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Institutt for klinisk medisin ole.l.brekke@uit.no

Ole Lars Brekke


Professor II


  • Kristin Nygaard-Odeh, Hedda Soloy-Nilsen, Magnhild Gangsøy Kristiansen, Ole Lars Brekke, Tom Eirik Mollnes, Michael Berk m.fl.:
    Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy
    Acta Neuropsychiatrica 2024 DOI
  • Åse Emblem, Erik Knutsen, Tor Erik Jørgensen, Hilde Fure, Steinar Daae Johansen, Ole Lars Brekke m.fl.:
    Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene
    Non-coding RNA 2022 ARKIV / DOI
  • Erik Waage Nielsen, Yoav Miller, Ole Lars Brekke, Joost Grond, Anh Hoang Duong, Hilde Fure m.fl.:
    A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment
    Frontiers in Immunology 2022 ARKIV / DOI
  • Hedda Soløy-Nilsen, Kristin Nygård-Odeh, Magnhild Gangsøy Kristiansen, Ole Lars Brekke, Tom Eirik Mollnes, Solveig Merete Klæbo Reitan m.fl.:
    Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
    BMC Psychiatry 2022 ARKIV / DOI
  • Tom Eirik Mollnes, Benjamin Storm, Ole Lars Brekke, Per Nilsson, John D. Lambris :
    Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research – 20 years of experience and future perspectives
    Seminars in Immunology 2022 ARKIV / DOI
  • Elin Storjord, Stella Airila-Månsson, Katarzyna Karlsen, Martin Ragnar Skjerve Madsen, Jim André Dahl, Anne Landsem m.fl.:
    Dental and Periodontal Health in Acute Intermittent Porphyria
    Life 2022 ARKIV / DOI
  • Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Bård Ove Karlsen m.fl.:
    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
    Frontiers in Immunology 2022 ARKIV / DOI
  • Benjamin Storm, Dorte Christiansen, Hilde Fure, Judith K Ludviksen, Corinna Lau, John D. Lambris m.fl.:
    Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
    Journal of Immunology 2021 ARKIV / DOI
  • Per Nilsson, Christina Johnson, Huy Quang Quach, Alex Macpherson, Oliver Durrant, Soeren Pischke m.fl.:
    A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity
    Journal of Immunology 2021 ARKIV / DOI
  • Frid Sofie Lichtwarck Bjugn, Elin Storjord, Roy Morten Kristensen, Ole-Lars Brekke :
    Safe usage of bicalutamide and goserelin in a male patient with acute intermittent porphyria and prostate cancer
    Scandinavian Journal of Urology 2019 DOI
  • Ole-Lars Brekke, Dorte Christiansen, Aymric Kisserli, Hilde Fure, Jim André Dahl, Béatrice Donvito m.fl.:
    Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood
    Molecular Immunology 2019 ARKIV / DOI
  • Caroline S. Gravastrand, Bjørg Steinkjer, Bente Halvorsen, Anne Landsem, Mona Skjelland, Eva Astrid Jacobsen m.fl.:
    Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
    Journal of Immunology 15. august 2019 FULLTEKST / OMTALE / ARKIV / DOI
  • Elin Storjord, Jim André Dahl, Anne Landsem, Judith K Ludviksen, Marlene Karlsen, Bård Ove Karlsen m.fl.:
    Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway.
