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Geir Villy Isaksen

Seniorforsker
Institutt for kjemi

Stillingsbeskrivelse:

Forskning, undervisning og formidling i kjemi og beregningskjemi med hovedfokus på biologisk kjemi, enzymevolusjon og katalyse. 




Undervisning

Har undervist en rekke kurs siden 2007 på blant annet allmenlærerutdanningen (ILP), fiskerihøgskolen (BFE) og institutt for kjemi (NT). Er for tiden involvert i følgende kurs ved UiT:

  • Introduksjon til kjemi og kjemisk biologi  (KJE-1001)
  • Molecular Modeling (PhD og master nivå)
  • Biomolecular Modeling(PhD og master nivå)

Arbeider i CRIStin


  • Socan, Jaka; Kazemi, Masoud; Isaksen, Geir Villy; Brandsdal, Bjørn Olav; Åqvist, Johan. Catalytic Adaptation of Psychrophilic Elastase. Biochemistry 2018; Volum 57 (20). ISSN 1520-4995.s 2984 - 2993.s doi: 10.1021/acs.biochem.8b00078.

  • Isaksen, Geir Villy; Åqvist, Johan; Brandsdal, Bjørn Olav. Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations. Biochemistry 2017; Volum 56 (1). ISSN 1520-4995.s 306 - 312.s doi: 10.1021/acs.biochem.6b00967.

  • Åqvist, Johan; Isaksen, Geir Villy; Brandsdal, Bjørn Olav. Computation of enzyme cold adaptation. Nature Reviews Chemistry 2017; Volum 1:0051. ISSN 2397-3358.s doi: 10.1038/s41570-017-0051.

  • Åqvist, Johan; Kazemi, Masoud; Isaksen, Geir Villy; Brandsdal, Bjørn Olav. Entropy and Enzyme Catalysis. Accounts of Chemical Research 2017; Volum 50 (2). ISSN 0001-4842.s 199 - 207.s doi: 10.1021/acs.accounts.6b00321.

  • Michetti, Davide; Brandsdal, Bjørn Olav; Bon, Davide; Isaksen, Geir Villy; Tiberti, Matteo; Papaleo, Elena. A comparative study of cold-and warmadapted Endonucleases A using sequence analyses and molecular Dynamics simulations. PLoS ONE 2017; Volum 12:e0169586 (2). ISSN 1932-6203.s 1 - 18.s doi: 10.1371/journal.pone.0169586.

  • Isaksen, Geir Villy; Hopmann, Kathrin Helen; Åqvist, Johan; Brandsdal, Bjørn Olav. Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase. Biochemistry 2016; Volum 55 (14). ISSN 1520-4995.s 2153 - 2162.s doi: 10.1021/acs.biochem.5b01347.

  • Isaksen, Geir Villy; Åqvist, Johan; Brandsdal, Bjørn Olav. Enzyme surface rigidity tunes the temperature dependence of catalytic rates. Proceedings of the National Academy of Sciences of the United States of America 2016; Volum 113 (28). ISSN 0027-8424.s 7822 - 7827.s doi: 10.1073/pnas.1605237113.

  • Isaksen, Geir Villy; Andberg, Tor Arne Heim; Åqvist, Johan; Brandsdal, Bjørn Olav. Qgui: A high-throughput interface for automated setup and analysis of free energy calculations and empirical valence bond simulations in biological systems. Journal of Molecular Graphics and Modelling 2015; Volum 60. ISSN 1093-3263.s 15 - 23.s doi: 10.1016/j.jmgm.2015.05.007.

  • Isaksen, Geir Villy; Åqvist, Johan; Brandsdal, Bjørn Olav. Protein surface softness is the origin of enzyme cold-adaptation of trypsin. PloS Computational Biology 2014; Volum 10:e1003813 (8). ISSN 1553-734X.s doi: 10.1371/journal.pcbi.1003813.

  • Karstad, Rasmus Tørnes; Isaksen, Geir Villy; Wynendaele, Evelien; Guttormsen, Yngve; De Spiegeleer, Bart; Brandsdal, Bjørn Olav; Svendsen, John Sigurd; Svenson, Johan. Targeting the S1 and S3 Subsite of Trypsin with Unnatural Cationic Amino Acids Generates Antimicrobial Peptides with Potential for Oral Administration. Journal of Medicinal Chemistry 2012; Volum 55 (14). ISSN 0022-2623.s 6294 - 6305.s doi: 10.1021/jm3002058.

