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Bayer, Annette

Førsteamanuensis, Organisk kjemi
Kjemi




Forskningsprosjekter

Naturstoffer som framtidens legemidler

Dette projekt er en del at et national samarbeid mellom UiB, UiS, og NTNU (BIOSnet) og flere biologiske miljøer ved UiT. Syntese av artiske marine naturstoffer og deres derivater med formål å videreutvikle og kartlegge naturstoffenes biologiske aktivitet. Dette arbeidet omfatter methode utvikling, derivat syntese, men kan også utvides til syntese og anvendelse av molekylære prober.

* Framstilling av naturstoffer

* Utvikling av naturstoffer til legemiddelkandidater

Metal-katalyserte kjemiske transformasjoner for en bærekraftig utvikling

Dette projekt er en samarbeid med Dr. Kathrin Hopmann ved CTCC. Metall-katalyse med fokus mot utvikling av asymmetriske prossesser. Et framtidig mål er å utvikle nye metoder for omdannelse av karbon dioxid. Dette arbeidet omfatter:

* Metodeutvikling og syntese av nye ligander og deres metal komplekser

* Mekanistiske studier av iridium-katalyserte imine reduksjon

Strategier for bekjempelse av antibiotika resistens

Detter projekt er et samarbeid med Dr. Hanna-Kirsti Leiros ved Norstrukt, Dr. Ørjan Samuelsen ved UNN og Prof. Pål Rognved ved UiO. Syntese og design av nye inhibitorer for enzymer med høy klinisk relevans i forbindelse med antibiotika resistens.

* Utvikling av forbindelser som opphever antibiotikaresistens

* Metallo-beta-laktamase inhibitorer

* Fragment-basert inhibitor utvikling

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Arbeider i CRIStin


  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Hedberg, Christian; Bayer, Annette. A concise total synthesis of breitfussin A and B. Organic Letters 2015; Volum 17 (1). ISSN 1523-7060.s 122 - 125.s doi: 10.1021/ol503348n.

  • Demissie, Taye Beyene; Kostenko, Nataliya; Komorovsky, Stanislav; Repisky, Michal; Isaksson, Johan; Bayer, Annette; Ruud, Kenneth. Experimental and four-component relativistic DFT studies of tungsten carbonyl complexes. Journal of Physical Organic Chemistry 2015; Volum 28 (12). ISSN 0894-3230.s 723 - 731.s doi: 10.1002/poc.3476.

  • Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli. Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions. Tetrahedron 2015; Volum 71 (43). ISSN 0040-4020.s 8278 - 8284.s doi: 10.1016/j.tet.2015.09.003.

  • Hopmann, Kathrin Helen; Bayer, Annette. Enantioselective imine hydrogenation with iridium-catalysts: Reactions, mechanisms and stereocontrol. Coordination chemistry reviews 2014; Volum 268. ISSN 0010-8545.s 59 - 82.s doi: 10.1016/j.ccr.2014.01.023.

  • Hopmann, Kathrin Helen; Frediani, Luca; Bayer, Annette. Iridium-PHOX-mediated alkene hydrogenation: Isomerization influences the stereochemical outcome. Organometallics 2014; Volum 33 (11). ISSN 0276-7333.s 2790 - 2797.s doi: 10.1021/om5002843.

  • Melnes, Silje; Bayer, Annette; Gautun, Odd Reidar. Aryl N-methyliminodiacetic acid (MIDA) boronates from cyclotrimerization of ethynyl MIDA boronate with diynes. Tetrahedron 2013; Volum 69 (37). ISSN 0040-4020.s 7910 - 7915.s doi: 10.1016/j.tet.2013.07.027.

  • Kostenko, Nataliya; Eriksson, Anna Cecilia; Engqvist, Stig Olov Magnus; Villa Gonzalez, Susana; Bayer, Annette. Palladium(0)-Catalyzed Cross-Couplings of 2-Bromophosphinine. European Journal of Organic Chemistry 2013; Volum 2013 (22). ISSN 1434-193X.s 4756 - 4759.s doi: 10.1002/ejoc.201300710.

  • Lind, Karianne Fredenfeldt; Hansen, Espen; Østerud, Bjarne; Eilertsen, Karl-Erik; Bayer, Annette; Engqvist, Stig Olov Magnus; Leszczak, Kinga; Jørgensen, Trond Ø.; Andersen, Jeanette hammer. Antioxidant and Anti-Inflammatory Activities of Barettin. Marine Drugs 2013; Volum 11 (7). ISSN 1660-3397.s 2655 - 2666.s doi: 10.3390/md11072655.

  • Melnes, Silje; Bayer, Annette; Gautun, Odd Reidar. Cyclotrimerization of unsymmetrically bromo-substituted diynes: toward the synthesis of potential selective inhibitors of tyrosine kinase 2. Tetrahedron 2012; Volum 68 (40). ISSN 0040-4020.s 8463 - 8471.s doi: 10.1016/j.tet.2012.07.087.

