Børre-Robertsen

Flag icon Flag icon

Robertsen, Børre

Professor Immunologi og sykdom hos fisk
Norges fiskerihøgskole

Stillingsbeskrivelse:
  • Forsker på immunologi og sykdommer hos laks og torsk.
  • Underviser på Bio-2604 Fiskesykdommer.



Forskningsinteresser

Virussykdommer forårsaker de største tapene i lakseoppdrett og er en kontinuerlig trussel mot næringen. Vi arbeider med laksens immunmekanismer mot infeksiøs lakseanemi-virus (ILAV), infeksiøs pankreas nekrosevirus (IPNV) og pankreas disease virus (SAV). Virus vil hele tiden forandre seg og tilpasse seg laks som vertsorganisme. Utfordringen er å sikre at laksens naturlige immunforsvar fungerer optimalt til å takle alle virusinfeksjonene den blir utsatt for, samt å lage mer effektive vaksiner mot virus. Min gruppe forsker på begge deler. Hovedinteressen er interferon-systemet som er den viktigste mekanismen i førstelinjeforsvaret mot virus og som også spiller en viktig rolle i den adaptive immuniteten som stimuleres ved vaksinering.

Normalt er både fisk og pattedyr ganske motstandsdyktige mot virus-infeksjoner på grunn av antivirus-aktiviteten til interferon-systemet. Frontsoldatene i dette forsvaret er alarm-proteiner som kalles interferoner og som produsere når et virus infiserer en celle. Interferon (IFN) sirkulerer rundt i kroppen og stimulerer produksjon av antivirus-proteiner i kroppscellene. De antivirale proteinene hindrer viruset i å formere seg og infeksjonen stopper opp. Svekkelse av interferon-systemet gir økt mottakelighet for virus-infeksjoner. Min forskningsgruppe var i 2003 blant de første i verden til å klone IFN fra fisk da vi identifiserte 2 IFN-gener hos laks. Senere har vi vist at laksen har et interferon-system som er nesten like komplekst som det en finner hos mennesker. Våre arbeider viser at laks har 3 hovedtyper av interferoner (IFNa, IFNb og IFNc) som kodes av mer enn 14 gener. Vi har laget såkalte rekombinante lakseinterferoner i bakterier og pattedyrceller og vist at de har kraftig hemmende effekt mot IPN- og PD-virus, men ikke mot ILA-virus. Vi arbeider videre med følgende temaer:

1) Hvordan bruke interferonsystemet til å forsterke effekten av laksevirus-vaksiner?

2) Hvordan hemmer virus syntese av interferon hos laks?

3) Hvordan unngår ILA-virus å bli hemmet av interferon?

4) Genetiske og funksjonelle studier av interferon-reseptorer.

5) ILA-virus vaksiner.

Arbeider i CRIStin


  • Robertsen, Børre; Greiner-Tollersrud, Linn; Jørgensen, Lars Gaute. Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Developmental and Comparative Immunology 2019; Volum 90. ISSN 0145-305X.s 80 - 89.s doi: 10.1016/j.dci.2018.09.004.

  • Robertsen, Børre. The role of type I interferons in innate and adaptive immunity against viruses in Atlantic salmon. Developmental and Comparative Immunology 2018; Volum 80. ISSN 0145-305X.s 41 - 52.s doi: 10.1016/j.dci.2017.02.005.

  • Sobhkhez, Mehrdad; Krasnov, Aleksei; Robertsen, Børre. Transcriptome analyses of Atlantic salmon muscle genes induced by a DNA vaccine against salmonid alphavirus, the causative agent of salmon pancreas disease (PD). PLoS ONE 2018; Volum 13:e0204924 (10). ISSN 1932-6203.s 1 - 16.s doi: 10.1371/journal.pone.0204924.

  • Chang, Chia Jung; Gu, Jinni; Robertsen, Børre. Protective effect and antibody response of DNA vaccine against salmonid alphavirus 3 (SAV3) in Atlantic salmon. Journal of Fish Diseases 2017; Volum 40 (12). ISSN 0140-7775.s 1775 - 1781.s doi: 10.1111/jfd.12644.

  • Sobhkhez, Mehrdad; Krasnov, Aleksei; Chang, Chia Jung; Robertsen, Børre. Transcriptome analysis of plasmid-induced genes sheds light on the role of type I IFN as adjuvant in DNA vaccine against infectious salmon anemia virus. PLoS ONE 2017; Volum 12:e0188456 (11). ISSN 1932-6203.s 1 - 20.s doi: 10.1371/journal.pone.0188456.

  • Chang, Chia Jung; Jenssen, Iris; Robertsen, Børre. Protection of Atlantic salmon against salmonid alphavirus infection by type I interferons IFNa, IFNb and IFNc. Fish and Shellfish Immunology 2016; Volum 57. ISSN 1050-4648.s 35 - 40.s doi: 10.1016/j.fsi.2016.08.020.

