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Lars Uhlin-Hansen

Professor
Institutt for medisinsk biologi

Stillingsbeskrivelse:

Lars Uhlin-Hansen er professor i rettsmedisin og patologi.




Forskningsinteresser

Kreft, med hovedfokus på munnhulekreft.

CV

Lars Uhlin-Hansen er professor i rettsmedisin og patologi. Han har bred rettsmedisinsk erfaring fra inn- og utland, og har i over 20 år regelmessig blitt benyttet som rettsmedisinsk sakkyndig i straffesaker i hele landet. Han har også hatt oppdrag for Den internasjonale straffedomstolen i Haag. Han er medlem av den nasjonale ID-gruppen og har deltatt i en rekke operasjoner nasjonalt og internasjonalt. Han er medlem av Den rettsmedisinske kommisjon, og er leder for Rettsgenetisk senter ved UiT. Hans forskningsaktivitet har i hovedsak vært kreftrelatert og de siste årene har han spesielt fokusert på munnhulekreft. Han er leder for Norwegian Oral Cancer (NOROC) studien, en tverrfaglig studie på munnhulekreft hvor alle universitetssykehusene i Norge er involvert. Uhlin-Hansen har bistilling som overlege på avdeling for Klinisk patologi, Universitetssykehuset Nord-Norge hvor han blant annet har et ansvar for diagnostikk av lymfeknutekreft (lymfom).


Utdanning
1982: Cand.med. (MD), Universitetet i Tromsø
1990: Dr. med. (PhD), Universitetet i Tromsø
2003: Spesialist i patologi.

Yrkespraksis
1985-1987: Stipendiat, Institutt for medisinsk biologi, UiT
1987-2006: Amanuensis/førsteamanuensis, Institutt for medisinsk biologi
1991-1992: Visiting scientist, National Institutes of Health, Bethesda, USA
1996-2001: Assistentlege, Patologisk anatomisk avdeling, UNN
1997-1998: Visiting scientist, US Food and Drug Administration, Bethesda, USA
2001-d.d.: Overlege, Patologisk anatomisk avdeling/Klinisk patologi, UNN
2003: Visiting pathologist, Hotel Dieu, Paris
2004: Visiting pathologist, Medical examiners department, Miami
2006-d.d.: Professor i rettsmedisin og patologi, Institutt for medisinsk biologi, UiT
2010-2011: Visiting scientist, Retsmedicinsk institut, Københavns universitet1

Undervisning

Underviser i anatomi, patologi og rettsmedisin.

Arbeider i CRIStin


  • Wirsing, Anna Maria; Ervik, Ida Korsnes; Seppola, Marit; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Hadler-Olsen, Elin Synnøve. Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma. Modern Pathology 2018; Volum 31. ISSN 0893-3952.s 910 - 922.s doi: 10.1038/s41379-018-0019-5.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Costea, Daniela Elena; Berg, Eli; Cavalcanti Jacobsen, Cristiane de Albuquerque; Mortensen, Bente; Salo, Tuula; Martinez, Inigo Zubiavrre; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion. BMC Cancer 2017; Volum 17. ISSN 1471-2407.s doi: 10.1186/s12885-017-3349-7.

  • Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers. Journal of Cellular Physiology 2015; Volum 230 (1). ISSN 0021-9541.s 160 - 169.s doi: 10.1002/jcp.24694.

  • Skjölsvik, Eystein; Steensrud, Tor; Dahl-Eriksen, Øystein; Uhlin-Hansen, Lars; Lunde, Per. Cardiac Perforation Caused by Cement Embolus After Total Hip Replacement. Circulation 2015; Volum 132. ISSN 0009-7322.s 1047 - 1048.s doi: 10.1161/CIRCULATIONAHA.115.017141.

  • Rikardsen, Oddveig G; Magnussen, Synnøve; Svineng, Gunbjørg; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson. Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma. BMC Oral Health 2015; Volum 15:98. ISSN 1472-6831.s doi: 10.1186/s12903-015-0084-9.

  • Wirsing, Anna Maria; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve. Presence of tumour high-endothelial venules is an independent positive prognostic factor and stratifies patients with advanced-stage oral squamous cell carcinoma. Tumour Biology 2015; Volum Published ahead of print. ISSN 1010-4283.s doi: 10.1007/s13277-015-4036-4.

