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Anett Kristin Larsen

Forsker
Institutt for medisinsk biologi




Forskningsinteresser

I prosjektet SECVIR undersøker vi om endotelcellene i leverens minste blodkar tar opp og fjerner virus fra blodbanen. Leverens sinusoidale endotelceller (LSEC) er viktige renovasjons- og forsvarsceller som fjerner avfallsmolekyler og mikrobielle molekyler fra blodbanene. LSEC utgjør kroppens hovedpopulasjon av scavenger endotelceller, som er en spesiell type endotelceller med svært stor endocytoseaktivitet. Vårt hovedmål er å undersøke om ulike typer virus elimineres via leveren ved hjelp av de spesialiserte LSEC og dermed øke forståelsen for hvilken rolle disse cellene har i kroppens forsvar mot virusinfeksjoner. 

Dette arbeidet er en veldig spennende utvidelse av min forskningsinteresse som er cellulære mekanismer ved infeksjonssykdommer, inkludert zoonotiske sykdommer. I min post doc periode hadde jeg spesielt fokus på cellebiologi og immunologi hos arktiske dyrearter, med utvikling av infeksjonsmodeller i primære cellekulturer isolert fra aktuelle ville Arktiske dyr. Jeg er også interessert i kombinerte effekter av klima- og miljøforandringer på helse og evnen til å bekjempe sykdom.

 

I tillegg til dette er jeg glad i å formidle forskning til store og små.

 

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CV

2014-2016        

Post-doctoral researcher at the University of Tromsø (UiT) – the Arctic University of Norway, Department of Arctic and Marine Biology, Research Group of Arctic Infection Biology

2011-2013        

Post-doctoral researcher at the Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, Section of Arctic Veterinary Medicine

2005-2010          

PhD-position in medical biology at the University Hospital of North Norway, Department of Occupational- and Environmental Medicine, Tromsø. In collaboration with the University of Tromsø, Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, Tromsø, Norway.

Title: Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells

2004-2005       

Inspector at the Norwegian Food Safety Authority, District Office for Salten, Bodø

2004     

Veterinarian, small animal clinic – Dyret i Sentrum, Narvik, Norway 

1998-2004          

Cand.Med.Vet at the Norwegian School of Veterinary Sciences, Oslo, Norway

Arbeider i CRIStin


  • Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein. Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Frontiers in Genetics 2019; Volum 10:794. ISSN 1664-8021.s 1 - 18.s doi: 10.3389/fgene.2019.00794.

  • Nymo, Ingebjørg Helena; Rødven, Rolf; Beckmen, Kimberlee B.; Larsen, Anett Kristin; Tryland, Morten; Quakenbush, Lori; Godfroid, Jacques. Brucella antibodies in alaskan true seals and eared seals — two different stories. Frontiers in Veterinary Science 2018; Volum 5 (8). ISSN 2297-1769.s doi: 10.3389/fvets.2018.00008.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Seppola, Marit; Rødven, Rolf; Jiménez de Bagüés, María Pilar; Al Dahouk, Sascha; Godfroid, Jacques. Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod. Frontiers in Microbiology 2018; Volum 9 (2963). ISSN 1664-302X.s doi: 10.3389/fmicb.2018.02963.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Seternes, Ole Morten; Bang, Berit. Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549). Toxicology and industrial health 2016; Volum 32 (11). ISSN 0748-2337.s 1866 - 1874.s doi: 10.1177/0748233715590914.

  • Nymo, Ingebjørg Helena; Seppola, Marit; Sascha, Al Dahouk; Bakkemo, Katrine Ryvold Arnesen; Jiménez de Bagüés, María Pilar; Godfroid, Jacques; Larsen, Anett Kristin. Experimental challenge of atlantic cod (Gadus morhua) with a brucella pinnipedialis strain from hooded seal (Cystophora cristata). PLOS ONE 2016; Volum 11 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0159272.

  • Larsen, Anett Kristin; Godfroid, Jacques; Nymo, Ingebjørg Helena. Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells. Acta Veterinaria Scandinavica 2016; Volum 58 (9). ISSN 1751-0147.s doi: 10.1186/s13028-016-0188-5.

  • Godfroid, Jacques; De Bolle, Xavier; Roop, R. Martin I.I.; O'Callaghan, David; Tsolis, Renée M.; Baldwin, Cynthia L.; Santos, Renato L.; McGiven, John A.; Olsen, Steven C.; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Al Dahouk, Sascha; Letesson, Jean-Jacques. The quest for a true One Health perspective of brucellosis. Rev Sci Tech Off Int Epizoot 2014; Volum 33 (2). ISSN 0253-1933.s 521 - 538.

  • Nymo, Ingebjørg Helena; Tryland, Morten; Åsbakk, Kjetil; Godfroid, Jacques; Larsen, Anett Kristin. Brucella-infeksjoner hos sjøpattedyr - fortsatt ubesvarte spørsmål. Norsk Veterinærtidsskrift 2014; Volum 126 (5). ISSN 0332-5741.s 455 - 462.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Winberg, Jan-Olof; Seternes, Ole Morten; Bang, Berit. Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. Food and Chemical Toxicology 2014; Volum 69. ISSN 0278-6915.s 303 - 311.s doi: 10.1016/j.fct.2014.04.030.