  • Li, Chun; Greiner-Tollersrud, Linn; Robertsen, Børre. Infectious salmon anemia virus segment 7 ORF1 and segment 8 ORF2 proteins inhibit IRF mediated activation of the Atlantic salmon IFNa1 promoter. Fish and Shellfish Immunology 2016; Volum 52. ISSN 1050-4648.s 258 - 262.s doi: 10.1016/j.fsi.2016.03.038.

  • Bakkemo, Kathrine Ryvold; Mikkelsen, Helene; Johansen, Audny; Robertsen, Børre; Seppola, Marit. Francisella noatunensis subsp. noatunensis invades, survives and replicates in Atlantic cod cells. Diseases of Aquatic Organisms 2016; Volum 121 (2). ISSN 0177-5103.s 149 - 159.s doi: 10.3354/dao03043.

  • Robertsen, Børre; Chang, Chia Jung; Bratland, Lisa Charlotte. IFN-adjuvanted DNA vaccine against infectious salmon anemia virus: Antibody kinetics and longevity of IFN expression. Fish and Shellfish Immunology 2016; Volum 54. ISSN 1050-4648.s 328 - 332.s doi: 10.1016/j.fsi.2016.04.027.

  • Lauksund, Reidunn Silje; Greiner-Tollersrud, Linn; Chang, Chia Jung; Robertsen, Børre. Infectious pancreatic necrosis virus proteins VP2, VP3, VP4 and VP5 antagonize IFNa1 promoter activation while VP1 induces IFNa1. Virus Research 2015; Volum 196. ISSN 0168-1702.s 113 - 121.s doi: 10.1016/j.virusres.2014.11.018.

  • Chang, Chia Jung; Sun, Baojian; Robertsen, Børre. Adjuvant activity of fish type I interferon shown in a virus DNA vaccination model. Vaccine 2015; Volum 33 (21). ISSN 0264-410X.s 2442 - 2448.s doi: 10.1016/j.vaccine.2015.03.093.

  • Furnes, Clemens; Kileng, Øyvind; Jensen, Ingvill; Karki, Pralav; Eichacker, Lutz; Robertsen, Børre. Isolation and characterisation of two cDNAs encoding transglutaminase from Atlantic cod (Gadus morhua). Fish and Shellfish Immunology 2014; Volum 36 (1). ISSN 1050-4648.s 276 - 283.s doi: 10.1016/j.fsi.2013.11.014.

  • Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B; Jørgensen, Jorunn B. Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts. FEBS Open Bio 2014; Volum 4. ISSN 2211-5463.s 858 - 871.s doi: 10.1016/j.fob.2014.09.007.

  • Sun, Baojian; Greiner-Tollersrud, Linn; Koop, Ben F; Robertsen, Børre. Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals. Developmental and Comparative Immunology 2014; Volum 47 (2). ISSN 0145-305X.s 275 - 286.s doi: 10.1016/j.dci.2014.08.007.

  • Chang, Chia Jung; Robertsen, Camilla; Sun, Baojian; Robertsen, Børre. Protection of Atlantic salmon against virus infection by intramuscular injection of IFNc expression plasmid. Vaccine 2014; Volum 32 (36). ISSN 0264-410X.s 4695 - 4702.s doi: 10.1016/j.vaccine.2014.05.059.

  • Svingerud, Tina; Holand, Jenni; Robertsen, Børre. Infectious salmon anemia virus (ISAV) replication is transiently inhibited by Atlantic salmon type I interferon in cell culture. Virus Research 2013; Volum 177 (2). ISSN 0168-1702.s 163 - 170.s doi: 10.1016/j.virusres.2013.08.004.

  • Markussen, Turhan; Dahle, Maria Krudtaa; Tengs, Torstein; Løvoll, Marie Therese; Finstad, Øystein Wessel; Wiik-Nielsen, Christer R.; Grove, Søren; Lauksund, Reidunn Silje; Robertsen, Børre; Rimstad, Espen. Sequence Analysis of the Genome of Piscine Orthoreovirus (PRV) Associated with Heart and Skeletal Muscle Inflammation (HSMI) in Atlantic Salmon (Salmo salar). PLoS ONE 2013; Volum 8 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0070075.

  • Svingerud, Tina; Solstad, Terese; Sun, Baojian; Nyrud, May Liss Julianne; Greiner-Tollersrud, Linn; Kileng, Øyvind; Robertsen, Børre. Atlantic salmon type I IFN subtypes show differences in antiviral activity and cell dependent expression - evidence for high IFNb/IFNc-producing cells in fish lymphoid tissues. Journal of Immunology 2012; Volum 189 (12). ISSN 0022-1767.s 5912 - 5923.s doi: 10.4049/jimmunol.1201188.

