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Leiros, Hanna-Kirsti Schrøder

Forsker, Strukturkjemi, Norstruct
Kjemi

Stillingsbeskrivelse:

Krystallisering av proteiner. Struktur bestemmelse og protein struktur analyse. Struktur ligand interaksjoner. Veiledning av studenter.

Veiledning av studenter.




Forskningsinteresser

Antibiotika resistens, β-laktamer, Metallo-β-lactamases, Serine-β-lactamases, protein ligand interaksjoner, fragment screening, Surface plasmon resonance (SPR), biofysikalsk karakterisering, Drug Design, protein krystallografi.

Jobber i gruppa strukturkjemi

Er gruppeleder i LacZymes.

Forskningsprosjekter

LacZymes, som fokuserer på metallo-b-laktamaser (MBL) og serine-b- laktamaser (SBL) som er involvert i antibiotika resistens. Se hjemmesiden til LacZymes

  • Combating Antibiotic Resistance - Development of Inhibitors against Antibiotic Resistance Enzymes
  • High Throughput Pipeline for Structure Based Drug Design, and Antibiotic Resistance Enzymes in particular
  • ZinChel: Combating antibiotic resistance-hit to lead development of a new metallo-β-lactamase inhibitor

Biografiske data

Utenlands opphold:

1994: 6 måneder i Groningen, Nederland.

1999: 6 måneder ved EMBL i Grenoble, Frankrike.

2003-2005: Post Doc. ved ESRF i Grenoble, Frankrike.

Andre publikasjoner

Her er et innslag på NRK fra programmet “Schrödingers katt”, 5.3.2015 som viser hva vi jobber med. Hovedpersonen er PhD student Bjarte Aarmo Lund. Innsalget heter: “Krystaller mot antibiotikaresistens”.

Forskerprofil i Cristin

Klikk her

Arbeider i CRIStin


  • Christopeit, Tony; Albert, Anastasia; Leiros, Hanna-Kirsti S.. Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1. Bioorganic & Medicinal Chemistry 2016; Volum 24 (13). ISSN 0968-0896.s 2947 - 2953.s doi: 10.1016/j.bmc.2016.04.064.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Investigating the role of residues W228 and Y233 in the structure and activity of the GIM-1 metallo-beta-lactamase.. Antimicrobial Agents and Chemotherapy 2016; Volum 60 (2). ISSN 0066-4804.s 990 - 1002.s doi: 10.1128/AAC.02017-15.

  • Christopeit, Tony; Leiros, Hanna-Kirsti S.. Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2. Bioorganic & Medicinal Chemistry Letters 2016; Volum 26 (8). ISSN 0960-894X.s 1973 - 1977.s doi: 10.1016/j.bmcl.2016.03.004.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Guttormsen, Yngve; Bayer, Annette; Leiros, Hanna-Kirsti S.. Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. Journal of Medicinal Chemistry 2016. ISSN 0022-2623.s doi: 10.1021/acs.jmedchem.6b00660.

  • De Santi, Concetta; Leiros, Hanna-Kirsti S.; Di Scala, Alessia; de Pascale, Donatella; Altermark, Bjørn; Willassen, Nils Peder. Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp.. Extremophiles 2016; Volum 20 (3). ISSN 1431-0651.s 323 - 336.s doi: doi: 10.1007/s00792-016-0824-z.

  • Lian, Kjersti; Leiros, Hanna-Kirsti S.; Moe, Elin. MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability. FEBS Open Bio 2015; Volum 5. ISSN 2211-5463.s 107 - 116.s doi: 10.1016/j.fob.2015.01.006.

  • Hansen, Hilde; Purohit, Amit Anand; Leiros, Hanna-Kirsti S.; Johansen, Jostein; Kellermann, Stefanie J.; Bjelland, Ane Mohn; Willassen, Nils Peder. The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida. BMC Microbiology 2015; Volum 15 (69). ISSN 1471-2180.s doi: 10.1186/s12866-015-0402-z.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Helland, Ronny; Leiros, Hanna-Kirsti S.. Discovery of Novel Inhibitor Scaffolds against the Metallo-beta-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening. Journal of Medicinal Chemistry 2015; Volum 58 (21). ISSN 0022-2623.s 8671 - 8682.s doi: 10.1021/acs.jmedchem.5b01289.