  • Nymo, Ingebjørg Helena; Godfroid, Jacques; Åsbakk, Kjetil; Larsen, Anett Kristin; Das Neves, Carlos G; Rødven, Rolf; Tryland, Morten. A protein A/G indirect enzyme-linked immunosorbent assay for the detection of anti-Brucella antibodies in Arctic wildlife. Journal of Veterinary Diagnostic Investigation 2013; Volum 25 (3). ISSN 1040-6387.s 369 - 375.s doi: 10.1177/1040638713485073.

  • Larsen, Anett Kristin; Kristiansen, kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit. Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. BMC Research Notes 2013; Volum 6. ISSN 1756-0500.s 281 - .s doi: 10.1186/1756-0500-6-281.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Briquemont, Benjamin; Sørensen, Karen Kristine; Godfroid, Jacques. Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells. PLOS ONE 2013; Volum 8 (12). ISSN 1932-6203.s doi: 10.1371/journal.pone.0084861.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Boysen, Preben; Tryland, Morten; Godfroid, Jacques. Entry and Elimination of Marine Mammal Brucella spp. by Hooded Seal (Cystophora cristata) Alveolar Macrophages In Vitro. PLOS ONE 2013; Volum 8 (7). ISSN 1932-6203.s doi: 10.1371/journal.pone.0070186.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Kishimura, Hideki; Rudenskaya, Galina N; Bang, Berit. Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling. Toxicological & Environmental Chemistry 2011; Volum 93 (10). ISSN 0277-2248.s 1991 - 2011.s doi: 10.1080/02772248.2011.614380.

  • Bang, Berit; Larsen, Merethe; Larsen, Anett Kristin; Aasmoe, lisbeth. Proteases from Salmon Stimulate IL-8 in Airway Epithelial Cells. Journal of Toxicology and Environmental Health, Part A 2009; Volum 72 (9). ISSN 1528-7394.s 571 - 573.s doi: 10.1080/15287390902733499.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Aasmoe, lisbeth; Bang, Berit. Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2. Toxicology and Applied Pharmacology 2008; Volum 230. ISSN 0041-008X.s 276 - 282.s doi: 10.1016/j.taap.2008.02.019.

  • Sanchez Romano, Javier; Tryland, Morten; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Sørensen, Karen Kristine. Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus. 2019 ISBN 978-82-8266-163-8.

  • Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein. Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Conference talk. 20th International Symposium on Pollutant Responses in Marine Organisms 2019-05-18 - 2019-05-22 2019.

  • Olsvik, Pål A.; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Sanden, Monica; Kristensen, Torstein. Agricultural pesticides in aquafeeds might harm wild fish feeding on leftover pellets near fish farms.. 20th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 20) 2019-05-19 - 2019-05-22 2019.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. Regional Helsekonferanse 2016-11-02 - 2016-11-03 2016.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. EAACI 2016 2016-06-12 - 2016-06-16 2016.

  • Godfroid, Jacques; Nymo, Ingebjørg Helena; Larsen, Anett Kristin; Åsbakk, Kjetil; Josefsen, Terje D.. Meldepliktige sykdommer hos rein. Norsk Veterinærtidsskrift 2014; Volum 126 (2). ISSN 0332-5741.s 243 - 249.

  • Nymo, Ingebjørg Helena; Tryland, Morten; Godfroid, Jacques; Larsen, Anett Kristin; Lie, Elisabeth; Letesson, Jean-Jacques. Brucella pinnipedialis in hooded seals (Cystophora cristata): infection biology and effect of PCB 153 exposure under experimental conditions. 2013 ISBN 978-82-7725-254-4.

  • Beckmen, Kimberly; Nymo, Ingebjørg Helena; Tryland, Morten; Åsbakk, Kjetil; Larsen, Anett Kristin; Godfroid, Jacques; Dau, Jim; Rødven, Rolf. Spatio-temporal trends in prevalence of anti-Brucella antibodies in barren-ground caribou (Rangifer tarandus granti) in Alaska - an example of enzootic equilibrium. 66th BRucella research conference 2013-12-07 - 2013-12-08 2013.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Briquemont, Benjamin; Sørensen, Karen Kristine; Godfroid, Jacques. Brucella pinnipedialis hooded seal strain in cell models. 66th Brucella research conference 2013-12-07 - 2013-12-08 2013.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Boysen, Preben; Tryland, Morten; Godfroid, Jacques. Entry of hooded seal (Cystophora cristata) alveolar macrophages by marine Brucella spp. 65th Brucella research conference 2012-12-01 - 2012-12-02 2012.

  • Larsen, Anett Kristin; Nymo, Ingebjørg Helena; Sørensen, Karen Kristine; Tryland, Morten; Godfroid, Jacques. Brucella pinnipedialis hooded seal (Cystophora cristata) strain invades human macrophages in culture. 61st International Conference of the WDA/10th Biennial Conference of the EWDA 2012-07-23 - 2012-07-27 2012.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells. Organic Dust Tromsø Symposium 2011-04-11 - 2011-04-13 2011.

  • Larsen, Anett Kristin; Bang, Berit; Seternes, Ole Morten. Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells. 2010 ISBN 978-82-7589-284-1.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549). XXVI Congress of the European Academy of Allergology and Clinical Immunology 2007-06-21 - 2007-06-23 2007.

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