  • Robertsen, Børre. Can we get the upper hand on viral diseases in aquaculture of Atlantic salmon?. Aquaculture Research 2011; Volum 42 (S1). ISSN 1355-557X.s 125 - 131.s doi: 10.1111/j.1365-2109.2010.02671.x.

  • Sun, Baojian; SkjÆveland, ingrid; Svingerud, Tina; Zou, Jun; Jørgensen, Jorunn B; Robertsen, Børre. Antiviral Activity of Salmonid Gamma Interferon against Infectious Pancreatic Necrosis Virus and Salmonid Alphavirus and Its Dependency on Type I Interferon. Journal of Virology 2011; Volum 85 (17). ISSN 0022-538X.s 9188 - 9198.s doi: 10.1128/JVI.00319-11.

  • Furnes, Clemens; Robertsen, Børre. Molecular cloning and characterization of bloodthirsty from Atlantic cod (Gadus morhua). Fish and Shellfish Immunology 2010; Volum 29 (6). ISSN 1050-4648.s 903 - 909.s doi: 10.1016/j.fsi.2010.07.019.

  • Bergan, Veronica; Kileng, Øyvind; Sun, Baojian; Robertsen, Børre. Regulation and function of interferon regulatory factors of Atlantic salmon. Molecular Immunology 2010; Volum 47. ISSN 0161-5890.s 2005 - 2014.

  • Kileng, Øyvind; Bergan, Veronica; Workenhe, Samuel Tekeste; Robertsen, Børre. Structural and functional studies of an IRF-7-like gene from Atlantic salmon. Developmental and Comparative Immunology 2009; Volum 33 (1). ISSN 0145-305X.s 18 - 27.s doi: 10.1016/j.dci.2008.07.020.

  • Sun, Baojian; Robertsen, Børre; Wang, ZQ; Bin, L. Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties. Developmental and Comparative Immunology 2009; Volum 33 (4). ISSN 0145-305X.s 547 - 558.s doi: 10.1016/j.dci.2008.10.001.

  • Furnes, Clemens; Seppola, M; Robertsen, Børre. Molecular characterisation and expression analysis of interferon gamma in Atlantic cod (Gadus morhua). Fish and Shellfish Immunology 2009; Volum 26 (2). ISSN 1050-4648.s 285 - 292.s doi: 10.1016/j.fsi.2008.12.002.

  • Berg, Kristel; Svingerud, Tina; Sun, Baojian; Robertsen, Børre. An antiserum against Atlantic salmon IFNa1 detects IFN and neutralizes antiviral activity produced by poly I:C stimulated cells. Developmental and Comparative Immunology 2009; Volum 33 (4). ISSN 0145-305X.s 638 - 645.s doi: 10.1016/j.dci.2008.11.005.

  • Skjesol, Astrid; Aamo, Toril; Hegseth, Marit Nøst; Robertsen, Børre; Jørgensen, Jorunn B. The interplay between infectious pancreatic necrosis virus (IPNV) and the IFN system: IFN signaling is inhibited by IPNV infection. Virus Research 2009; Volum 143 (1). ISSN 0168-1702.s 53 - 60.s doi: 10.1016/j.virusres.2009.03.004.

  • Furnes, Clemens; Kileng, Øyvind; Rinaldo, Christine Hanssen; Seppola, Marit; Jensen, Ingvill; Robertsen, Børre. Atlantic cod (Gadus morhua L.) possesses three homologues of ISG15 with different expression kinetics and conjugation properties. Developmental and Comparative Immunology 2009; Volum 33 (12). ISSN 0145-305X.s 1239 - 1246.s doi: 10.1016/j.dci.2009.07.005.

  • Lauksund, Reidunn Silje; Svingerud, Tina; Bergan, Veronica; Robertsen, Børre. Atlantic salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappa B and localizes to mitochondria. Developmental and Comparative Immunology 2009; Volum 33 (11). ISSN 0145-305X.s 1196 - 1204.s doi: 10.1016/j.dci.2009.06.012.

  • Garcia Rosado, Esther; Markussen, Turhan; Kileng, Øyvind; Bækkevold, Espen S; Robertsen, Børre; Mjaaland, Siri; Rimstad, Espen. Molecular and functional characterization of two infectious salmon anaemia virus (ISAV) proteins with type I interferon antagonizing activity. Virus Research 2008; Volum 133. ISSN 0168-1702.s 228 - 238.

  • Robertsen, Børre. Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination. Fish and Shellfish Immunology 2008; Volum 25 (4). ISSN 1050-4648.s 251 - 357.