  • Pirilä, Emma; Väyrynen, Otto; Sundquist, Elias; Päkkilä, Kaisa; Nyberg, Pia; Nurmenniemi, Sini; Pääkkönen, Virve; Pesonen, Paula; Dayan, Dan; Vered, Marilena; Uhlin-Hansen, Lars; Salo, Tuula. Macrophages modulate migration and invasion of human tongue squamous cell carcinoma. PLOS ONE 2015; Volum 10 (3). ISSN 1932-6203.s doi: 10.1371/journal.pone.0120895.

  • Magnussen, Synnøve; Rikardsen, Oddveig G; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson; Svineng, Gunbjørg. Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC). PLOS ONE 2014; Volum 9:e101895 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0101895.

  • Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes. PLOS ONE 2014; Volum 9:e0105929 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0105929.

  • Wirsing, Anna; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve. Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma. BMC Clinical Pathology 2014; Volum 14:38. ISSN 1472-6890.s doi: 10.1186/1472-6890-14-38.

  • Rikardsen, Oddveig G; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson. Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study. BMC Oral Health 2014; Volum 14:103. ISSN 1472-6831.s doi: 10.1186/1472-6831-14-103.

  • Malla, Nabin; Berg, Eli; Theocharis, Achilleas D.; Svineng, Gunbjørg; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican. The FEBS Journal 2013; Volum 280 (12). ISSN 1742-464X.s 2870 - 2887.s doi: 10.1111/febs.12291.

  • Hadler-Olsen, Elin Synnøve; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biology 2013; Volum 34 (4). ISSN 1010-4283.s 2041 - 2051.s doi: 10.1007/s13277-013-0842-8.

  • Solli, Ann Iren; Fadnes, Bodil Irene; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve. Tissue- and Cell-Specific Co-localization of Intracellular Gelatinolytic Activity and Matrix Metalloproteinase 2. Journal of Histochemistry and Cytochemistry 2013; Volum 61 (6). ISSN 0022-1554.s 444 - 461.s doi: 10.1369/0022155413484765.

  • Fadnes, Bodil Irene; Husebekk, Anne; Svineng, Gunbjørg; Rekdal, Øystein; Yanagishita, Masaki; Kolset, Svein Olav; Uhlin-Hansen, Lars. The proteoglycan repertoire of lymphoid cells. Glycoconjugate Journal 2012; Volum 29 (7). ISSN 0282-0080.s 513 - 523.s doi: 10.1007/s10719-012-9427-9.

  • Fadnes, Bodil Irene; Hadler-Olsen, Elin Synnøve; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Matrix metalloproteinase complexes and their biological significance. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 291 - 314.

  • Hadler-Olsen, Elin Synnøve; Fadnes, Bodil Irene; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Regulation of matrix metalloproteinase activity in health and disease. The FEBS Journal 2011; Volum 278 (1). ISSN 1742-464X.s 28 - 45.s doi: 10.1111/j.1742-4658.2010.07920.x.

  • Ljones, Hilde; Hadler-Olsen, Elin Synnøve; Magnussen, Synnøve; Rikardsen, Oddveig G; Steigen, sonja eriksson; Sundkvist, elisabeth; Loennechen, Thrina; Kanapathippillai, Premasany; Kildalsen, hanne; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment. American Journal of Pathology 2011; Volum 178 (5). ISSN 0002-9440.s 2389 - 2396.s doi: 10.1016/j.ajpath.2011.01.022.

  • Hadler-Olsen, Elin Synnøve; Winberg, Jan-Olof; Reinholt, Finn P.; Larsen, Terje; Uhlin-Hansen, Lars; Jenssen, Trond Geir; Berg, Eli; Kolset, Svein Olav. Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy. ISRN Endocrinology 2011. ISSN 2090-4630.s doi: 10.5402/2011/832642.

  • Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Lindin, Inger; Rekdal, Øystein. Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells. BMC Cancer 2011; Volum 11. ISSN 1471-2407.s doi: 10.1186/1471-2407-11-116.

