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Rothweiler, Ulli


Forsker
Kjemi


Telefon: 776 20850
Mobil jobb / Mobil privat: /
Epost : ulli.rothweiler@uit.no
Campus: Tromsø
Kontor/besøksadresse : FPARK G 230 / Forskningsparken 3
Funksjon : Forsker, Strukturkjemi, Norstruct

Arbeider i CRIStin

  • Rothweiler, Ulli; Eriksson, Jonas; Stensen, Wenche; Leeson, Frederick; Engh, Richard Alan; Svendsen, John Sigurd. Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors. European Journal of Medicinal Chemistry 2015. ISSN 0223-5234.

  • Alexeeva, Marina; Åberg, espen; Engh, Richard Alan; Rothweiler, Ulli. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 1207 - 1215.s doi: 10.1107/S1399004715005106.

  • Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S.. Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallographica Section D: Biological Crystallography 2014; Volum 70 (11). ISSN 0907-4449.s 3043 - 3056.s doi: 10.1107/S1399004714021099.

  • Åberg, espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli; Oliveira, Taiana Maia De; Engh, Richard Alan. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry (Print) 2012; Volum 393 (10). ISSN 1431-6730.s 1121 - 1129.s doi: 10.1515/hsz-2012-0248.

  • Rothweiler, Ulli; Åberg, espen; Johnson, Kenneth; Hansen, Tom Egil; Jørgensen, Jorunn B; Engh, Richard Alan. p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation. Journal of Molecular Biology 2011; Volum 411 (2). ISSN 0022-2836.s 474 - 485.s doi: 10.1016/j.jmb.2011.06.013.

  • Orth, Michael; Mayer, Bernd; Rehm, Kinga; Rothweiler, Ulli; Heidmann, Doris; Holak, Tad A; Stemmann, Olaf. Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO Journal 2011; Volum 30 (14). ISSN 0261-4189.s 2868 - 2880.

  • Rothweiler, Ulli; Czarna, Anna Lucja; Krajewski, Marcin; Ciombor, Jolanta; Kalinski, Cédric; Khazak, Vladimir; Ross, Günther; Skobeleva, Natalia; Weber, Lutz; Holak, Tad A. Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction. ChemMedChem 2008. ISSN 1860-7179.

  • Rothweiler, Ulli; Czarna, Anna Lucja; Weber, Lutz; Popowicz, Grzegorz; Brongel, Kinga; Kowalska, Kaja; Orth, Michael; Stemmann, Olaf; Holak, Tad A. NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins. Journal of Medicinal Chemistry 2008. ISSN 0022-2623.

  • Krajewski, Marcin; Rothweiler, Ulli; D'Silva, Loyola; Majumdar, Sudipta; Klein, Christian; Holak, Tad A. An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments.. Journal of Medicinal Chemistry 2007. ISSN 0022-2623.

  • Popowicz, Grzegorz; Czarna, Anna Lucja; Rothweiler, Ulli; Szwagierczak, Aleksandra; Krajewski, Marcin; Weber, Lutz; Holak, Tad A. Molecular Basis for the Inhibition of p53 by Mdmx. Cell Cycle 2007. ISSN 1538-4101.

  • D'Silva, Loyola; Ozdowy, Przemyslaw; Krajewski, Marcin; Rothweiler, Ulli; Singh, Mahavir; Holak, Tad A. Monitoring the Effects of Antagonists on Protein−Protein Interactions with NMR Spectroscopy. Journal of the American Chemical Society 2005. ISSN 0002-7863.

  • Krajewski, Marcin; Ozdowy, Przemyslaw; D'Silva, Loyola; Rothweiler, Ulli; Holak, Tad A. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nature Medicine 2005. ISSN 1078-8956.





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