  • Seppola, Marit; Larsen, Atle Noralf; Steiro, Kari; Robertsen, Børre; Jensen, Ingvill. Characterisation and expression analysis of the interleukin genes, IL-1 beta, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.). Molecular Immunology 2008; Volum 45. ISSN 0161-5890.s 887 - 897.s doi: 10.1016/j.molimm.2007.08.003.

  • Bergan, Veronica; Jagus, Rosemary; Lauksund, Silje; Kileng, Øyvind; Robertsen, Børre. The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinase R. The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 184 - 197.s doi: 10.1111/j.1742-4658.2007.06188.x.

  • Kileng, Øyvind; Albuquerque, artur; Robertsen, Børre. Induction of interferon system genes in Atlantic salmon by the imidazoquinoline S-27609, a ligand for toll-like receptor 7. Fish and Shellfish Immunology 2008; Volum 24. ISSN 1050-4648.s 514 - 522.s doi: 10.1016/j.fsi.2007.10.005.

  • Garcia-Rosado, E; Markussen, T; Kileng, Øyvind; Baekkevold, ES; Robertsen, Børre; Mjaaland, Siri; Rimstad, E. Molecular and functional characterization of two infectious salmon anaemia virus (ISAV) proteins with type I interferon antagonizing activity. Virus Research 2008; Volum 133. ISSN 0168-1702.s 228 - 238.s doi: 10.1016/j.virusres.2008.01.008.

  • Røkenes, Torunn Pedersen; Larsen, Rannveig; Robertsen, Børre. Atlantic salmon ISG15: Expression and conjugation to cellular proteins in response to interferon, double-stranded RNA and virus infections. Molecular Immunology 2007; Volum 44. ISSN 0161-5890.s 950 - 959.

  • Seppola, Marit; Stenvik, Jørgen; Steiro, Kari; Solstad, Therese; Robertsen, Børre; Jensen, Ingvill. Sequence and expression analysis of an interferon stimulated gene (ISG15) from Atlantic cod (Gadus morhua L.). Developmental and Comparative Immunology 2007; Volum 31 (2). ISSN 0145-305X.s 156 - 171.

  • Kileng, Øyvind; Brundtland, Marthe Iren; Robertsen, Børre. Infectious salmon anemia virus is a powerful inducer of key genes of the type I interferon system of Atlantic salmon, but is not inhibited by interferon. Fish and Shellfish Immunology 2007; Volum 23. ISSN 1050-4648.s 378 - 389.s doi: 10.1016/j.fsi.2006.11.011.

  • Seppola, Marit; Robertsen, Børre; Jensen, Ingvill. The gene structure and expression of the non-specific cytotoxic cell receptor protein (NCCRP-1) in Atlantic cod (Gadus morhua L.). Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology 2007; Volum 147 (2). ISSN 1096-4959.s 199 - 208.s doi: 10.1016/j.cbpb.2007.01.023.

  • Jørgensen, Jorunn B; Johansen, Audny; Hegseth, Marit Nøst; Zou, Jun; Robertsen, Børre; Collet, Bertrand; Secombes, Christopher J. A recombinant CHSE-214 cell line expressing an Mx1 promoter-reporter system responds to both interferon type I and type II from salmonids ans represents a versatile tool to study the IFN-system in teleost fish. Fish and Shellfish Immunology 2007; Volum 23. ISSN 1050-4648.s 1294 - 1303.s doi: 10.1016/j.fsi.2007.07.008.

  • Robertsen, Børre. The interferon system of teleost fish. Fish and Shellfish Immunology 2006; Volum 20 (2). ISSN 1050-4648.s 172 - 191.

  • Bergan, Veronica; Steinsvik, Silje; Xu, Hao; Kileng, Øyvind; Robertsen, Børre. Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions. The FEBS Journal 2006; Volum 273 (17). ISSN 1742-464X.s 3893 - 3906.

  • Robertsen, Børre; Zou, Jun; Secombes, Chris; Leong, Jo-Ann. Molecular and expression analysis of an interferon-gamma-inducible guanylate binding protein from rainbow trout (Oncorhynchus mykiss). Developmental and Comparative Immunology 2006; Volum 30 (11). ISSN 0145-305X.s 1023 - 1033.

  • Larsen, Rannveig; Røkenes, Torunn Pedersen; Robertsen, Børre. Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein. Journal of Virology 2004; Volum 78 (15). ISSN 0022-538X.s 7938 - 7944.

  • Bergan, Veronica; Robertsen, Børre. Characterization of Atlantic halibut (Hippoglossus hippoglossus) Mx protein expression. Developmental and Comparative Immunology 2004; Volum 28. ISSN 0145-305X.s 1037 - 1047.