  • Malla, Nabin; Berg, Eli; Moens, Ugo; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway. PLOS ONE 2011; Volum 6 (6). ISSN 1932-6203.s doi: 10.1371/journal.pone.0020616.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Ravuri, Chandra Sekhar; Omair, Ahmad; Rikardsen, Oddveig G; Svineng, Gunbjørg; Kanapathippillai, Premasany; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front. European Journal of Cancer 2011; Volum 47 (2). ISSN 0959-8049.s 305 - 315.s doi: 10.1016/j.ejca.2010.09.006.

  • Hadler-Olsen, Elin Synnøve; Kanapathippillai, Premasany; Berg, Eli; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity. Journal of Histochemistry and Cytochemistry 2010; Volum 58 (1). ISSN 0022-1554.s 29 - 39.s doi: 10.1369/jhc.2009.954354.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Kanapathippillai, Premasany; Grenman, Reidar; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Archiv 2010; Volum 457 (6). ISSN 0945-6317.s 677 - 692.s doi: 10.1007/s00428-010-0980-y.

  • Fadnes, Bodil Irene; Rekdal, Øystein; Uhlin-hansen, lars. The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells. BMC Cancer 2009; Volum 9. ISSN 1471-2407.s doi: 10.1186/1471-2407-9-183.

  • Malla, Nabin; Berg, Eli; Uhlin-hansen, lars; Winberg, Jan-Olof. Interaction of pro-matrix metalloproteinase-9/proteoglycan heteromer with gelatin and collagen. Journal of Biological Chemistry 2008; Volum 283. ISSN 0021-9258.s doi: 10.1074/jbc.M709140200.

  • Malla, Nabin; Sjøli, Stian; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve; Uhlin-hansen, lars. Biological and pathobiological functions of gelatinase dimers and complexes. Connective Tissue Research 2008; Volum 49. ISSN 0300-8207.s 180 - 184.s doi: 10.1080/03008200802151755.

  • Hansen, Berit; Øynebråten, Inger; Uhlin-Hansen, Lars; Smedsrød, Bård. Endocytosis and degradation of serglycin in liver sinusoidal endothelial cells. Molecular and Cellular Biochemistry 2006; Volum 287. ISSN 0300-8177.s 43 - 52.

  • Jenssen, Håvard; Andersen, Jeanette Hammer; Uhlin-Hansen, Lars; Gutteberg, Tore Jarl; Rekdal, Øystein. Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate. Antiviral Research 2004; Volum 61. ISSN 0166-3542.s 101 - 109.

  • Winberg, Jan-Olof; Berg, Eli; Kolset, S O; Uhlin-Hansen, Lars. Calcium- induced activation and truncation of promatrix metalloproteinase-9 covalently linked to the core protein of chondroitin sulfate proteoglycans. European Journal of Biochemistry (EJB) 2003; Volum 270. ISSN 0014-2956.s 3996 - 4007.

  • Pejler, G; Winberg, Jan-Olof; Vuong, TT; Henningsson, F; Uhlin-Hansen, Lars; Kimata, K; Kolset, S O. Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans. European Journal of Biochemistry (EJB) 2003; Volum 270. ISSN 0014-2956.s 3971 - 3980.

  • Øynebråten, Inger; Hansen, Berit; Smedsrød, Bård; Uhlin-Hansen, Lars. Serglycin secreted by leukocytes is efficiently eliminated from the circulation by sinusoidal scavenger endothelial cells in the liver. Journal of Leukocyte Biology 2000; Volum 67. ISSN 0741-5400.s 183 - 188.

  • Hansen, Berit; Øynebråten, Inger; Uhlin-Hansen, Lars; Smedsrød, Bård. Elimination of blood monocyte proteoglycan by receptor-mediated endocytosis in rat liver sinusoidal endothelial cells. 1997 ISBN 90-803856-1-1.s 373-374 - .

  • Steigen, Sonja Eriksson; Wirsing, Anna Maria; Hadler-Olsen, Elin Synnøve; Uhlin-Hansen, Lars; Seppola, Marit; Ervik, Ida Korsnes. Oral cancer and high endothelial venules (HEV). Foredrag for studenter og ansatte 2017-10-16 - 2017-10-16 2017.