  • Aubi Catevilla, Oscar; Flydal, Marte Innselset; Zheng, Huaixin; Skjærven, Lars; Rekand, Illimar; Leiros, Hanna-Kirsti S.; Haug, Bengt Erik; Cianciotto, Nicholas P.; Martinez, Aurora; Underhaug, Jarl. Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila. Journal of Medicinal Chemistry 2015; Volum 58 (21). ISSN 0022-2623.s 8402 - 8412.s doi: 10.1021/acs.jmedchem.5b01589.

  • Leiros, Hanna-Kirsti S.; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan. Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases. The FEBS Journal 2015; Volum 282 (6). ISSN 1742-464X.s 1031 - 1042.s doi: 10.1111/febs.13200.

  • Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S.. Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (11). ISSN 0907-4449.s 3043 - 3056.s doi: 10.1107/S1399004714021099.

  • Assefa, Netsanet Gizaw; Niiranen, Laila; Johnson, Kenneth; Leiros, Hanna-Kirsti S.; Smalås, Arne O.; Willassen, Nils Peder; Moe, Elin. Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi). Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (8). ISSN 0907-4449.s 2093 - 2100.s doi: 10.1107/S1399004714011699.

  • Leiros, Hanna-Kirsti S.; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan. His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (8). ISSN 0066-4804.s 4826 - 4836.s doi: 10.1128/AAC.02735-13.

  • Sivertsen, Annfrid; Isaksson, Johan; Leiros, Hanna-Kirsti S.; Svenson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin. BMC Structural Biology 2014; Volum 14:4. ISSN 1472-6807.s doi: 10.1186/1472-6807-14-4.

  • Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Bjerga, Gro Elin Kjæreng. A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement. Microbial Cell Factories 2014; Volum 13:38. ISSN 1475-2859.s doi: 10.1186/1475-2859-13-38.

  • Fu, Juan; Leiros, Hanna-Kirsti S.; De pascale, Donatella; Johnson, Kenneth; Blencke, Hans-Matti; Landfald, Bjarne. Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library. Applied Microbiology and Biotechnology 2013; Volum 97. ISSN 0175-7598.s 3965 - 3978.s doi: 10.1007/s00253-012-4276-9.

  • Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora. Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila. FEBS Open Bio 2013; Volum 3. ISSN 2211-5463.s 370 - 378.s doi: 10.1016/j.fob.2013.08.006.

  • Borra, Naga Pardha Saradhi; Samuelsen, Ørjan; Spencer, James; Walsh, Timothy R.; Lorentzen, marit sjo; Leiros, Hanna-Kirsti S.. Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo-beta-Lactamases. Antimicrobial Agents and Chemotherapy 2013; Volum 57 (2). ISSN 0066-4804.s 848 - 854.s doi: 10.1128/AAC.02227-12.

  • Purohit, Amit Anand; Johansen, Jostein a; Hansen, Hilde; Leiros, Hanna-Kirsti S.; Kashulin, Alexander; Karlsen, Christian; Smalås, Arne O.; Haugen, Peik; Willassen, Nils Peder. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. Journal of Applied Microbiology 2013; Volum 115 (3). ISSN 1364-5072.s 835 - 847.s doi: 10.1111/jam.12264.

  • Leiros, Hanna-Kirsti S.; Borra, Naga Pardha Saradhi; Brandsdal, Bjørn Olav; Edvardsen, Kine Susann Waade; Spencer, James; Walsh, Timothy R.; Samuelsen, Ørjan. Crystal Structure of the Mobile Metallo-beta-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157. Antimicrobial Agents and Chemotherapy 2012; Volum 56 (8). ISSN 0066-4804.s 4341 - 4353.s doi: 10.1128/AAC.00448-12.

  • Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene. The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism. FEBS Open Bio 2012. ISSN 2211-5463.

  • Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.

  • Leiros, Hanna-Kirsti S.; Brandsdal, Bjørn Olav; McSweeney, Seán M.. Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans. Biochimica et Biophysica Acta - Proteins and Proteomics 2010; Volum 1804 (4). ISSN 1570-9639.s 967 - 976.s doi: 10.1016/j.bbapap.2010.01.010.