  • Robertsen, Børre; Bergan, veronica; Røkenes, Torunn; Larsen, rannveig; Albuquerque, artur. Atlantic salmon interferon genes: cloning, sequence analysis, expression, and biological activity. Journal of Interferon and Cytokine Research 2003; Volum 23. ISSN 1079-9907.s 601 - 612.

  • Jensen, Ingvill; Albuquerque, Artur; Sommer, Ann-Inger; Robertsen, Børre. Effect of poly I:C on the expression of Mx proteins and resistance against infection by infectious salmon anaemia virus in Atlantic salmon. Fish and Shellfish Immunology 2002; Volum 13. ISSN 1050-4648.s 311 - 326.s doi: 10.1006/fsim.2001.0406.

  • Bergan, veronica; Robertsen, Børre. Cloning of an Mx cDNA from Atlantic halibut (Hippoglossus hippoglossus) and charaterization of Mx mRNA expression in response to double-stranded RNA or infectious pancreatic necrosis virus. (data) Journal of Interferon and Cytokine Research 2000; Volum 20. ISSN 1079-9907.s 701 - 710.

  • Nygaard, Randi; Husgard, Susanna; Sommer, Ann Inger; Leong, Jo-Ann; Robertsen, Børre. Induction of Mx protein by interferon and double-stranded RNA in salmonid cells. Fish and Shellfish Immunology 2000; Volum 10 (5). ISSN 1050-4648.s 435 - 450.s doi: 10.1006/fsim.1999.0249.

  • Robertsen, Børre; Sobhkhez, Mehrdad; Krasnov, Aleksei. Transkriptom-analyser bidrar til å forklare beskyttende effekt av DNA-vaksiner mot ILA og PD. Havbruk 2018 2018-04-18 - 2018-04-20 2018.

  • Robertsen, Børre; Jørgensen, Lars Gaute. Effekt av interferon, poly I:C og virussmitte på induksjon av nyoppdagede Mx-gener hos atlantisk laks (Salmo salar L.). 2017.

  • Chang, Chia Jung; Gu, Jinni; Robertsen, Børre. DNA-vaksinering mot SAV3 gir bedre beskyttelse mot infeksjon og høyere antistoffrespons mot viruset enn vaksinering med Norvax Compact P. Frisk Fisk konferansen 2017 2017-02-01 - 2017-02-02 2017.

  • Ryvold Bakkemo, Kathrine; Robertsen, Børre. Francisella noatunensis ssp. noatunensis in Atlantic cod - intracellular localization, innate immune responses and antibacterial proteins. 2016.

  • Chang, Chia Jung; Robertsen, Børre. Atlantic salmon type I interferons: Protection against virus infection in vivo and function as adjuvants in a virus DNA vaccine. 2016.

  • Jenssen, Iris; Robertsen, Børre. Effekt av interferon-plasmider på ekspresjon av antiviralt Mx-protein i pankreas og beskyttelse mot SAV3-infeksjon hos atlantisk laks (Salmo salar L.).. 2015.

  • Bratland, Lisa Charlotte; Robertsen, Børre. Interferon som adjuvant i DNA-vaksine mot ILA-virus hos atlantisk laks (Salmo salar L.). 2015.

  • Chang, Chia Jung; Sun, Baojian; Robertsen, Børre. Type I interferons show strong adjuvant activity in DNA vaccination of Atlantic salmon against infectious salmon anemia virus.. 17th International Conference on Diseases of Fish and Shellfish 2015-09-07 - 2015-09-11 2015.

  • Chang, Chia Jung; Sun, Baojian; Robertsen, Børre. Type I interferon as adjuvant in fish DNA vaccination.. 13th International Congress in Developmental and Comparative Immunology 2015-06-28 - 2015-07-03 2015.

  • Robertsen, Børre; Chang, Chia Jung; Sun, Baojian. Interferon gir sterk økning i beskyttende effekt av DNA-vaksine mot ILA-virus. FRISK FISK-konferansen 2015-03-03 - 2015-03-04 2015.

  • Sun, Baojian; Greiner-Tollersrud, Linn; Koop, Ben F.; Robertsen, Børre. Identification of type I IFN receptors in Atlantic salmon. Norwegian Biochemical Society Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Chang, Chia Jung; Robertsen, Camilla; Sun, Baojian; Robertsen, Børre. Intramuskulær injeksjon av interferon-plasmid beskytter laks mot virus-infeksjon, nytt virkemiddel mot virussykdommer?. Programkonferansen HAVBRUK 2014 2014-03-31 - 2014-04-02 2014.

  • Lauksund, Reidunn Silje; Robertsen, Børre. Induction of Atlantic salmon type I interferon and antagonism by infectious pancreatic necrosis virus. 2014.

  • Robertsen, Børre. Interferon a, b, c og d har ulike funksjoner i medfødt immunitet mot virus hos laks. FRISK FISK 2013-02-05 - 2013-02-06 2013.