    Molecular Genetics and Metabolism 2018 ARKIV / DOI
  • Anne Landsem, Hilde Fure, Judith K Ludviksen, Dorte Christiansen, Corinna Lau, Monica Dammen Mathisen m.fl.:
    Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
    Clinical and Experimental Immunology 2018 ARKIV / DOI
  • Randolf Inge Hardersen, Terje Enebakk, Dorte Christiansen, Grete Bergseth, Ole-Lars Brekke, Tom Eirik Mollnes m.fl.:
    Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) ? an ex vivo study with blood from a C5-deficient individual
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2018 ARKIV / DOI
  • Espen Waage Skjeflo, Dorte Christiansen, Hilde Fure, Judith K Ludviksen, Trent M. Woodruff, Terje Espevik m.fl.:
    Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation
    Journal of Thrombosis and Haemostasis 2018 ARKIV / DOI
  • Ina Isabella Høiland, Robin Amanda Liang, Kristian Hindberg, Nadezhda Latysheva, Ole-Lars Brekke, Tom Eirik Mollnes m.fl.:
    Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism
    Thrombosis Research 2018 ARKIV / DOI
  • Linda Torrissen Hennø, Elin Storjord, Dorte Christiansen, Grete Bergseth, Judith K Ludviksen, Hilde Fure m.fl.:
    Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines ? Consequences for defining reference values in healthy humans
    Cytokine 2017 ARKIV / DATA / DOI
  • Elin Storjord, Jim André Dahl, Anne Landsem, Hilde Fure, Judith K Ludviksen, Sandy Goldbeck-Wood m.fl.:
    Systemic inflammation in acute intermittent porphyria:a case–control study
    Clinical and Experimental Immunology 15. desember 2016 DOI
  • Caroline Gravastrand, Shamal Hamad, Hilde Fure, Bjørg Steinkjer, Liv Ryan, José Oberholzer m.fl.:
    Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
    Acta Biomaterialia 2017 ARKIV / FULLTEKST / DOI
  • Mathias Pontus Ørning, Kine Samset Hoem, Abba Elizabeth Coron, Gudmund Skjåk-Bræk, Tom Eirik Mollnes, Ole Lars Brekke m.fl.:
    Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
    Journal of Controlled Release 10. mai 2016 ARKIV / FULLTEKST / DOI
  • Anne Landsem, Hilde Fure, Tom Eirik Mollnes, Erik Waage Nielsen, Ole Lars Brekke :
    C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry
    Thrombosis Research 2016 DOI
  • Svein Barene, Andreas Holtermann, Harald Oseland, Ole Lars Brekke, Peter Krustrup :
    Effects on muscle strength, maximal jump height, flexibility and postural sway after soccer and Zumba exercise among female hospital employees: A 9-month randomized controlled trial
    Journal of Sports Sciences 05. februar 2016 DATA / DOI
  • Espen Waage Skjeflo, Caroline Sagatun, Knut Dybwik, Sturla Aam, Sven Haakon Urving, Miles A. Nunn m.fl.:
    Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
    Critical Care 2015 ARKIV / DOI
  • Randi Hallstensen, Grete Bergseth, Stian Foss, Steinar Jæger, Thobias Gedde-Dahl, jan Holt m.fl.:
    Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
    Immunobiology 2015 ARKIV / DOI
  • Corinna Lau, Ole Kristoffer Olstad, Marit Holden, Ståle Nygård, Hilde Fure, Knut Tore Lappegård m.fl.:
    Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
    Genomics Data 2015 ARKIV / DOI
  • Anne Landsem, Hilde Fure, Dorte Christiansen, Erik Waage Nielsen, Bjarne Østerud, Tom Eirik Mollnes m.fl.:
    The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood
    Clinical and Experimental Immunology 2015 DOI
  • Corinna Lau, Ståle Nygård, Hilde Fure, Ole Kristoffer Olstad, Marit Holden, Knut Tore Lappegård m.fl.:
    CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
    PLOS ONE 2015 ARKIV / DOI
  • Svein Barene, Peter Krustrup, Ole Lars Brekke, Andreas Holtermann :
    Soccer and Zumba as health-promoting activities among female hospital employees: A 40-weeks cluster randomised intervention study
    Journal of Sports Sciences 2014 FULLTEKST / DOI
  • Svein Barene, Peter Krustrup, Sarah Jackman, Ole Lars Brekke, Andreas Holtermann :
    Do soccer and Zumba exercise improve fitness and indicators of health among female hospital employees? A 12-week RCT
    Scandinavian Journal of Medicine & Science in Sports 10. september 2013 FULLTEKST / DOI
  • Bjørg Evjenth, Tonje Elisabeth Hansen, Ole Lars Brekke, Jan Holt :
    Establishing IMMULITE® 2000 cut-off values for serum allergen-specific immunoglobulin and exploring their relationship to exhaled nitric oxide
    Acta Paediatrica 2014 ARKIV / DOI
