Disputas – Master in Applied Genetics Mehrdad Rakaee

Master in Applied Genetics Mehrdad Rakaee disputerer for ph.d.-graden i helsevitenskap og vil offentlig forsvare avhandlingen:

 

“Immune Infiltration and Clinical Outcome in Non-Small Cell Lung Cancer”

Kort sammendrag av avhandlingen:

In Norway, lung cancer is the second and third most common cancer in men and women, respectively. During cancer development, interaction between the tumor and its surrounding environment shapes the destiny of the tumor cells. Immune cells will in many cases inhibit tumor growth. Neutrophils, lymphocytes and macrophages are the most predominant immune cells in tumor tissues. This thesis aims to examine associations between these cells and clinical outcome of 553 non-small cell lung cancer patients. Rakaee and coworkers found that patients with high level of neutrophils (in squamous cell carcinoma histology), lymphocytes and macrophages (any phenotype including M1 & M2) exhibit improved cause-specific and overall mortality and have lower risk of disease progression. These results will be validated in an ongoing clinical trial aiming at implementation of the most promising immune markers in routine clinical practice. Ultimately, helping physicians predict prognosis and improve treatment decisions.

Veiledere

Hovedveileder førsteamanuensis Thomas Kilvær

Biveileder professor Tom Dønnem

Biveileder professor Lill-Tove Rasmussen Busund

 

Bedømmelseskomiteen

Førsteamanuensis Maria Planck, Lund Universitet, Sverige – 1. opponent

Overlege/ph.d. Maria Paula Ramnefjell, Universitetet i Bergen/Haukeland Universitetssykehus – 2. opponent

Professor Bjørn Odvar Eriksen, UiT – Norges arktiske universitet – leder av komité

 

Disputasleder

Professor Terje Larsen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, Universitetet i Tromsø – Norges arktiske universitet

 

Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted: Cancer biomarkers - from identification to clinical implementation”

Når: 12.03.19 kl 10.15–16.00
Hvor: Auditorium Cortex
Sted: Tromsø
Målgruppe: Ansatte, Studenter, Gjester / eksterne, Inviterte, Enhet
Kontakt: Kristin Lagesen
E-post: kristin.lagesen@uit.no
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