  • Pedersen, hege lynum; Ahmad, Rafi; Riise, EK; Leiros, Hanna-Kirsti S.; Hauglid, Stefan; Espelid, S; Brandsdal, Bjørn Olav; Leiros, Ingar; Willassen, Nils P; Haugen, Peik. Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida). Journal of Microbiology 2010; Volum 48 (2). ISSN 1225-8873.s 174 - 183.s doi: 10.1007/s12275-010-9199-5.

  • Niiranen, Laila Mirja; Altermark, Bjørn; Brandsdal, Bjørn Olav; Leiros, Hanna-Kirsti S.; Helland, Ronny; Smalås, Arne Oskar; Willassen, Nils Peder. Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae. The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 1593 - 1605.s doi: 10.1111/j.1742-4658.2008.06317.x.

  • Leiros, Hanna-Kirsti S.; Tedesco, Consiglia; McSweeney, Seán M.. High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2008; Volum 64. ISSN 1744-3091.s 442 - 447.s doi: 10.1107/S1744309108009901.

  • Riise, Ellen Kristin; Lorentzen, marit sjo; Helland, Ronny; Smalås, Arne Oskar; Leiros, Hanna-Kirsti S.; Willassen, Nils Peder. The first structure of a cold-active catalase from Vibrio salmonicida at 1.96 angstrom reveals structural aspects of cold adaptation. Acta Crystallographica Section D: Biological Crystallography 2007; Volum 63. ISSN 0907-4449.s 135 - 148.s doi: 10.1107/S0907444906043812.

  • Fedøy, Anita-Elin; Fedoy, AE; Yang, Nannan; Martinez, A; Leiros, Hanna-Kirsti S.; Steen, IH. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. Journal of Molecular Biology 2007; Volum 372. ISSN 0022-2836.s 130 - 149.s doi: 10.1016/j.jmb.2007.06.040.

  • Wang, Ellen; Koutsioulis, D.; Leiros, Hanna-Kirsti S.; Andersen, Ole Andreas; Bouriotis, V.; Hough, Edward; Heikinheimo, Pirkko a. Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5. Journal of Molecular Biology 2007; Volum 366. ISSN 0022-2836.s doi: 10.1016/j.jmb.2006.11.079.

  • Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry 2007; Volum 282. ISSN 0021-9258.s doi: 10.1074/jbc.M610174200.

  • Leiros, Hanna-Kirsti S.; McSweeney, Sean. The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 Å resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains. Journal of Structural Biology 2007; Volum 159. ISSN 1047-8477.s 92 - 102.

  • Leiros, Hanna-Kirsti S.; Timmins, J.; Ravelli, R.B.; McSweeney, Seán M.. Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?. Acta Crystallographica Section D: Biological Crystallography 2006; Volum 62. ISSN 0907-4449.s 125 - 132.

  • Weik, M.; Schreurs, A.M.; Leiros, Hanna-Kirsti S.; Zaccai, G.; Ravelli, R.B.; Gros, P.. Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies. Journal of Synchrotron Radiation 2005; Volum 12 (3). ISSN 0909-0495.s 310 - 317.

  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal structure of maltooligosyltrehalose trehalohydrolase from Deinococcus radiodurans in complex with disaccharides. Journal of Molecular Biology 2005; Volum 347 (5). ISSN 0022-2836.s 949 - 963.

  • Leiros, Hanna-Kirsti S.; Leiros, Hanna Kirsti Schrøder; Brandsdal, Bjørn Olav; Andersen, Ole Andreas; Os, vibeke; Leiros, Ingar; Leiros, Ingar; Helland, Ronny; Otlewski, J.; Otlewski, Jacek; Willassen, Nils Peder; Smalås, Arne Oskar. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Science 2004; Volum 13. ISSN 0961-8368.s 1056 - 1070.

  • Leiros, Hanna-Kirsti S.; Kozielski-Stuhrmann, S.; Kapp, U; Terradot, L; Leonard, G.A; McSweeney, Seán M.. Structural basis of 5-nitroimidazole antibiotic resistance: The crystal structure of NimA from Deinococcus radiodurans. Journal of Biological Chemistry 2004; Volum 279 (53). ISSN 0021-9258.s 55840 - 55849.

  • Ravelli, R.G.B.; Leiros, Hanna-Kirsti S.; Pan, B.; Caffrey, M.; McSweeney, Seán M.. Specific radiation damage can be used to solve macromolecular crystal structures. Structure 2003; Volum 11 (2). ISSN 0969-2126.s 217 - 214.