  • Hopmann, Kathrin Helen; Bayer, Annette. On the Mechanism of Iridium-Catalyzed Asymmetric Hydrogenation of Imines and Alkenes: A Theoretical Study. Organometallics 2011; Volum 30 (9). ISSN 0276-7333.s 2483 - 2497.s doi: 10.1021/om1009507.

  • Endeshaw, Molla Mellese; Bayer, Annette; Hansen, Lars Kr; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of N-sulfinyl dienophiles with chiral bis(oxazoline)copper(II) and -zinc(II) triflates. European Journal of Organic Chemistry 2006. ISSN 1434-193X.s 5249 - 5259.s doi: 10.1002/ejoc.200600083.

  • Bayer, Annette. Aminohydroxylation of Carbon-Carbon Double Bonds. Springer 2004 ISBN 3-540-20983-2.s 43 - 71.

  • Bayer, Annette. Dihydroxylation of Carbon-Carbon Double Bonds. Springer 2004 ISBN 3-540-20983-2.s 21 - 42.

  • Bayer, Annette; Endeshaw, Molla Mellese; Gautun, Odd Reidar. Asymmetric hetero-Diels-Alder reactions of N-sulfinyl dienophiles using chiral bis(oxazoline)-copper(II) and -zinc(II) triflates. Journal of Organic Chemistry 2004; Volum 69. ISSN 0022-3263.s 7198 - 7205.

  • Källström, Klas; Hedberg, Christian; Brandt, Peter; Bayer, Annette; Andersson, Pher G.. Rationally designed ligands for asymmetric iridium-catalyzed hydrogenation of olefins. Journal of the American Chemical Society 2004; Volum 126. ISSN 0002-7863.s 14308 - 14309.

  • Hansen, Lars Kr.; Bayer, Annette; Gautun, Odd Reidar. (1R*,3R*,6S*)-3,6-Dihydro-3,6-dimethyl-2-(toluene-4-sulfonyl)-1(landa)4,2-thiazine 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2002; Volum E58. ISSN 1600-5368.s o198 - o199.

  • Bayer, Annette; Hansen, Lars Kr.; Gautun, Odd Reidar. Asymmetric Diels-Alder reactions of N-sulfinyl dienophiles using chiral Ti(IV)Lewis acids. Tetrahedron: asymmetry 2002; Volum 13. ISSN 0957-4166.s 2407 - 2415.

  • Hansen, Lars Kr.; Bayer, Annette; Gautun, Odd Reidar. Benzyl (1R*,3S*)-3,6-dihydro-3-methyl-1(landa)4,2-thiazine-2-carboxylate 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2002; Volum E58. ISSN 1600-5368.s o165 - o166.

  • Bayer, Annette; Gautun, Odd Reidar. Highly enantioselective hetero Diels-Alder reactions of N-sulfinyl dienophiles promoted by copper(II)- and zinc(II)-chiral bis(oxazoline) complexes. Tetrahedron: asymmetry 2001; Volum 12 (21). ISSN 0957-4166.s 2937 - 2939.

  • Hansen, Lars Kr; Bayer, Annette; Gautun, Odd Reidar. exo-3,6-Dihydro-3-methyl-2-(toluene-4-sulfonyl)-1_4,2-thiazine 1-oxide. Acta Crystallographica Section E: Structure Reports Online 2001; Volum E57. ISSN 1600-5368.s o1109 - o1110.

  • Bayer, Annette; Svendsen, John Sigurd. Substrate Binding in the Asymmetric Dihydroxylation Reaction � Investigation of the Stereoselectivity in the Dihydroxylation of Cs-Symmetric Divinylcarbinol Derivatives. European Journal of Organic Chemistry 2001. ISSN 1434-193X.s 1769 - 1780.

  • Bayer, Annette; Gautun, Odd Reidar. Asymmetric N-sulfinyl dienophile Diels-Alder cycloadditions using chiral Ti(IV)-based Lewis Acids. Tetrahedron Letters 2000; Volum 41. ISSN 0040-4039.s 3743 - 3746.

  • Henderson, RJ; Burkow, Ivan C.; Buzzi, M; Bayer, Annette. Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. Biochimica et Biophysica Acta 1998; Volum 1392. ISSN 0006-3002.s 309 - 319.

  • Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli. Total Synthesis of Tubastrine and 3-Dehydroxy Tubastrine. Organisk Kjemisk Vintermøte OKV31 2016-01-07 - 2016-01-10 2016.

  • Lund, Bjarte Aarmo; Ahkter, Sundus; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Structure-guided drug design for the antibiotic resistance enzyme OXA-48. 52nd Norwegian Biochemical Society Contact Meeting, Tromsø 2016-01-21 - 2016-01-24 2016.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. 51st Norwegian Biochemical Society Contact Meeting, Svalbard 2015-02-09 - 2015-02-13 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. Annual BioStruct Conference, The National graduate school in structural biology 2015-09-27 - 2015-09-30 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The fight against metallo-beta-lactamases and antibiotic resistance. BioStruct Open Day 2015-03-20 - 2015-03-20 2015.

