezej J. Protein binding site analysis by means of structural interaction fingerprint patterns. Bioorganic & Medicinal Chemistry Letters 2011; Volum 21 (22). ISSN 0960-894X.s 6816 - 6819.s doi: 10.1016/j.bmcl.2011.09.027.

  • Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Nowak, Gabriel; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & Medicinal Chemistry 2008; Volum 16 (20). ISSN 0968-0896.s 9283 - 9294.s doi: 10.1016/j.bmc.2008.09.005.

  • Ravna, Aina Westrheim; Sylte, Ingebrigt; Kristiansen, Kurt; Dahl, Svein G.. Putative drug binding conformations of monoamine transporters. Bioorganic & Medicinal Chemistry 2006; Volum 14. ISSN 0968-0896.

  • Knutsen, HK; Ølstørn, HB; Paulsen, JE; Husøy, T; Goverud, Ingeborg Løstegaard; Løberg, Else Marit; Kristiansen, K; Alexander, J. Increased levels of PPARbeta/delta and cylin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. Anticancer Research 2005 (25). ISSN 0250-7005.s 3781 - 3789.

  • Paasche, J.D.; Attramadal, T.; Kristiansen, Kurt; Oksvold, M.P.; Johansen, H.K.; Huitfeldt, H.S.; Dahl, Svein G.; Attramadal, H.. Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors. Molecular Pharmacology 2005; Volum 67. ISSN 0026-895X.s 1581 - 1590.

  • Bruun, Jack-Ansgar; Thomassen, Ernst I.s.; Kristiansen, Kurt; Tylden, Garth Daryl; Holm, Turid; Mikkola, Ingvild; Bjørkøy, Geir; Johansen, Terje. The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Research 2005; Volum 33. ISSN 0305-1048.

  • Kristiansen, Kurt. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacology and Therapeutics 2004; Volum 103. ISSN 0163-7258.s 21 - 80.

  • Petersen, Rasmus K.; Petersen, RK; Jørgensen, Claus; Rustan, Arild C.; Jorgensen, C; Frøyland, Livar; Muller-Decker, Karin; Froyland, L; Furstenberger, Gerhard; Muller-Decker, K; Furstenberger, G; Berge, Rolf Kristian; Kristiansen, Karsten; Madsen, Lise; Kristiansen, K; Madsen, L. Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases. Journal of Lipid Research 2003; Volum 44. ISSN 0022-2275.s 2320 - 2330.

  • Nielsen, Kaare Magne; Kristiansen, Kurt. Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Molecular biology and evolution 2003; Volum 20. ISSN 0737-4038.s 726 - 734.

  • Lamark, Trond; Perander, maria; Outzen, Heidi; Kristiansen, kurt; Øvervatn, Aud Karin; Michaelsen, Espen; Bjørkøy, Geir; Johansen, Terje. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.. (fulltekst) Journal of Biological Chemistry 2003; Volum 10 (278(36)). ISSN 0021-9258.s 34568 - 34581.s doi: 10.1074/jbc.M303221200.

  • Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Dybala, M; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Molecular mechanism of selective serotonin reuptake inhibitors (SSRI's)interactions with serotonin transporter. 29th European Peptide Symposium 2006-09-03 - 2006-09-08 2006.

  • Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Dybala, M; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Molecular mechanism of selective serotonin reuptake inhibitors (SSRI's) interactions with serotonin transporter. Journal of Peptide Science 2006; Volum 12. ISSN 1075-2617.s 186 - 186.

  • Adekoya, Olayiwola Adedotun; Dahl, Svein G.; Gabrielsen, Mari; Gani, Osman A.B.S.M.; Khan, Mahmud Tareq Hassan; Kristiansen, kurt; Sylte, Ingebrigt; Ravna, aina westrheim; Wuxiuer, Y; Sandberg, LS. The molecular modelling group. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.

  • Paasche, J.D.; Attramadal, T.; Kristiansen, Kurt; Johansen, H.K.; Dahl, Svein G.; Attramadal, Håvard. Structural characterization of a motif that dictates recycling of the ETA receptor via a novel molecular mechanism. Circulation 2003; Volum 108. ISSN 0009-7322.s 206 - 206.