  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; McSweeney, Sean; Hough, Edward. The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation. Journal of Molecular Biology 2003; Volum 327 (3). ISSN 0022-2836.s 631 - 644.

  • Leiros, Hanna-Kirsti S.; McSweeney, Seán M.; Smalås, Arne Oskar. Atomic resolution structures of trypsin provide insight into structural radiation damage. Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57. ISSN 0907-4449.s 488 - 497.

  • Smalås, Arne Oskar; Leiros, Hanna-Kirsti S.; Os, V.; Willassen, Nils Peder. Cold adapted Enzymes. Biotechnology Annual Review 2000; Volum 6. ISSN 1387-2656.s 1 - 57.

  • Gorfe, A.A.; Brandsdal, Bjørn Olav; Leiros, Hanna-Kirsti S.; Helland, Ronny; Smalås, Arne Oskar. Electrostatics of mesophilic and psychrophilic trypsin isoenzymes: qualitative evaluation of electrostatic differences at the substrate binding site. Proteins: Structure, Function, and Genetics 2000; Volum 40. ISSN 0887-3585.s 207 - 217.

  • Leiros, Hanna-Kirsti S.; Willassen, Nils Peder; Smalås, Arne Oskar. Structural comparison of psychrophilic and mesophilic trypsins. Elucidating the molecular basis of cold-adaptation. European Journal of Biochemistry 1999; Volum 267. ISSN 0014-2956.s 1039 - 1049.

  • Leiros, Hanna-Kirsti S.; Willassen, Nils Peder; Smalås, Arne Oskar. Residue determinants and sequence analysis of cold-adapted trypsins. Extremophiles 1999; Volum 3. ISSN 1431-0651.s 205 - 219.

  • Ahkter, Sundus; Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Addressing Antibiotic Resistance: Fragment-Based Design of OXA-48 Inhibitors. 31. Organisk Kjemisk Vintermøte 2016-01-07 - 2016-01-10 2016.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Ahkter, Sundus; Guttormsen, Yngve; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-Guided Drug Design for the Antibiotic Resistance Enzyme OXA-48. ASM Microbe 2016 2016-06-16 - 2016-06-20 2016.

  • Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Lund, Bjarte Aarmo; Akhter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Isaksson, Johan; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 7th Annual BioStruct Conference 2016-08-25 - 2016-08-28 2016.

  • Nesheim, Birgit Berg; Carlsen, Trine Josefine Olsen; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.. Residue profiling of antibiotic resistant OXA-beta-lactamases through mutagenesis, enzyme kinetics and 3D structures. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Albert, Anastasia; Skagseth, Susann; Leiros, Hanna-Kirsti S.. Discovery of a Novel Covalent Inhibitor of the Metallo-beta-lactamase NDM-1. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The impact of residues 119 and 228 in the Tripoli metallo-beta-lactamase TMB-1 involved in resistance to beta-lactam antibiotics. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors.. Cambridge Healthtech Institute’s (CHI) Drug Discovery Chemistry conference. 2015-04-22 - 2015-04-23 2015.

  • Leiros, Hanna-Kirsti S.. Enzymatic characterization and structural insight into Metallo-beta-Lactamases (MBL) and Serine-beta-lactamases (SBL). Pre-Centre for Infection Prevention and Treatment (preCIPT) 2015-10-14 - 2015.

  • Christopeit, Tony; Lund, Bjarte Aarmo; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using Fragment Screening to Identify Novel Starting Points for Potent Carbapenemase Inhibitors. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) 2015-09-17 - 2015-09-21 2015.

  • Leiros, Hanna-Kirsti S.. Can We Overcome beat-Lactamase-mediated Antibiotic Resistance Through Inhibitor Screening?. Norwegian Biochemical Society Contact Meeting 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette; Rongved, Pål. Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria. Organisk Kjemisk Vintermøte 2015 2015-01-08 - 2015-01-11 2015.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Fragment-based screening for class D β-lactamase inhibitors. Combating antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Using fragment screening to identify novel starting points for potent inhibitors of metallo-beta-lactamase VIM-2. Fragments 2015: Fifth RSC-BMCS Fragment-based Drug Discovery meeting 2015-03-22 - 2015-03-22 2015.