  • Lund, Bjarte Aarmo; Guttormsen, Yngve; Christopeit, Tony; Bayer, Annette; Leiros, Hanna-Kirsti S.. Design of OXA-48 class D beta-lactamase inhibitors by fragment-based drug design. Annual BioStruct Conference, The National graduate school in structural biology 2015-08-27 - 2015-08-30 2015.

  • Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; Bayer, Annette; Hedberg, Christian. Total synthesis of breitfussin A and B.. 30. Organisk kjemisk vintermøte OKV30 2015-01-08 - 2015-01-11 2015.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue Trp228 and Tyr233 in the metallo-beta-lactamase GIM-1. 12th Beta-Lactamase Meeting 2014-06-28 - 2014-07-01 2014.

  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Bayer, Annette; Samulesen, Ørjan; Leiros, Hanna-Kirsti S.. The importance of residue W228 and Y233 in the metallo-beta-lactamase GIM-1. The Norwegian Biochemical Society (NBS) Contact Meeting 2014 2014-01-23 - 2014-01-26 2014.

  • Guttormsen, Yngve; Riedel, Jan; Bayer, Annette; Hedberg, Christian. Total Synthesis of Breitfussin A. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Paulsen, Marianne H.; Engqvist, Stig Olov Magnus; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Skagseth, Susann; Leszczak, Kinga; Akhter, Sundus; Bayer, Annette. Synthesis of potential metallo-beta-lactamase inhibitors. Organisk kjemisk vintermøte OKV29 2014-01-09 - 2014-01-12 2014.

  • Hansen, Jørn H; Bayer, Annette. Havets hemmeligheter blir medisiner. Dagavisen Nordlys 2013.

  • Ove Alexander, Høgmoen Åstrand; Edvardsen, Kine Susann Waade; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette; Rongved, Pål. Metallo-β-lactamase inhibitors. 2013.

  • Kostenko, Nataliya; Bayer, Annette. Exploring New Routes to 2-Functionalised Phosphinines. Organic Days XXIII 2012-06-12 - 2012-06-15 2012.

  • Melnes, Silje; Gautun, Odd Reidar; Bayer, Annette. "Studies towards the synthesis of potential therapeutic agents against the hematologic cancer multiple myeloma. 18th International Conference on Organic Synthesis 2010-08-01 - 2010-08-06 2010.

  • Endeshaw, Molla; Bayer, Annette; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of the N-sulfinyl dienophiles. CHIRALITY 2004, 16th International Symposium and Exhibits on Chirality 2004-06-11 - 2004-06-14 2004.

  • Endeshaw, Molla M; Bayer, Annette; Gautun, Odd Reidar. Catalytic asymmetric hetero Diels-Alder reactions of the N-sulfinyl dienophiles. Organisk Kjemisk Vintermøte 2003 2003-01-09 - 2003-01-12 2003.

  • Bayer, Annette. Asymmetric Hetero Diels-Alder Reactions of N-Sulfinyl Dienophiles Mediated by Chiral Lewis Acids. 2002 ISBN 82-497-0074-0.

  • Bayer, Annette; Gautun, Odd Reidar. N-Sulfinyl Compounds in Asymmetric Diels-Alder Reactions. 16. Organisk kjemisk vintermøte 2001-01-11 - 2001-01-14 2001.

  • Bayer, Annette; Gautun, Odd Reidar. Enantioselective Diels-Alder Reactions of N-Sulfinyl Compounds Promoted by Chiral Ti(IV)-Based Lewis Acids. 12. International Symposium on Homogenous Catalysis 2000-08-27 - 2000-09-01 2000.

  • Bayer, Annette; Gautun, Odd Reidar. N-Sulfinyl Compounds in Catalytic Asymmetric Diels-Alder Reactions. 14. Organisk kjemisk vintermøte 1999-01-07 - 1999-01-10 1999.

  • Bayer, Annette; Svendsen, John Sigurd. Catalytic Asymmetric Dihydroxylation of 1,5-Diphenyl-1,4-pentadien-3-ol Derivatives. A Model for Kinetic Resolution. 13. Organisk kjemisk vintermøte 1998-01-08 - 1998-01-11 1998.

  • Bayer, Annette; Svendsen, John Sigurd. Kinetic Resolution in the AD reaction. 12. Organisk kjemisk vintermøte 1997-01-09 - 1997-01-12 1997.

  • Henderson, RJ; Buzzi, M; Burkow, IC; Bayer, Annette; Park, MT. Inhibitory Effects of Long Chain n-3 Polyunsaturated Fatty Acids on the Desaturases and Elongases of Trout Liver Microsomes. 4. International Congress on Essential Fatty Acids and Eicosanoids 1997-07-20 - 1997-07-24 1997.

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