Forskningsinteresser

Biophysical characterization of enzymes and kinases involved in neurodegenerative diseases 

Arbeider i CRIStin


  • Halsør, Marie-Josée Haglund; Rothweiler, Ulli; Altermark, Bjørn; Ræder, Inger Lin Uttakleiv. The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer. Acta Crystallographica Section D: Structural Biology 2019; Volum 75. ISSN 2059-7983.s 90 - 100.s doi: 10.1107/S2059798318017047.

  • Helland, Ronny; Bjørkeng, Eva katrin; Rothweiler, Ulli; Sydnes, Magne Olav; Pampanin, Daniela Maria. The crystal structure of haemoglobin from Atlantic cod. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2019; Volum F75 (8). ISSN 1744-3091.s 537 - 542.s doi: 10.1107/S2053230X1900904X.

  • Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. Journal of Medicinal Chemistry 2018; Volum 61 (17). ISSN 0022-2623.s 7560 - 7572.s doi: 10.1021/acs.jmedchem.7b01847.

  • Tuveng, Tina Rise; Rothweiler, Ulli; Udatha, D.B.R.K. Gupta; Vaaje-Kolstad, Gustav; Smalås, Arne O.; Eijsink, Vincent. Structure and function of a CE4 deacetylase isolated from a marine environment. PLoS ONE 2017; Volum 12 (11). ISSN 1932-6203.s doi: 10.1371/journal.pone.0187544.

  • Rothweiler, Ulli; Stensen, Wenche; Brandsdal, Bjørn Olav; Isaksson, Johan; Leeson, Frederick Alan; Engh, Richard Alan; Svendsen, John Sigurd Mjøen. Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules. Journal of Medicinal Chemistry 2016; Volum 59 (21). ISSN 0022-2623.s 9814 - 9824.s doi: 10.1021/acs.jmedchem.6b01086.

  • Rothweiler, Ulli; Eriksson, Jonas; Stensen, Wenche; Leeson, Frederick Alan; Engh, Richard Alan; Svendsen, John Sigurd. Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors. European Journal of Medicinal Chemistry 2015; Volum 94. ISSN 0223-5234.s 140 - 148.s doi: 10.1016/j.ejmech.2015.02.035.

  • Gani, Osman A.B.S.M.; Thakkar, Balmukund; Narayanan, Dilip; Alam, Kazi Asraful; Kyomuhendo, Peter; Rothweiler, Ulli; Tello-Franco, Veronica; Engh, Richard Alan. Assessing protein kinase target similarity: Comparing sequence, structure, and cheminformatics approaches. (fulltekst) Biochimica et Biophysica Acta - Proteins and Proteomics 2015; Volum 1854 (10). ISSN 1570-9639.s 1605 - 1616.s doi: 10.1016/j.bbapap.2015.05.004.

  • Alexeeva, Marina; Åberg, espen; Engh, Richard Alan; Rothweiler, Ulli. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 1207 - 1215.s doi: 10.1107/S1399004715005106.

  • Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S.. Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (11). ISSN 0907-4449.s 3043 - 3056.s doi: 10.1107/S1399004714021099.

  • Åberg, espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli; Oliveira, Taiana Maia De; Engh, Richard Alan. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry (Print) 2012; Volum 393 (10). ISSN 1431-6730.s 1121 - 1129.s doi: 10.1515/hsz-2012-0248.

  • Rothweiler, Ulli; Åberg, espen; Johnson, Kenneth; Hansen, Tom Egil; Jørgensen, Jorunn B; Engh, Richard Alan. p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation. Journal of Molecular Biology 2011; Volum 411 (2). ISSN 0022-2836.s 474 - 485.s doi: 10.1016/j.jmb.2011.06.013.

  • Orth, Michael; Mayer, Bernd; Rehm, Kinga; Rothweiler, Ulli; Heidmann, Doris; Holak, Tad A; Stemmann, Olaf. Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO Journal 2011; Volum 30 (14). ISSN 0261-4189.s 2868 - 2880.