  • Leiros, Hanna-Kirsti S.. Fighting Antibiotic Resistance Through Inhibitor Screening – Can Crystal Structures Help Out?. Norwegian Biochemical Society (NBS), avd Ås, Seminar serie 2015-06-23 - 2015-06-23 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Design of OXA-48 class D beta-lactamase inhibitors by fragment-based drug design. Annual BioStruct Conference, The National graduate school in structural biology 2015-08-27 - 2015-08-30 2015.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens. Hvorfor virker ikke antibiotikaet når vi er syke? Hva gjør en kjemiker med det?. Kjemikonferansen 2015 2015-01-22 - 2015-01-22 2015.

  • Lund, Bjarte Aarmo; Christopeit, Tony; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Combating antibiotic resistance: Fragment-based screening for class D β-lactamase inhibitors. BioStruct OpenDay 2015-03-20 - 2015-03-20 2015.

  • Leiros, Hanna-Kirsti S.. On the Road Searching for Inhibitors against beta-Lactamases Involved in Antibiotic Resistance. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Leiros, Hanna-Kirsti S.; Beck, Ellen-Marie. 100 år med krystallografi, 100 years with crystallography.. Utstilling i glassmonter, 3.4x1 meter, Poster og gjenstander 2014-11-07 - 2015-04-07 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. The 46th INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 2014-05-30 - 2014-06-08 2014.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Lund, Bjarte Aarmo; Bjerga, Gro Elin Kjæreng; Christopeit, Tony; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Structural view on antibiotic resistance. Fragment-based lead discovery for the inhibition of oxacillinases. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Christopeit, Tony; Carlsen, Trine Josefine Olsen; Skagseth, Susann; Lund, Bjarte Aarmo; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. Characterization of substrate and inhibitor binding to different beta-lactamases using Surface Plasmon Resonance based biosensors. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Lorentzen, marit sjo; Leiros, Ingar; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. Site-directed mutagenesis of metallo-beta-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa. NBS konferanse 2013-01-31 - 2013-02-03 2013.

  • Ove Alexander, Høgmoen Åstrand; Edvardsen, Kine Susann Waade; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette; Rongved, Pål. Metallo-β-lactamase inhibitors. 2013.

  • Leiros, Hanna-Kirsti S.. Metallo-beta-Lactamases Cause Clinical Problems due to Antibiotic Resistance. Can Crystal Structures Help Out?. Norsk Biokjemisk Selskap (NBS) 49th Contact Meeting 2013-01-31 - 2013-02-03 2013.

  • Fonseca, Davi de Miranda; Baar, Cecilie Christensen; Assefa, Netsanet Gizaw; Moe, Elin; Liabakk, Nina-Beate; Leiros, Hanna-Kirsti S.; Aas, Per Arne; Skorpen, Frank; Krokan, Hans Einar. Thermo-sensitive human UNG-mutants. XII Annual SBDR Program Project Workshop 2013-04-11 - 2013-04-13 2013.

  • Leiros, Hanna-Kirsti S.. Radiation damage. BioStruct- Synchrotron Data Collection, ESRF 2013-09-09 - 2013-09-13 2013.

  • Fedøy, Anita-Elin; Leiros, Hanna-Kirsti S.; Steen, Ida Helene; Birkeland, Nils-Kåre. Bacterial subfamiliy II isocitrate dehydrogenase: adaptations to low and high temperatures. Extremophiles 2012 2012-09-10 - 2012-09-13 2012.

  • Leiros, Hanna-Kirsti S.. Antibiotikaresistent - hva nå. Science - who cares? 2010-09-02 - 2010.

  • Leiros, Hanna-Kirsti S.. Antibiotika resistens: en utfordring både for forskere og kliniske behandlere. Populærvitenskaplige fordragsserie (fulltekst) 2010-12-03 - 2010.

  • Leiros, Hanna-Kirsti S.; Pey, Angel L.; Innselset, M; Moe, Elin; Leiros, Ingar; Steen, Ida Helene; Martinez, Aurora. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Norwegian Biochemical Society (NBS) contact meeting 2008 2008-01-17 - 2008-01-20 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-Kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila. The Norwegian Biochemical Society 44th Contact Meeting 2008-01-17 - 2008-01-20 2008.

  • Leiros, Hanna-Kirsti S.. A structural view on antibiotic resistance: DrNimA (DR0842) from Deinococcus radiodurans. Combating Antibiotic Resistance-Development of Inhibitors against Antibiotic Resistance Enzymes. 2008-08-13 - 2008-08-13 2008.