  • Robertsen, Camilla; Robertsen, Børre. Induksjon av antivirale gener hos atlantisk laks (Salmo salar L.) ved intramuskulær injeksjon av ekspresjonsplasmid for interferon c (IFNc). 2013.

  • Svingerud, T; Solstad, T; Sun, B; Nyrud, MLJ; Kileng, O; Greiner-Tollersrud, L; Robertsen, Børre. Distinct roles of interferon A, B, C and D in antiviral immunity of Atlantic salmon revealed by differences in antiviral activity and cell dependent expression. Fish and Shellfish Immunology 2013; Volum 34 (6). ISSN 1050-4648.s 1678 - 1679.

  • Sun, Baojian; Koop, B.; Robertsen, Børre. Atlantic salmon interferon receptors: Gene clusters and expression. Fish and Shellfish Immunology 2013; Volum 34 (6). ISSN 1050-4648.s 1740 - 1740.

  • Svingerud, Tina; Robertsen, Børre. Atlantic salmon type I interferons – Induction and antiviral activity. 2013.

  • Chang, Chia Jung; Robertsen, Camilla; Sun, Baojian; Robertsen, Børre. Protection of Atlantic salmon against infectious salmon anemia virus (ISAV) infection by intramuscular injection (i.m.) of IFNc expression plasmid. the 16th EAFP International conference on diseases of fish and shellfish 2013-09-02 - 2013-09-06 2013.

  • Johnsen, Jahn Petter; Toften, Hilde; Hoel, Alf H.; Robertsen, Børre. Hva må til for å sikre verdiskapning og bærekraftig vekst i havbruksnæringa i Troms?. Samrådsmøte havbruksstrategi form Troms 2013-03-14 - 2013-03-14 2013.

  • Holand, Jenni; Robertsen, Børre. Antiviral effekt av type I interferon hos atlantisk laks (Salmo salar L.) mot infeksiøs lakseanemi virus. 2012.

  • Sun, Baojian; Lauksund, Reidunn Silje; Chi, Heng; Li, Chun; Robertsen, Børre. Salmon Eris, an endoplasmatic reticulum IFN stimulator, activates antiviral signaling. 15th EAFP International conference on diseases of fish and shellfish 2011-09-12 - 2011-09-16 2011.

  • Lauksund, Reidunn Silje; Skjesol, Astrid; Jørgensen, Jorunn B; Robertsen, Børre. Identification of IPNV proteins that antagonize interferon synthesis. 15th EAFP International conference on diseases of fish and shellfish 2011-09-12 - 2011-09-16 2011.

  • Svingerud, Tina; Holand, Jenni; Mjaaland, Siri; Robertsen, Børre. Antiviral effekt av interferoner mot infeksiøs lakseanemivirus (ILAV). Frisk Fisk konferansen 2011 2011-01-19 - 2011-01-20 2011.

  • Robertsen, Børre; Sun, Baojian. Funksjonelle studier av interferon gamma (IFNg) fra laks. Programkonferansen Havbruk 2010 2010-04-19 - 2010-04-21 2010.

  • Sun, Baojian; SkjÆveland, ingrid; Svingerud, Tina; Zou, Jun; Jørgensen, Jorunn B; Robertsen, Børre. Antiviral activity of salmonid interferon gamma against infectious pancreatic necrosis virus (IPNV) is partially dependent on interferon a1 induction. First EOFFI (European Organisation of Fish Immunology) Symposium 2010-05-23 - 2010-05-27 2010.

  • Skjesol, Astrid; Hansen, Tom Egil; Aamo, Toril; Nøst Hegseth, Marit; Robertsen, Børre; Jørgensen, Jorunn B. The interplay between infectious pancreatic necrosis virus (IPNV) and the IFN system: IFN signaling is inhibited by IPNV infection. 11th congress of the International Society of Developmental and Comparative Immunology (ISDCI) 2009-06-28 - 2009-07-04 2009.

  • Bergan, Veronica; Kileng, Øyvind; Sun, Baojian; Robertsen, Børre. Atlantic salmon interferon regulatory factors. ISDCI conference 2009-06-28 - 2009-07-04 2009.

  • Svingerud, Tina; Lauksund, Silje; Bergan, Veronica; Robertsen, Børre. Identification and functional studies of an interferon promoter stimulating protein (IPS-1) from Atlantic salmon. ISDCI Congress 2009-06-28 - 2009-07-04 2009.

  • Robertsen, Børre. Can we get the upper hand on virus diseases in aquatic organisms?. Scottish Aquaculture: A sustainable future 2009-04-21 - 2009-04-22 2009.

  • Robertsen, Børre. Genomic and functional studies of the Atlantic salmon interferon multigene family. 11th International Congress International Society of Developmental and Comparative immunology 2009-06-28 - 2009-07-04 2009.