  • Wirsing, Anna; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve. Prognostic relevance of tertiary lymphoid structures in oral squamous cell carcinoma. 23rd Biennial Congress of the European Association for Cancer Research 2014-07-05 - 2014-07-08 2014.

  • Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers. Gordon Research Conference on MMPs 2013-05-19 - 2013-05-24 2013.

  • Svineng, Gunbjørg; Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Jacobsen, Cristiane Cavalcanti; Berg, Eli; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal induced expression of uPAR. Matrix Metalloproteinases Crucial Components of Molecular Networks and Disease Pathways 2013-05-19 - 2013-05-24 2013.

  • Solli, Ann Iren; Fadnes, Bodil Irene; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve. Intracellular MMP-2 localization and activity. Gordon Research Conference on Matrix Metalloproteinases 2013-05-19 - 2013-05-24 2013.

  • Wirsing, Anna; Hadler-Olsen, Elin Synnøve; Rikardsen, Oddveig G; Uhlin-Hansen, Lars. Tertiary lymphoid organs in oral squamous cell carcinoma. 43rd Annual Meeting German Society for Immunology 2013-09-11 - 2013-09-14 2013.

  • Stray-Pedersen, Arne; Rogde, Sidsel; Ormstad, Kari; Vege, Åshild; Delavaris, Gerd Jorunn; Skjerven-Martinsen, Marianne; Uhlin-Hansen, Lars; Nordrum, Ivar Skjåk; Morild, Inge; Lycke-Ellingsen, Christian; Holck, Per; Mynarek, Georg; Bosse, Gerhard; Rognum, Torleiv Ole. Forensic medical examination after the July 22nd 2011 terror attack. 18th Nordic Conference on Forensic Medicine 2012-06-13 - 2012-06-16 2012.

  • Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Tissue localization of intracellular gelatinolytic activity. The FEBS Journal 2012; Volum 279. ISSN 1742-464X.s 566 - 566.

  • Dupuy, Berit Myhre; Perchla, Dorota; Markussen, Gunnar; Rognum, Torleiv Ole; Uhlin-Hansen, Lars; Nordrum, Ivar Skjåk; Morild, Inge; Stenersen, Marguerethe. DNA-analysis for DVI or other identification purposes. Evaluation of the COPAN 4N6FLOQSwabs™ for collection of blood or tissue samples from deceased individuals. ISHI 23 International Symposium on Human Identification 2012-10-15 - 2012-12-18 2012.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Wetting, Hilde Ljones; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front. FEBS Advanced Lecture Course 2011matrix Pathobiology, Signalling and Molecular Targets 2011-09-02 - 2011-09-07 2011.

  • Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, O; Steigen, sonja eriksson; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2010; Volum 118 (3). ISSN 0903-4641.s 245 - 245.

  • Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-hansen, lars. Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front. European Journal of Cancer 2010. ISSN 0959-8049.s doi: 10.1111/j.1600-0463.2009.02578.x.

  • Malla, Nabin; Berg, Eli; Uhlin-hansen, lars; Winberg, Jan-Olof. Binding of promatrix metalloproteinase-9/ chondroitin sulphate proteoglycan complex to ECM. The XX FECTS Meeting 2006-07-01 - 2006-07-05 2006.

  • Berg, Eli; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The interaction between proMMP-9 and a proteoglycan core protein causes an intramolecular autoactivation in the presence of calcium. NBS kontaktmøte 2005-01-13 - 2005.

  • Berg, Eli; Malla, Nabin; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The matrix metalloproteinase-9 / chondroitin sulphate proteoglycan complex is produced from cells stimulated with the phorbolester PMA. NBS kontaktmøte 2005-01-13 - 2005-01-16 2005.

  • Berg, Eli; Malla, Nabin; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The matrix metalloproteinase-9 / chondroitin sulphate proteoglycan complex is produced from cells stimulated with the phorbolester PMA. The XIXth FECTS Meeting 2004-07-09 - 2004-07-13 2004.

  • Pejler, G; Henningsson, F; Winberg, Jan-Olof; Vuong, TT; Uhlin-Hansen, Lars; Kimata, K; Kolset, S O. Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans. Experimental Biology 2003 Meeting 2003-04-11 - 2003-04-15 2003.

  • Medlem i forskergruppe