  • Flaten, Gøril Eide; Kottra, Gabor; Stensen, Wenche; Isaksen, Geir Villy; Karstad, Rasmus Tørnes; Svendsen, John Sigurd; Daniel, Hannelore; Svenson, Johan. In Vitro Characterization of Human Peptide Transporter hPEPT1 Interactions and Passive Permeation Studies of Short Cationic Antimicrobial Peptides. Journal of Medicinal Chemistry 2011; Volum 54 (7). ISSN 0022-2623.s 2422 - 2432.s doi: 10.1021/jm1015704.

  • Karstad, Rasmus Tørnes; Isaksen, Geir; Brandsdal, Bjørn Olav; Svendsen, John Sigurd; Svenson, Johan. Unnatural Amino Acid Side Chains as S1, S1 ', and S2 ' Probes Yield Cationic Antimicrobial Peptides with Stability toward Chymotryptic Degradation. Journal of Medicinal Chemistry 2010; Volum 53 (15). ISSN 0022-2623.s 5558 - 5566.s doi: 10.1021/jm1006337.

  • Isaksen, Geir Villy. Computational Understanding of Biocatalytic Evolution to Extreme Environments. Forskeropphold 2019-02-05 - 2019-02-06 2019.

  • Isaksen, Geir Villy. Point charges.. KJE-3106 Biomolecular modelling 2019-03-18 - 2019-03-22 2019.

  • Isaksen, Geir Villy. Entropy Calculations in the PchB-catalyzed chorismate mutase reaction.. Uppsala Density Functional Theory meeting 2019-05-20 - 2019-05-22 2019.

  • Isaksen, Geir Villy; Åqvist, Johan; Brandsdal, Bjørn Olav. Computation of Enzyme Temperature Adaptation - Protein Surface Softness Regulates the Enthalpy-Entropy Balance.. ISQBP President’s meeting 2018 in Barcelona 2018-06-19 - 2018-06-21 2018.

  • Isaksen, Geir Villy. Empirical Valence Bond.. MOL910 - Biomolecular modelling 2018-03-19 - 2018-03-23 2018.

  • Isaksen, Geir Villy. SAM hydrolase (SVI-3) reaction mechanism. Wallenberg New Genes project meeting 2018-10-15 - 2018-10-16 2018.

  • Os, Vibeke; Isaksen, Geir Villy. Energiberegninger forklarer biologisk evolusjon. (fulltekst) 2015.

  • Isaksen, Geir Villy. Protein dynamics regulates enzyme enthalpy-entropy balance. 2015 ISBN 978-82-8236-178-1.

  • Isaksen, Geir Villy. Datasimuleringer baner vei for enzymdesign. Kjemi 2015; Volum 4. ISSN 0023-1983.s 4 - 7.

  • Isaksen, Geir Villy. Protein surface-softness is the origin of enzyme cold-adaptation.. Annual BioStruct conference 2013 2013-08-29 - 2013-09-01 2013.

  • Isaksen, Geir Villy; Isaksson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav. Structural studies of small cationic antimicrobial peptides by NMR and computer simulations have facilitated a refined pharmacophore model able to predict activity versus Staphylococcus aureus. SMASH 2011 2011-09-18 - 2011-09-21 2011.

  • Isaksen, Geir Villy; Brandsdal, Bjørn Olav. Membrane interaction mechanism for small antimicrobial peptides. The 1st annual BioStruct conference 2010-08-26 - 2010-08-29 2010.

  • Isaksen, Geir Villy; Karstad, Rasmus Tørnes; Isaksson, Johan Mattias; Svenson, Johan; Svendsen, John Sigurd; Brandsdal, Bjørn Olav. Structure of short cationic antimicrobial peptides and their interactions with membranes as revealed by MD simulations. ISB Winter School 2010 2010-12-07 - 2010-12-10 2010.

  • Isaksen, Geir Villy. Membrane interaction mechanisms for small antimicrobial peptides.. 1st annual BioStruct Conference 2010-08-27 - 2010-08-29 2010.