  • Robertsen, Børre. Atlantisk laks har 12 interferon-gener som uttrykker 3 ulike IFN-typer. Frisk Fisk 2009 2009-01-20 - 2009-01-21 2009.

  • Bergan, Veronica; Sun, Baojian; Svingerud, Tina; Robertsen, Børre. The type I interferon system of Atlantic salmon. Cytokines 2008 2008-10-12 - 2008-10-16 2008.

  • Kileng, Øyvind; Robertsen, Børre. Effect of viral mimics and ISA virus infection on expression of key genes of the Atlantic salmon interferon system. 2008.

  • Seppola, Marit Kristine; Robertsen, Børre. Genes involved in the innate immunity of Atlantic cod. 2008.

  • Bergan, veronica; Jagus, Rosemary; Steinsvik, Reidunn silje; Kileng, Øyvind; Robertsen, Børre. Atlantic salmon possesses two interferon inducible eIF2alpha kinases; PKR and PKZ. 7th INTERNATIONAL SYMPOSIUM ON FISH IMMUNOLOGY 2007-06-18 - 2007-06-22 2007.

  • Granfors, Johan; Robertsen, Børre. Studies of the salmonid alphavirus isolate NVI SAV 030605 in vitro. 2007.

  • Bergan, veronica; Steinsvik, Reidunn silje; Helland, Kirsti; Robertsen, Børre. Hvordan virus "skrur på" interferon-produksjonen hos laks. Frisk Fisk 2007 2007-01-23 - 2007-01-26 2007.

  • Robertsen, Børre. Effekt av interferonsystemet hos laks på ILA-virus og IPN-virus. Frisk Fisk-konferansen 2007 2007-01-23 - 2007-01-25 2007.

  • Robertsen, Børre. Interferon system genes of salmonids and their expression in response to virus infection, immunomodulators and vaccination. 7th Nordic Symposium on Fish Immunology 2007-06-19 - 2007.

  • Lauksund, Reidunn Silje; Robertsen, Børre. AsMAVS - et nøkkelprotein i signalveien for interferonsyntese hos laks. Frisk Fisk 2007 2007-01-23 - 2007-01-25 2007.

  • Kileng, Øyvind; Granfors, Johan; Robertsen, Børre. Interactions between a Norwegian salmonid alphavirus and the interferon system of Atlantic salmon. EUROPEAN ASSOCIATION OF FISH PATHOLOGISTS (EAFP) annual meeting 2007-09-16 - 2007-09-20 2007.

  • Bergan, veronica; Jagus, Rosemary; Steinsvik, Reidunn silje; Robertsen, Børre. The Atlantic salmon z-DNA binding protein kinase phosphorylates eIF2alpha and constitutes a unique orthologue to the mammalian dsRNA activated protein kinase R. 10th international ISDCI conference 2006 2006-07-01 - 2006-07-06 2006.

  • Jensen, Marthe Iren; Robertsen, Børre. Interaksjon mellom infeksiøs lakseanemivirus og interferonsystemet hos laks. 2006.

  • Helland, Kirsti; Robertsen, Børre. The effect of infectious pancreatic necrosis virus (IPNV) genes on induction of promoter region I of the Atlantic salmon IFNalfa1 promoter with poly I:C. 2006.

  • Markussen, Øystein; Robertsen, Børre. Interaksjoner mellom interferon-systemet hos atlantisk laks (Salmo salar) og infeksiøs pankreasnekrose-virus. 2006.

  • Workenhe, Samuel Tekeste; Robertsen, Børre. Expression of type I interferon system genes in Atlantic salmon: Antiviral Mx gene and the transcription factors IRF-7 and STAT-1. 2006.

  • Finstad, Solrun; Robertsen, Børre. Functional studies of the interferon induced protein ISG15 in Atlantic salmon comparing EGFP tagged AsISG15 with endogenous AsISG15. 2006.

  • Kileng, Øyvind; Brundtland, Marthe Iren; Robertsen, Børre. ILA-virus induserer nøkkel-gener i interferon-systemet hos Atlantisk laks, men blir ikke hemmet av interferon. Programkonferansen HAVBRUK 2006 2006-03-29 - 2006-03-31 2006.

  • Bergan, veronica; Steinsvik, Reidunn silje; Xu, Hao; Robertsen, Børre. Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions. 10th Congress of the International Society of Developmental and Comparative Immunology 2006-07-01 - 2006-07-06 2006.

  • Kileng, Øyvind; Jensen, Marthe Iren; Robertsen, Børre. ILA-virus induserer nøkkel-gener i interferon-systemet hos Atlantisk laks, men blir ikke hemmet av interferon. Programkonferansen HAVBRUK 2006 2006-03-29 - 2006-03-31 2006.