  • Eivind Samstad, Nathalie Niyonzima, Stig Haugset Nymo, Marie Hjelmseth Aune, Liv Ryan, Siril Skaret Bakke m.fl.:
    Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
    Journal of Immunology 2014 DOI
  • Ole Lars Brekke, Knut-Christian Waage, Dorte Christiansen, Hilde Fure, H Qu, John D. Lambris m.fl.:
    The Effects of Selective Complement and CD14 Inhibition on the E. coli -Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood
    Springer Science+Business Media B.V. 2013 DOI
  • Anne Landsem, Erik Waage Nielsen, Hilde Fure, Dorte Christiansen, Judith K Ludviksen, J.D. Lambris m.fl.:
    C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood
    Clinical and Experimental Immunology 2013 DOI
  • Anne Mari Rokstad, Ole Lars Brekke, Bjørg Steinkjer, Liv Ryan, Gabriela Kolláriková, Berit Løkensgard Strand m.fl.:
    The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
    Biomaterials 24. oktober 2013 DOI
  • Corinna Lau, Kristin Støen Gunnarsen, Lene Støkken Høydahl, Jan Terje Andersen, Gøril Berntzen, Anne Margrethe Pharo m.fl.:
    Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation
    Journal of Immunology 23. september 2013 FULLTEKST / ARKIV / DOI
  • Ole Lars Brekke, Joost Grond, Anne Landsem, Dorte Christiansen, Judith K Ludviksen, Corinna Lau m.fl.:
    Effects of complement C3, C5 and CD14 inhibitors on bacterial survival and thromboinflammation induced by two different live E.coli-strains in human whole blood
    2022
  • Elin Storjord, Linda Torrissen Hennø, Tom Eirik Mollnes, Ole-Lars Brekke :
    Analyse av cytokiner
    Tidsskrift for Den norske legeforening 2020 DOI
  • Caroline S. Gravastrand, Bjørg Steinkjer, Bente Halvorsen, Anne Landsem, Mona Skjelland, Eva Astrid Jacobsen m.fl.:
    Cholesterol crystals induce thromboinflammation
    2019
  • Anne Mari Rokstad, Caroline S. Gravastrand, Bente Halvorsen, Bjørg Steinkjer, Mona Skjelland, Eva Astrid Jacobsen m.fl.:
    Cholesterol crystals induce coagulation that can be prevented by targeting complement
    2018
  • Caroline Gravastrand, Bjørg Steinkjer, Hilde Fure, Liv Ryan, Catia Martins, Tom Eirik Mollnes m.fl.:
    Cholesterol crystals induce coagulation activation in a complement-dependent manner
    2016
  • Anne Mari Rokstad, Shamal Hamad, Bjørg Steinkjer, Hilde Fure, Nathalie Niyonzima, Mathias Pontus Ørning m.fl.:
    Initial inflammatory and haemostatic mechanisms induced by endogenous and bioartificial surfaces in a whole blood model
    2014
  • Anne Mari Rokstad, Mathias Pontus Ørning, Shamal Hamad, Kine Samseth Hoem, Bjørg Steinkjer, Hilde Fure m.fl.:
    Inflammatory and hemostatic activation induced by alginate microcapsules reveals novel mechanisms underlying their biocompatibility
    2014
  • Marie Hjelmseth Aune, Eivind Samstad, Nathalie Niyonzima, Stig Haugset Nymo, Liv Ryan, Knut Tore Lappegård m.fl.:
    Cholesterol crystals induce complement-dependent inflammasome activation
    2014
  • Ole Lars Brekke, Anne Landsem, Hilde Fure, Dorte Christiansen, Erik Waage Nielsen, J.D. Lambris m.fl.:
    Key role of tissue factor in complement-mediated coagulation activation by Escherichia coli and LPS
    Molecular Immunology 2013 DOI
  • A Landsem, Hilde Fure, Erik Waage Nielsen, Tom Eirik Mollnes, Ole Lars Brekke :
    Effects of C1-inhibitor on clot development in human whole blood analyzed using rotational thromboelastography
    Molecular Immunology 2013 DOI
  • Stig Haugset Nymo, Eivind Samstad, Nathalie Niyonzima, Marie Hjelmseth Aune, Grete Bergseth, Liv Ryan m.fl.:
    Cholesterol crystals activate the complement system and are phagocytosed in a complement-dependent manner
    Molecular Immunology 2013 DOI
  • Eivind Samstad, Nathalie Niyonzima, Stig Haugset Nymo, Marie Hjelmseth Aune, Liv Ryan, Ole Lars Brekke m.fl.:
    Cholesterol crystals induce inflammasome activation and cytolcine release in a complement-dependent manner
    Molecular Immunology 2013 DOI
  • Anne Mari Rokstad, Ole Lars Brekke, Bjørg Steinkjer, Liv Ryan, Gabriela Kolláriková, John D. Lambris m.fl.:
    Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism
    Immunobiology 2012 DOI
  • Anne Mari Rokstad, Ole Lars Brekke, Bjørg Steinkjer, Liv Ryan, Gabriela Kolláriková, John D. Lambris m.fl.:
    Poly-cation containing alginate microcapsules induce cytokines by a complement-dependent mechanism
    2012 FULLTEKST / DATA

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