  • Fedøy, Anita-Elin; Yang, Nannan; Martinez, Aurora; Leiros, Hanna-kirsti S.; Steen, Ida Helene. A cold-active enzyme with an unusual high thermal stability: Isocitrate dehydrogenase from the psycrophilic bacterium Desulfotalea psycrophila. Extremophiles 2008 2008-09-07 - 2008-09-11 2008.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avoid it while collecting X-ray data and how to use it. 19th Nordic Structural Chemistry Meeting, NSM 19 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Radiation Damage and Dose-Rate effects on heavy atoms. Guest lecture at Department of Chemistry, University of Oslo, Norway. 2007-10-19 - 2007-10-19 2007.

  • Leiros, Hanna-Kirsti S.. Crystal Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H - reveals a monomeric cold active enzyme with local flexibility around the active site and high overall stability. 9th International Conference on Biology and Synchrotron Radiation 2007-08-12 - 2007-08-17 2007.

  • Leiros, Hanna-Kirsti S.. Radiation damage: How to avid it while colleting X-ray data and how to use it solving new protein structures. 19th Nordic Structural Chemistry Meeting 2007-01-08 - 2007-01-11 2007.

  • Leiros, Hanna-Kirsti S.. Phenylalanine hydroxylase from the cold adapted bacterium Colwellia psychrerythraea 34: - Biochemical and structural properties. NorStruct seminar at Sommarøy, Norway 2006-12-07 - 2006-12-08 2006.

  • Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Birkeland, Nils-Kåre; Steen, Ida Helene. Biochemical and structural basis of cold-adaptation in isocitrate dehydrogenase from Desulfotalea psychrophila. Extremophiles 2006 2006-09-17 - 2006-09-21 2006.

  • Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal Structure of Maltooligosyltrehalose Trehalohydrolase from D. radiodurans. ESRF Highlights 2005 2006.s 68 - 70.

  • Steen, Ida Helene; Fedøy, Anita-Elin; Yang, Nannan; Leiros, Hanna-Kirsti S.; Karlström, Mikael; Ladenstein, Rudolf; Birkeland, Nils-Kåre. Biochemical characterization and structure analysis of extremophilic isocitrate dehydrogenase. From functional genomics to natural products of marine microorganisms 2006-06-21 - 2006-06-24 2006.

  • Leiros, Hanna-Kirsti S.. Is the Deinococcus radiodurans protein DR2241 a chelatase? Inserting Fe or Co2+ into Hemes?. ESRF Macro Molecular science day, Col de Porte, Grenoble, France. 2005-06-14 - 2005-06-14 2005.

  • Leiros, Hanna-Kirsti schrøder; McSweeney, Seán M.. Radiation Damage and Dose-Rate effects on heavy atoms. Gjesteforelesning 2005-10-19 - 2005-10-19 2005.

  • Hall, David Richard; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Micossi, E.; Gordon, E.; Macedo, S.; Kapp, U.; Jamin, C.; Timmins, Joanna; Leonard, Gordon; McSweeney, Sean. Structural Genomics at the ESRF: Studying Deinococcus radiodurans. ESRF Highlights 2003 2004.s 29 - 29.

  • Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; Tollersrud, ole kristian; McSweeney, Sean; Hough, Edward. Structure of the Bovine Lysosomal a-Mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis. ESRF Highlights 2002 2003.s 12 - 13.

  • Leiros, Hanna-Kirsti S.. Comparison of psychrophilic and mesophilic trypsins : elucidating the basis of cold-adaptation. 1999.

  • Leiros, Hanna-Kirsti S.. Crystallographic studies of cationic trypsin from the North Atlantic salmon (Salmo salar). 1995.

  • Helland, Ronny; Berglund, Gunnar; Hansen, Lars Kr; Heimstad, Eldbjørg S.; Hordvik, Asbjørn; Leiros, Ingar; Leiros, Hanna-Kirsti S.; Os, vibeke; Outzen, Heidi; Willassen, Nils Peder; Smalås, Arne Oskar. Structure-Function Relation Studies of Enzymes from Cold Adapted Species. Higher European Research Course for Users of Large Experimental Systems (HERCULES) 1995-02-26 - 1995-04-07 1995.

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