  • Bergan, veronica; Steinsvik, Silje; Xu, Hao; Kileng, Øyvind; Robertsen, bØrre. Promoter analysis of two Atlantic salmon type I interferon genes. 2005 Annual meeting of International Society for Interferon and Cytokine Research 2005-10-20 - 2005-10-24 2005.

  • Jensen, Marthe; Kileng, Øyvind; Robertsen, Børre. Interaction of the interferon system in Atlantic salmon and infectious salmon anemia virus. EAFP 12th International Conference 2005-09-11 - 2005-09-16 2005.

  • Seppola, Marit; Stenvik, jØrgen; Rinaldo, Christine; Robertsen, Børre; Jensen, Ingvild. Genomic organization and quantitative real time PCR expression of ISG15 in Atlantic cod (Gadus morhua). EAFP 12th International Conference 2005-09-11 - 2005-09-16 2005.

  • Kileng, Øyvind; Jensen, Marthe; Markussen, Øystein; Larsen, rannveig; Robertsen, Børre. The effect of IPNV and ISAV infections on the expression of interferon and interferon-induced proteins in Atlantic salmon. EAFP 12th International Conference 2005-09-11 - 2005-09-16 2005.

  • Mjaaland, Siri; Robertsen, Børre; Grimholt, Unni; Solem, Stein Tore; Jørgensen, Trond Ø.; Hordvik, Ivar; Press, Charles Mcl; Koppang, Erling O; Kirkeng Andersen, Elisabeth. Lakseinfluensa. 2005.

  • Mjaaland, Siri; Robertsen, Børre; Grimholt, Unni; Solem, Stein Tore; Jørgensen, Trond Ø.; Hordvik, Ivar; Press, Charles Mcl; Koppang, Erling O; Kirkeng Andersen, Elisabeth. Laksen er lik mennesket. 2005.

  • Mjaaland, Siri; Robertsen, Børre; Grimholt, Unni; Solem, Stein Tore; Jørgensen, Trond Ø.; Hordvik, Ivar; Press, Charles Mcl; Koppang, Erling O; Kirkeng Andersen, Elisabeth. Hva skjer når laksen får influensa?. 2005.

  • Larsen, rannveig; Robertsen, Børre. Type I interferon and two interferon induced proteins, Mx and ISG15, in Atlantic salmon. 2005.

  • Bergan, veronica; Robertsen, Børre. Atlantic halibut Mx genes and proteins, and Atlantic salmon interferon genes. Cloning, characterization and expression. 2004.

  • Publikasjoner utenfor Cristin

    Sun B, Skjaeveland I, Svingerud T, Zou J, Jørgensen J, Robertsen B (2011). Antiviral activity of salmonid interferon gamma against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type I interferon. J Virol 85 (17):9188-9198.

    Robertsen B. (2011). Can we get the upper hand on viral diseases in aquaculture of Atlantic salmon? Aquaculture Research 42: 125-131.

    Bergan V, Kileng Ø, Sun B and Robertsen B (2010). Regulation and function of interferon regulatory factors of Atlantic salmon. Mol Immunol 47:2005-2014.

    Lauksund S, Svingerud T, Bergan V, Robertsen B. (2009). Atlantic salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria. Dev Comp Immunol 33(11):1196-204.

    Berg K, Svingerud T, Sun B, Robertsen B. (2009). An antiserum against Atlantic salmon IFNa1 detects IFN and neutralizes antiviral activity produced by poly I:C stimulated cells. Dev Comp Immunol 33:638-45.

    Sun B, Robertsen B, Wang Z, Liu B. (2009). Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties. Dev Comp Immunol 33:547-58.

    Robertsen B. (2008). Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination. Fish Shellfish Immunol. 25(4):351-357.

    Kileng Ø, Brundtland MI, Robertsen B. (2007). Infectious salmon anemia virus is a powerful inducer of key genes of the type I interferon system of Atlantic salmon, but is not inhibited by interferon. Fish Shellfish Immunol. 23: 378-389.

    Røkenes T, Larsen R and Robertsen B (2007). Atlantic salmon ISG15: expression and conjugation to cellular proteins in response to interferon, double-stranded RNA and virus infections. Molecular Immunology 44: 950-959.

    Robertsen B. (2006). The interferon system of teleost fish. Fish Shellfish Immunol 20:172-191

    Bergan, V., Steinsvik, S., Xu, H., Kileng, Ø. and Robertsen, B. (2006). Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions. FEBS Journal 273: 3893-3906

    Larsen R, Røkenes T, and Robertsen B (2004). Inhibition of infectious pancreatic necrosis virus replication by the Atlantic salmon Mx1 protein. Journal of Virology 78: 7938-7944.

    Medlem i forskergruppe