  • Rothweiler, Ulli; Czarna, Anna Lucja; Krajewski, Marcin; Ciombor, Jolanta; Kalinski, Cédric; Khazak, Vladimir; Ross, Günther; Skobeleva, Natalia; Weber, Lutz; Holak, Tad A. Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction. ChemMedChem 2008. ISSN 1860-7179.

  • Rothweiler, Ulli; Czarna, Anna Lucja; Weber, Lutz; Popowicz, Grzegorz; Brongel, Kinga; Kowalska, Kaja; Orth, Michael; Stemmann, Olaf; Holak, Tad A. NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins. Journal of Medicinal Chemistry 2008. ISSN 0022-2623.

  • Krajewski, Marcin; Rothweiler, Ulli; D'Silva, Loyola; Majumdar, Sudipta; Klein, Christian; Holak, Tad A. An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments.. Journal of Medicinal Chemistry 2007. ISSN 0022-2623.

  • Popowicz, Grzegorz; Czarna, Anna Lucja; Rothweiler, Ulli; Szwagierczak, Aleksandra; Krajewski, Marcin; Weber, Lutz; Holak, Tad A. Molecular Basis for the Inhibition of p53 by Mdmx. Cell Cycle 2007. ISSN 1538-4101.

  • D'Silva, Loyola; Ozdowy, Przemyslaw; Krajewski, Marcin; Rothweiler, Ulli; Singh, Mahavir; Holak, Tad A. Monitoring the Effects of Antagonists on Protein−Protein Interactions with NMR Spectroscopy. Journal of the American Chemical Society 2005. ISSN 0002-7863.

  • Krajewski, Marcin; Ozdowy, Przemyslaw; D'Silva, Loyola; Rothweiler, Ulli; Holak, Tad A. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nature Medicine 2005. ISSN 1078-8956.

  • Gurung, Man Kumari; Berg, Tor Olav; Halsør, Marie-Josée Haglund; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Rothweiler, Ulli; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. Efficient production of sialic acids- Using enzymes for biomass conversion. Eurocarb 2017 2017-07-02 - 2017-07-06 2017.

  • Gurung, Man Kumari; Berg, Tor Olav; Halsør, Marie-Josée Haglund; Altermark, Bjørn; Leiros, Ingar; Helland, Ronny; Rothweiler, Ulli; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. Efficient production of sialic acids- Using enzymes for biomass conversion. BIOPROSP2017 2017-03-08 - 2017-03-10 2017.

  • Pierechod, Marcin Miroslaw; Rothweiler, Ulli; de Oliveira, Taianá Maia. The structure of Salinibacter ruber Single‐Strand Binding protein reveals a novel, octameric architecture of bacterial SSB proteins. Norwegian Biochemical Society contact meeting 2016-01-21 - 2016-01-23 2016.

  • Alam, Kazi Asraful; Rothweiler, Ulli; Engh, Richard Alan. Static and dynamic interactions between the glycine-rich loop of protein kinases and ATP site inhibitors. Norwegian Biochemical Society contact meeting 2016-01-21 - 2016-01-24 2016.

  • Berg, Tor Olav; Halsør, Marie-Josée Haglund; Gurung, Man Kumari; Altermark, Bjørn; Leiros, Ingar; Rothweiler, Ulli; Helland, Ronny; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv. From marine rest raw materials to sialic acids: Using enzymes for biomass conversion. Frontiers in Sialic Acid Research 2016-04-23 - 2016-04-25 2016.

  • Rothweiler, Ulli. DYRK1A-PKC412 complex - disulfide-bridge formation with an anomalous catalytic loop HRD(HCD) cysteine. Contact Meeting 2016 2016-01-21 - 2016-01-24 2016.

  • Alexeeva, Marina; Åberg, espen; Engh, Richard Alan; Rothweiler, Ulli. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.. Contact Meeting 2016 2016-01-21 - 2016-01-24 2016.